TABLE OF CONTENTS I
List of Figures VII
LIST OF CHARTS XV
EXECUTIVE SUMMARY 1
EUROPEAN DENTAL BONE GRAFT SUBSTITUTE AND OTHER BIOMATERIALS MARKET OVERVIEW 1
COMPETITIVE ANALYSIS 3
MARKET TRENDS 5
MARKET DEVELOPMENTS 6
PROCEDURE NUMBERS 7
MARKETS INCLUDED 8
KEY REPORT UPDATES 9
VERSION HISTORY 9
RESEARCH METHODOLOGY 10
Step 1: Project Initiation & Team Selection 10
Step 2: Prepare Data Systems and Perform Secondary Research 13
Step 3: Preparation for Interviews & Questionnaire Design 15
Step 4: Performing Primary Research 16
Step 5: Research Analysis: Establishing Baseline Estimates 18
Step 6: Market Forecast and Analysis 19
Step 7: Identify Strategic Opportunities 21
Step 8: Final Review and Market Release 22
Step 9: Customer Feedback and Market Monitoring 23
DISEASE OVERVIEW 24
2.1 BASIC ANATOMY 24
2.1.1 Dental Anatomy: Oral Cavity and Intraoral landmarks 24
2.2 DISEASE PATHOLOGY AND DISORDERS 26
2.2.1 General Diagnostics 26
2.2.2 Indication for Dental Implant 26
2.2.2.1 Periodontal Disease 27
2.2.2.2 Dental Implant Procedures 27
2.2.2.3 Guided Bone Regeneration 29
2.3 PATIENT DEMOGRAPHICS 30
2.3.1 General Dental Statistics 30
2.3.2 Tooth Loss Statistics 31
PRODUCT ASSESSMENT 33
3.1 INTRODUCTION 33
3.2 PRODUCT PORTFOLIOS 33
3.2.1 Dental Bone Graft Substitutes 33
3.2.1.1 Allografts 34
3.2.1.1.1 Mineralized Allografts 34
3.2.1.1.2 Demineralized Bone Matrix 35
3.2.1.2 Autografts 35
3.2.1.3 Synthetics 36
3.2.1.4 Xenografts 37
3.2.2 Dental Growth Factor 41
3.2.3 Dental Barrier Membranes 42
3.3 REGULATORY ISSUES AND RECALLS 45
3.3.1 Dental Bone Graft Substitutes 45
3.3.2 Dental Growth Factor 47
3.3.3 Dental Barrier Membranes 48
3.4 CLINICAL TRIALS 49
3.4.1 Dental Bone Graft Substitutes 49
3.4.2 Dental Growth Factor 55
3.4.3 Dental Barrier Membranes 57
EUROPEAN DENTAL BONE GRAFT SUBSTITUTE AND OTHER BIOMATERIALS MARKET OVERVIEW 60
4.1 CURRENCY EXCHANGE RATE 60
4.2 MARKET OVERVIEW 61
4.3 TREND ANALYSIS BY SEGMENT 67
4.4 DRIVERS AND LIMITERS 70
4.4.1 Market Drivers 70
4.4.2 Market Limiters 72
4.5 COMPETITIVE MARKET SHARE ANALYSIS 75
4.6 MERGERS AND ACQUISITIONS 84
4.7 COMPANY PROFILES 86
4.7.1 ACE Surgical Supply Co., Inc. 86
4.7.2 Baumer S.A. 87
4.7.3 BioHorizons 88
4.7.4 Biotech Dental Group 89
4.7.5 Botiss Biomaterials 90
4.7.6 B&W Sistema de Implantes 91
4.7.7 Dentsply Sirona 92
4.7.8 Geistlich Biomaterials 94
4.7.9 Implant Direct 95
4.7.10 LifeNet Health 96
4.7.11 Nobel Biocare 97
4.7.12 Osteogenics Biomedical 98
4.7.13 Straumann Group 99
4.7.14 Zimmer Biomet 101
4.8 SWOT ANALYSIS 103
4.8.1 ACE Surgical Supply Co., Inc. 103
4.8.2 Baumer S.A. 104
4.8.3 BioHorizons 105
4.8.4 Biotek Dental Group 106
4.8.5 Botiss Biomaterials 107
4.8.6 B&W Sistema de Implantes 108
4.8.7 Dentsply Sirona 109
4.8.8 Geistlich Biomaterials 110
4.8.9 Implant Direct 111
4.8.10 LifeNet Health 112
4.8.11 Nobel Biocare 113
4.8.12 Osteogenics Biomedical 114
4.8.13 Straumann Group 115
4.8.14 Zimmer Biomet 116
COUNTRY PROFILES 117
5.1 INTRODUCTION 117
5.1.1 Population 117
5.1.2 GDP Per Capita 117
5.1.3 Price Index 117
5.2 GERMANY 118
5.3 FRANCE 119
5.4 UNITED KINGDOM 120
5.5 ITALY 121
5.6 SPAIN 122
5.7 BENELUX 123
5.8 SCANDINAVIA 124
5.9 AUSTRIA 125
5.10 SWITZERLAND 126
5.11 PORTUGAL 127
PROCEDURE NUMBERS 128
6.1 INTRODUCTION 128
6.2 DENTAL BONE GRAFTING PROCEDURE NUMBERS 129
6.2.1 Dental Bone Graft Substitute Penetration Rate 129
DENTAL BONE GRAFT SUBSTITUTE MARKET 133
7.1 INTRODUCTION 133
7.1.1 Autografts 133
7.1.2 Allografts 134
7.1.2.1 Mineralized Allografts 134
7.1.2.2 Demineralized Bone Matrix Allografts 135
7.1.3 Xenografts 135
7.1.4 Synthetics 136
7.2 MARKET OVERVIEW 137
7.3 MARKET ANALYSIS AND FORECAST 143
7.3.1 Total Dental Bone Graft Substitute Market 143
7.3.2 Total Allograft Market 151
7.3.2.1 Mineralized Allograft Market 162
7.3.2.2 Demineralized Bone Matrix Allograft Market 169
7.3.3 Xenograft Market 177
7.3.4 Synthetic Market 185
7.4 DRIVERS AND LIMITERS 193
7.4.1 Market Drivers 193
7.4.2 Market Limiters 195
7.5 COMPETITIVE MARKET SHARE ANALYSIS 198
DENTAL GROWTH FACTOR MARKET 211
8.1 INTRODUCTION 211
8.2 MARKET ANALYSIS AND FORECAST 213
8.2.1 Emdogain? Market 213
8.3 DRIVERS AND LIMITERS 221
8.3.1 Market Drivers 221
8.3.2 Market Limiters 222
DENTAL BARRIER MEMBRANE MARKET 224
9.1 INTRODUCTION 224
9.2 MARKET OVERVIEW 227
9.3 MARKET ANALYSIS AND FORECAST 232
9.3.1 Total Dental Barrier Membrane Market 232
9.3.2 Resorbable Dental Barrier Membrane Market 240
9.3.3 Non-Resorbable Dental Barrier Membrane Market 247
9.4 DRIVERS AND LIMITERS 254
9.4.1 Market Drivers 254
9.4.2 Market Limiters 255
9.5 COMPETITIVE MARKET SHARE ANALYSIS 257
APPENDIX: EASTERN EUROPEAN DENTAL BONE GRAFT SUBSTITUTE MARKET 263
10.1 MARKET OVERVIEW 263
10.2 MARKET ANALYSIS AND FORECAST 268
10.2.1 Total Dental Bone Graft Substitute Market 268
10.2.2 Total Allograft Market 275
10.2.2.1 Mineralized Allograft Market 285
10.2.2.2 Demineralized Bone Matrix Allograft Market 292
10.2.3 Xenograft Market 299
10.2.4 Synthetic Market 306
ABBREVIATIONS 313