[196 Pages Report] The Peptide Therapeutics Market size was estimated at USD 33.06 billion in 2023 and expected to reach USD 35.76 billion in 2024, at a CAGR 8.35% to reach USD 57.97 billion by 2030.
Peptide therapeutics use short chains of amino acids to treat or control various diseases and medical conditions. These biologically active molecules possess unique properties, making them an efficient drug development and pharmaceutical research option. The surging prevalence of chronic diseases, including cancer and diabetes, is raising the need for effective treatment options and an improved understanding of protein-protein interactions leading to targeted therapies. The growing investment in research & development activities and a robust clinical pipeline with therapeutic candidates result in novel peptide therapeutics being developed. However, the inherent instability of peptides and the high cost of manufacturing peptides may adversely impact the development of peptide therapeutics. Moreover, recent developments in drug delivery systems and the development of new peptides are expected to expand the potential applications for peptides.
Technology: Rising utilization of solid phase approach for synthesis of complex peptides
The hybrid phase approach combines liquid-phase and solid-phase synthesis features to enhance efficiency and scalability while maintaining high purity levels for peptide production. This technique is favored while developing complex or large peptides due to its ability to overcome challenges associated with traditional methods. Liquid phase peptide synthesis (LPPS) involves coupling amino acids in solution using various chemical reactions. LPPS is suitable for small-scale production of short to medium-length peptides due to its relatively fast reaction rates compared to solid-phase methods. Solid phase peptide synthesis (SPPS) involves attaching the first amino acid to a solid resin support, followed by the sequential addition of subsequent amino acids. This method is widely preferred due to its ability to synthesize longer and more complex peptides and ease of purification and scalability. Hybrid phase technology is preferred for developing large or complex peptides due to its combined advantages from liquid and solid phases. Liquid phase synthesis is primarily used for small-scale, short- to medium-length peptide production. Solid-phase peptide synthesis is widely favored due to its versatility in synthesizing longer and more complex peptides while offering easy purification and scalability options.
Drug Class: Increasing need for insulin to regulate glucose metabolism for type 1 and type 2 diabetes
Adrenocorticotropic hormone (ACTH) is a polypeptide hormone secreted and produced by the anterior pituitary gland. Therapeutically, ACTH is utilized in managing certain disorders where there is a need to stimulate cortisol production. This includes treatment for conditions such as adrenal insufficiency and certain inflammatory disorders that respond to increased cortisol levels. The exogenous form used in therapy provides a direct stimulus to the adrenal cortex by simulating the action of occurring ACTH, encouraging it to secrete cortisol, thereby exerting anti-inflammatory and immunostimulatory effects. Calcitonin is critical in calcium and phosphorus metabolism. It is produced in humans primarily by the parafollicular thyroid gland cells. Therapeutic forms of calcitonin, derived from salmon or synthetically produced, are utilized primarily in treating postmenopausal osteoporosis, Paget’s disease, and hypercalcemia. By inhibiting osteoclast activity, calcitonin reduces bone resorption, thereby decreasing blood calcium levels. Insulin is a fundamental peptide hormone critical for regulating glucose metabolism produced by the beta cells of the pancreas, facilitating glucose uptake from the blood into the muscle, liver, and fat cells. In the therapeutic context, insulin is vital in managing diabetes mellitus, both type 1 and type 2, where the body’s ability to produce or respond to insulin is impaired. Leuprorelin is a synthetic analog of gonadotropin-releasing hormone (GnRH) and functions as a potent inhibitor of gonadotropin secretion when used in continuous administration. It is employed in the treatment of hormone-responsive cancers such as prostate cancer in men and endometriosis and uterine fibroids in women. Octreotide is a synthetic octapeptide analog of the natural hormone somatostatin, possessing similar but longer-lasting pharmacological effects. It is primarily used in the management of acromegaly, a condition characterized by excess production of growth hormone, and in the control of symptoms caused by certain types of tumors that secrete hormones, such as carcinoid tumors and vasoactive intestinal peptide-secreting adenomas (VIPomas). Octreotide works by inhibiting the secretion of various hormones, including growth hormone, gastrin, insulin, and glucagon. Vasopressin, also referred to as antidiuretic hormone (ADH), is a peptide hormone that is secreted by the posterior pituitary gland and produced by the hypothalamus. ADH is critical in regulating the body’s water retention by increasing water reabsorption in the kidney’s collecting ducts. In a therapeutic setting, vasopressin and its analogs are used to treat diabetes insipidus, a condition characterized by excess thirst and the production of large amounts of diluted urine, and for managing variceal bleeding due to its vasoconstrictive properties.
Route of Administration: Rising adoption of intravenous administration due to peptide therapeutics immediacy and effectiveness in acute hospital care settings
Intravenous (IV) administration of peptide therapeutics ensures direct delivery into the bloodstream, facilitating immediate bioavailability. This route is particularly advantageous for peptides that are poorly absorbed through the gastrointestinal tract or extensively metabolized when administered by other routes. IV administration is critical for peptides used in acute care settings or where rapid onset of action is necessary. However, it requires clinical infrastructure and skilled personnel to administer, potentially limiting its applicability to outpatient settings or chronic treatments. Nasal & pulmonary routes offer non-invasive administration alternatives for peptide therapeutics, capable of providing efficient absorption and immediate action for certain conditions. Nasal administration is particularly suited for peptides targeting the central nervous system, leveraging the nose-to-brain pathway. Pulmonary administration is ideal for peptides intended for respiratory ailments, allowing direct delivery to the lungs. Both methods bypass first-pass metabolism, potentially increasing the therapeutic’s bioavailability. Oral administration is a preferred route for drug delivery, attributed to its convenience, patient compliance, and cost-effectiveness. Peptides are subject to enzymatic degradation within the gastrointestinal tract and suffer from poor permeability across the intestinal epithelium. Advances in pharmaceutical sciences, such as enzyme inhibitors, permeation enhancers, and nanoparticle delivery systems, have shown promise in overcoming these hurdles, albeit with varying degrees of success. Transdermal delivery of peptide therapeutics offers a compelling balance between efficacy and patient compliance, eliminating the need for injections or specialized inhalation devices. This route is particularly advantageous for chronic conditions requiring sustained release of medication. Advances in transdermal technologies, including microneedles, iontophoresis, and ultrasound, have improved the transport of peptides across the skin barrier. Formulation strategies that enhance skin permeability and peptide stability are central to the successful development of transdermal peptide therapeutics.
Application: Widening use of peptide therapeutics in cardiovascular disorders to simulate the action of endogenous peptides involved in blood pressure regulation
In cardiovascular disorders, peptide therapeutics have been used for their precise mechanisms of action, which can effectively modulate vascular function, blood pressure, and coagulation pathways. Anticoagulant peptides are utilized to prevent thrombosis, a critical risk factor for myocardial infarction and stroke. In gastrointestinal (GI) disorders, peptide therapeutics present an avenue for targeted treatment options. In addition, peptides that mimic or inhibit gastrointestinal hormones can regulate motility, absorption, and secretion within the GI tract, addressing symptoms of various disorders. Their targeted action can aid in managing conditions stemming from hormonal imbalances or disruptions in GI-related disorders. Peptide therapeutics bring a novel approach to managing infectious disorders, especially in an era of increasing antibiotic resistance. Antimicrobial peptides (AMPs) offer a broad-spectrum antimicrobial activity, targeting bacteria, fungi, and even some viruses by disrupting their cellular membranes. Their mode of action reduces the likelihood of resistance development, making them crucial contenders in the fight against drug-resistant infections. In neurological disorders, peptide therapeutics are being explored for their potential for crossing the blood-brain barrier (BBB) and delivering neuroprotective effects directly to the central nervous system (CNS). Peptides target specific neurotransmitter systems, providing opportunities for the treatment of diseases, including Alzheimer’s, Parkinson’s, and multiple sclerosis. In oncology, peptide therapeutics represent a fast-growing area, with peptides being investigated for their anti-cancer properties, including direct cytotoxic effects on cancer cells, inhibition of angiogenesis, and vehicles for targeted drug delivery. Tumor-homing peptides are able to selectively deliver chemotherapeutic agents or radionuclides to tumor cells, minimizing damage to healthy tissues and enhancing treatment efficacy.
End User: Expanding the use of peptide therapeutics in hospitals and clinics to address and manage patient conditions
In hospitals & clinics, peptide therapeutics are primarily utilized for direct patient care. They are employed in treating numerous conditions, including cancer, metabolic disorders, cardiovascular diseases, and infectious diseases. Peptide drugs offer a targeted approach to treatment due to their high specificity and potency with relatively low toxicity, allowing for higher efficacy with potentially fewer side effects compared to traditional small molecule drugs. Their application in hospitals & clinics continuously evolves with advances in peptide engineering and drug delivery technologies, enhancing their effectiveness and patient compliance. Long-term care facilities prioritize treatments that ensure the well-being of patients over extended periods, often focusing on management rather than cure. Peptide therapeutics used in long-term care facilities need to have minimal side effects and require less frequent dosing schedules to accommodate the caregiving environment. Research laboratories are crucial in the early stages of peptide therapeutic development. Researchers focus on identifying new bioactive peptides, elucidating their mechanisms of action, and optimizing their properties for therapeutic use. This involves cutting-edge molecular biology, biochemistry, and pharmacology techniques to design, synthesize, and assess the activity of peptide candidates.
Manufacturing Type: Increasing adoption of CMOs owing to the need for specialized manufacturing capabilities and the ability to scale production rapidly
Contract manufacturing organizations provide essential services in the production of peptide therapeutics, serving pharmaceutical and biotech companies that either do not possess the necessary in-house production facilities or choose to outsource manufacturing to focus on core competencies. CMOs offer various services, from synthesizing peptides in small quantities for research purposes to large-scale production for commercial use. They possess the technical expertise, advanced technologies, and regulatory knowledge required for the efficient and compliant manufacture of peptide therapeutics. In-house production refers to the scenario where pharmaceutical or biotechnology companies have the facilities and resources to manufacture peptide therapeutics. This approach allows companies to maintain direct control over the production processes, quality control, and supply chain management, potentially reducing risks associated with reliance on external suppliers. Large pharmaceutical companies often establish in-house production facilities with the financial resources to invest in the necessary infrastructure and skilled personnel. This model facilitates closer integration between research and development activities and manufacturing, which can be advantageous in rapidly evolving therapeutic areas.
Regional Insights
The peptide therapeutics market is evolving in the Americas due to well-established pharmaceutical industries, increased research activities, and a growing number of approved peptide drugs. Patent activity in this region is notable, with several major pharmaceutical companies headquartered in the area. In recent years, investments in innovative peptide formulations have increased, indicating a robust market potential for new therapeutic approaches. The rising prevalence of chronic disease, improving healthcare infrastructure, and growing awareness regarding peptide therapeutics are encouraging the growth of the peptide therapeutics market in the APAC region. In addition, ongoing advancements and the development of efficient, scalable, and cost-effective synthetic strategies for producing peptides are anticipated to encourage the adoption of peptide therapeutics globally. The peptide therapeutics market is developing in the EMEA region owing to the regulatory framework supporting innovation within biotechnology and funding research projects related to peptide therapeutics. The European Union demonstrates a well-established market for peptide therapeutics, supported by comprehensive healthcare systems and a high degree of awareness regarding advanced treatment options. The EU’s regulatory framework, through the European Medicines Agency (EMA), has been instrumental in approving and monitoring peptide-based drugs. The peptide therapeutics market in the African region is currently growing steadily, characterized by growing research activities and increasing awareness toward advanced therapeutic options.
FPNV Positioning Matrix
The FPNV Positioning Matrix is pivotal in evaluating the Peptide Therapeutics Market. It offers a comprehensive assessment of vendors, examining key metrics related to Business Strategy and Product Satisfaction. This in-depth analysis empowers users to make well-informed decisions aligned with their requirements. Based on the evaluation, the vendors are then categorized into four distinct quadrants representing varying levels of success: Forefront (F), Pathfinder (P), Niche (N), or Vital (V).
Market Share Analysis
The Market Share Analysis is a comprehensive tool that provides an insightful and in-depth examination of the current state of vendors in the Peptide Therapeutics Market. By meticulously comparing and analyzing vendor contributions in terms of overall revenue, customer base, and other key metrics, we can offer companies a greater understanding of their performance and the challenges they face when competing for market share. Additionally, this analysis provides valuable insights into the competitive nature of the sector, including factors such as accumulation, fragmentation dominance, and amalgamation traits observed over the base year period studied. With this expanded level of detail, vendors can make more informed decisions and devise effective strategies to gain a competitive edge in the market.
Key Company Profiles
The report delves into recent significant developments in the Peptide Therapeutics Market, highlighting leading vendors and their innovative profiles. These include AbbVie Inc., AmbioPharm, Inc., Amgen Inc., Amide Technologies, Inc., AstraZeneca PLC, Bachem Holding AG, Biosynth Ltd., Bristol Myers Squibb Company, Cidara Therapeutics, Inc., Corden Pharma International GmbH, Cybrexa, Inc., Eccogene, Eli Lilly and Company, Exelixis, Inc., F. Hoffmann-La Roche Ltd., GlaxoSmithKline PLC, Ipsen Group, IRBM S.p.A., Ironwood Pharmaceuticals, Inc., Merck KGaA, Novartis AG, Novo Nordisk A/S, Otsuka Pharmaceutical Co., Ltd., Peptidream Co., Ltd., Perpetual Medicines Corporation, Pfizer Inc., Piramal Pharma Limited, PolyPeptide Group AG, RELIEF THERAPEUTICS Holding SA, Sanofi S.A., Sanyou Biopharmaceuticals Co., Ltd., Shanghai Full-Life Technologies Co, Ltd., Takeda Pharmaceutical Company Limited, Teva Pharmaceutical Industries Limited, WuXi AppTec Co., Ltd., and Zealand Pharma A/S.
Market Segmentation & Coverage
This research report categorizes the Peptide Therapeutics Market to forecast the revenues and analyze trends in each of the following sub-markets:
- Technology
- Hybrid Phase
- Liquid Phase
- Solid Phase
- Drug Class
- Adrenocorticotropic Hormone
- Calcitonin
- Insulin
- Leuprorelin
- Octreotide
- Vasopressin
- Route of Administration
- Intravenous Administration
- Nasal & Pulmonary Administration
- Oral Administration
- Transdermal Administration
- Application
- Cardiovascular Disorders
- Gastrointestinal Disorders
- Infectious Disorders
- Neurological Disorders
- Oncology
- End User
- Hospitals & Clinics
- Long-term Care Facilities
- Research Laboratories
- Manufacturing Type
- Contract Manufacturing Organization
- In-house
- Region
- Americas
- Argentina
- Brazil
- Canada
- Mexico
- United States
- California
- Florida
- Illinois
- Indiana
- Maryland
- Massachusetts
- Minnesota
- New Jersey
- New York
- North Carolina
- Ohio
- Pennsylvania
- Texas
- Asia-Pacific
- Australia
- China
- India
- Indonesia
- Japan
- Malaysia
- Philippines
- Singapore
- South Korea
- Taiwan
- Thailand
- Vietnam
- Europe, Middle East & Africa
- Denmark
- Egypt
- Finland
- France
- Germany
- Israel
- Italy
- Netherlands
- Nigeria
- Norway
- Poland
- Qatar
- Russia
- Saudi Arabia
- South Africa
- Spain
- Sweden
- Switzerland
- Turkey
- United Arab Emirates
- United Kingdom
- Americas
The report offers valuable insights on the following aspects:
- Market Penetration: It presents comprehensive information on the market provided by key players.
- Market Development: It delves deep into lucrative emerging markets and analyzes the penetration across mature market segments.
- Market Diversification: It provides detailed information on new product launches, untapped geographic regions, recent developments, and investments.
- Competitive Assessment & Intelligence: It conducts an exhaustive assessment of market shares, strategies, products, certifications, regulatory approvals, patent landscape, and manufacturing capabilities of the leading players.
- Product Development & Innovation: It offers intelligent insights on future technologies, R&D activities, and breakthrough product developments.
The report addresses key questions such as:
- What is the market size and forecast of the Peptide Therapeutics Market?
- Which products, segments, applications, and areas should one consider investing in over the forecast period in the Peptide Therapeutics Market?
- What are the technology trends and regulatory frameworks in the Peptide Therapeutics Market?
- What is the market share of the leading vendors in the Peptide Therapeutics Market?
- Which modes and strategic moves are suitable for entering the Peptide Therapeutics Market?
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