Market Overview

The Global Knee Replacement Market reached US$ 10.85 Billion in 2024 and is expected to reach US$ 16.72 Billion by 2033, growing at a CAGR of 4.8% during the forecast period 2025-2033.

Knee Replacement Devices are medical implants designed to replace damaged or diseased parts of the knee joint, often due to conditions like osteoarthritis or rheumatoid arthritis. They aim to restore mobility, reduce pain, and improve knee joint function, and are commonly used in surgical procedures like total or partial knee replacements. 

Market Dynamics: Drivers & Restraints

Growing Prevalence of Osteoarthritis

The global knee replacement market is driven by the increasing prevalence of osteoarthritis, a degenerative joint disease affecting knee function, especially in the elderly population. As the global population ages, joint-related issues like chronic knee pain and reduced mobility increase, leading to a higher demand for knee replacement procedures. Increased awareness, surgical advancements, and improved implant materials have further accelerated the adoption of these devices globally.

For instance, Osteoarthritis (OA) is the most common form of arthritis, affecting around 500 million people globally, or 7% of the population. In the US, over 32 million people have OA. The condition is more common among older adults and females, with other risk factors including injury, obesity, and genetics. This article discusses the prevalence of OA in the US and worldwide, its effects, causes, effects, and prevention methods. It also explores ways to help prevent the condition.

High Cost of Knee Replacement Procedures

The high cost of knee replacement surgeries, including implant devices, hospital charges, surgical fees, rehabilitation, and post-operative care, is a significant restraint in the market. This is particularly challenging in regions with limited healthcare infrastructure or inadequate insurance coverage. In developing countries, the lack of affordable healthcare options and access to advanced surgical facilities further restricts the adoption of knee replacement devices.

Market Segment Analysis

The global Knee Replacement market is segmented based on Procedure Type, Implant Type, Component, Fixation Type, End User and Region.

Procedure Type:

Total Knee Replacement segment is expected to dominate the Knee Replacement market share

The Total Knee Replacement segment holds a major portion of the knee replacement market share and is expected to continue to hold a significant portion of the knee replacement market share during the forecast period. 

Total Knee Replacement (TKR) is a surgical procedure that replaces a damaged or diseased knee joint with an artificial prosthesis, often recommended for severe knee pain from conditions like osteoarthritis, rheumatoid arthritis, or traumatic injuries. The procedure involves replacing the femoral, tibial, and patellar components of the knee with metal, plastic, or ceramic implants. The goal is to alleviate pain, improve mobility, and restore knee joint functionality, allowing patients to return to daily activities and improve their quality of life.

For instance, in June 2024, Meril, an India-based medical device company, has launched its indigenously developed advanced surgical robotic technology, MISSO, which will assist doctors in real-time knee replacement procedures. This technology will reduce the investment required for knee replacement surgeries by 66%, making them more accessible and affordable. Meril plans to adapt this technology for other joint surgeries in the future.

End User:-

Hospitals segment is the fastest-growing segment in Knee Replacement market  share

The hospitals segment is the fastest-growing segment in the Knee Replacement market share and is expected to hold the market share over the forecast period.

Hospitals are vital in the Total Knee Replacement (TKR) procedure due to their infrastructure, specialized medical staff, and postoperative care. They use advanced diagnostic tools to assess knee damage severity and perform the procedure using advanced surgical techniques and implant technologies. Post-surgery, hospitals offer comprehensive rehabilitation programs to help patients regain strength, flexibility, and function. They also monitor patients for potential complications and provide pain management options. A multidisciplinary care approach is essential for achieving optimal results in TKR surgeries.

For instance, in November 2024, Lower Bucks Hospital has introduced Persona IQ, the first smart knee implant to receive De Novo classification from the U.S. Food and Drug Administration for total knee replacement procedures. This innovative implant integrates the Persona Personalized Knee with advanced implantable sensor technology, measuring range of motion, step count, walking speed, and other vital gait metrics. 

Moreover, in January 2024, Omega Hospitals, Gachibowli, has successfully performed a knee replacement surgery on a 60-year-old woman using 3D augmented realty glasses, a proprietary technology from France. The technology, which uses computer navigation solutions, helped achieve accurate limb alignment, reduced blood loss, smaller incisions, and facilitated early recovery, according to Dr Aditya Kapoor, Director of Orthopaedics at the hospital.

Market Geographical Share

North America is expected to hold a significant position in the Knee Replacement market  share

North America holds a substantial position in the Knee Replacement market and is expected to hold most of the market share due to high prevalence of osteoarthritis and degenerative joint diseases, as well as the aging population and rising obesity rates. The region's advanced healthcare infrastructure, well-established reimbursement policies, and access to advanced surgical technologies like robotic-assisted knee replacement systems support market growth. The strong focus on research and development, key market players, and high patient awareness accelerate the adoption of knee replacement implants in North America.

For instance, according to Bone and Joint Canada, currently in Canada, there are more than 4.6 million OA patients, which in another generation (30 years from now) would rise to more than 10 million-or one in four. 

Moreover, in November 2024, Zimmer Biomet Holdings has received FDA Premarket Approval Application Supplement approval for the Oxford Cementless Partial Knee. The approval is based on safety and effectiveness data from an Investigational Device Exemption study and non-clinical testing for cementless partial knee replacement (PKR). The Oxford Cementless Partial Knee offers improved fixation, long-term implant survival rate, and operating room efficiency compared to the Oxford Cemented Partial Knee procedure. 

Europe is growing at the fastest pace in the Knee Replacement market  

Europe holds the fastest pace in the Knee Replacement market and is expected to hold most of the market share due to increasing aging populations, osteoarthritis, and increased awareness about joint health. With robust healthcare systems and technological advancements, knee replacement surgeries are more accessible to a larger population. Government initiatives, leading orthopedic companies, and strong regulatory support through CE certifications further drive the market's growth. Technological advancements, minimally invasive surgical techniques, and post-operative rehabilitation programs also contribute to improved patient outcomes.

For instance, in June 2024, Corin, a leading robotics and AI innovator in orthopaedics, has launched its ApolloKnee surgical application and Apollo platform for robotic-assisted total knee arthroplasty. The applications have received regulatory clearance in all major markets and have been used to objectively balance knees in over 200 patients. Corin's CEO, Jon Serbousek, praised the success of the early release as a testament to their cross-functional teams and scalable manufacturing capabilities.

Major Global Players

The major global players in the Knee Replacement market include Zimmer Biomet Holdings, Inc, Stryker Corporation, DePuy Synthes (Johnson & Johnson), Smith & Nephew Plc, B. Braun Melsungen AG, Medtronic Plc, MicroPort Scientific Corporation, Exactech, Inc, Conformis, Inc, DJO Global, Inc and among others.

Key Developments

  • In February 2025, Meril, an India-based medical device company, has launched its indigenously developed advanced surgical robotic technology, MISSO, which will assist doctors during knee replacement procedures in real-time. MISSO will reduce the investment required for knee replacement surgeries by 66%, making them more accessible and affordable. The technology can be adapted for other joint surgeries in the future.
  • In October 2024, Exactech has received FDA clearance for its Truliant Porous Tibial Tray, a 3D tibial knee implant. The device uses additive manufacturing to create a porous structure mimicking cancellous bone, facilitating both initial and biological fixation, and accommodating patients' active lifestyles. 

Why Purchase the Report?

  • Pipeline & Innovations: Reviews ongoing clinical trials, product pipelines, and forecasts upcoming advancements in medical devices and pharmaceuticals.
  • Product Performance & Market Positioning: Analyzes product performance, market positioning, and growth potential to optimize strategies.
  • Real-World Evidence: Integrates patient feedback and data into product development for improved outcomes.
  • Physician Preferences & Health System Impact: Examines healthcare provider behaviors and the impact of health system mergers on adoption strategies.
  • Market Updates & Industry Changes: Covers recent regulatory changes, new policies, and emerging technologies.
  • Competitive Strategies: Analyzes competitor strategies, market share, and emerging players.
  • Pricing & Market Access: Reviews pricing models, reimbursement trends, and market access strategies.
  • Market Entry & Expansion: Identifies optimal strategies for entering new markets and partnerships.
  • Regional Growth & Investment: Highlights high-growth regions and investment opportunities.
  • Supply Chain Optimization: Assesses supply chain risks and distribution strategies for efficient product delivery.
  • Sustainability & Regulatory Impact: Focuses on eco-friendly practices and evolving regulations in healthcare.
  • Post-market Surveillance: Uses post-market data to enhance product safety and access.
  • Pharmacoeconomics & Value-Based Pricing: Analyzes the shift to value-based pricing and data-driven decision-making in R&D.

 

The global Knee Replacement market report delivers a detailed analysis with 61 key tables, more than 59 visually impactful figures, and 220 pages of expert insights, providing a complete view of the market landscape.

 

Target Audience 2025

  • Manufacturers: Pharmaceutical, Medical Device, Biotech Companies, Contract Manufacturers, Distributors, Hospitals.
  • Regulatory & Policy: Compliance Officers, Government, Health Economists, Market Access Specialists.
  • Procedure Type & Innovation: AI/Robotics Providers, R&D Professionals, Clinical Trial Managers, Pharmacovigilance Experts.
  • Investors: Healthcare Investors, Venture Fund Investors, Pharma Marketing & Sales.
  • Consulting & Advisory: Healthcare Consultants, Industry Associations, Analysts.
  • Supply Chain: Distribution and Supply Chain Managers.
  • Consumers & Advocacy: Patients, Advocacy Groups, Insurance Companies.
  • Academic & Research: Academic Institutions.