The Global Lymphoma Therapeutics Market size is expected to reach $24.9 billion by 2029, rising at a market growth of 7.8% CAGR during the forecast period.
The term "lymphoma therapeutics" refers to the numerous medical treatments and interventions that are intended to treat lymphoma, a form of cancer that impacts the lymphatic system, which is a component of the immune system of the body. Lymphoma is one of the most common types of cancer globally. The elimination of malignant cells, the prevention of the disease’s progression, and an improvement in the patient’s standard of life are the primary focuses of lymphoma treatment strategies.
The spleen, the thymus gland, lymph nodes (also known as lymph glands), and bone marrow are all elements that make up the lymphatic system. Lymphoma has the potential to affect not only these areas, but many other organs located throughout the body as well. Lymphoma patients have access to various treatment options, including radiation therapy, chemotherapy, immunotherapy, targeted therapy, and stem cell transplantation, among others.
The choice of treatment is determined not only by the type and stage of lymphoma but also by additional criteria, such as the patient’s current state of health and medical history. Lymphoma treatments work toward the dual goals of inducing individuals with lymphoma into a state of long-term remission while also improving their chances of survival.
Cancer of the lymphatic system is referred to as lymphoma, and lymphoma is a subtype of cancer characterized by the fast proliferation of aberrant malignant cells. It typically affects the white blood cells (WBCs), also known as lymphocytes, in the lymph nodes, spleen, thymus, and bone marrow. This has the effect of reducing the body’s ability to mount an immune response. As a result, the patient experiences symptoms such as swelling in the lymph nodes, high fever, loss of weight, shortness of breath, and weariness as a direct effect of the condition.
COVID-19 Impact Analysis
The pandemic negatively impacted the lymphoma therapeutics market due to delayed diagnosis and treatment and disruptions to clinical trials. Lymphoma therapeutics pose a challenge for healthcare professionals due to the potential risk of chemotherapeutic and immunosuppressive treatment exacerbating comorbid COVID-19 infections, which are crucial aspect of cancer therapy. Patients with B-cell non-Hodgkin’s lymphoma (B-NHL), who have recently undergone treatment with anti-CD20 antibodies, are susceptible to severe COVID-19 disease.
Market Growth Factors
Technological advancement in the treatment options
Various treatment developments have been introduced in lymphoma therapeutics by focusing on TAAs; cancer immunotherapy has become a crucial part of cancer treatment. It does not produce unintended off-target effects and has several clinical advantages. This encourages the creation of highly effective, low-side-effect tailored recombinant vaccines for cancer immunotherapy. Immune checkpoint inhibitors (ICIs), recently developed, have changed cancer treatment and increased patient survival. ICIs tailored to checkpoint proteins, like CTLA-4 or PD-1, have been approved to treat several cancer types. These factors are propelling market growth.
Increasing cases of Lymphoma, raising the demand for therapeutics
Around half a million new cases of NHL were reported globally in 2018, accounting for 2.8% of all cancer diagnoses. The gender-specific age-standardized probability of developing NHL was found to be 6.7 in men and 4.7 in women. This indicates that men have a cumulative lifetime risk of 0.72%, while women have a risk of 0.35%. Furthermore, men’s incidence was 7.8/100,000, and women’s was 5.6/100,000 and 2.9/100,000 in high and low/medium human development index nations, respectively. Hence, the growing cases of Lymphoma, especially non-Hodgins Lymphoma (NHL), are expected to increase the demand for numerous lymphoma therapeutics boosting the market growth in the projected period.
Market Restraining Factors
The associated side effects of treatments
The treatment for lymphoma is associated with side effects. Some of them are digestive issues, "Chemo brain," itchy, painful, and dry skin, fatigue, nausea, and vomiting, hair loss, sleep issues, peripheral neuropathy (nerve injury), and oral mucositis (sore mouth). The risk of infection may rise after the treatment of lymphoma. Therefore, it’s crucial to be aware of the warning signs and symptoms and how to get in touch with the medical team if necessary. Lack of specific blood cell types can result from cancer treatment. Low red blood cells, low white blood cells, and low platelets are all symptoms of anemia. These are expected to hinder the lymphoma therapeutics market growth in the projected period.
Disease Type Outlook
Based on disease Type, the lymphoma therapeutics market is segmented into Hodgkin lymphoma and non-Hodgkin lymphoma. The Hodgkin lymphoma segment acquired a significant revenue share in the lymphoma therapeutics market in 2022. The growth is attributed due to the reasons such as the rising prevalence of Hodgkin lymphoma, increased awareness of the disease, and the significant unmet needs of elderly patients and patients with relapsed or refractory (R/R) HL. The moderately aggressive cancer Hodgkin lymphoma can quickly spread throughout the body. Despite this, it’s also one of the cancer forms that is most easily cured.
Treatment Type Outlook
On the basis of treatment Type, the lymphoma therapeutics market is divided into immune therapy, chemotherapy, target therapy and radiation therapy. The immune therapy segment held the highest revenue share in the lymphoma therapeutics market in 2022. The growth of immune therapy can be attributed to the progress in immunology, the wider accessibility of immune therapies, and the increasing number of product approvals globally. Immunotherapy has been found to be a highly successful treatment option with positive outcomes.
Route of Administration Outlook
By route of administration, the lymphoma therapeutics market is classified into oral route and injectable. The injectable segment witnessed the largest revenue share in the lymphoma therapeutics market in 2022. This is because the injection is administered subcutaneously and has a duration of 5-7 minutes. This method is significantly faster than intravenous administration. These products have been approved for usage in patients diagnosed with diffuse large B-cell lymphoma, follicular lymphoma, and chronic lymphocytic leukemia.
Distribution Channel Outlook
Based on the distribution channel, the lymphoma therapeutics market is bifurcated into hospital pharmacies, retail pharmacies and others. The retail pharmacies segment recorded a significant revenue share in the lymphoma therapeutics market in 2022. This is because retail pharmacies are responsible for the preparation and distribution of medications, as well as the counseling of customers regarding the proper use of medications and the provision of information regarding probable drug interactions. Also, customers can get advice from retail pharmacists regarding general health concerns as well as over-the-counter medications.
Regional Outlook
Region-wise, the lymphoma therapeutics market is analyzed across North America, Europe, Asia Pacific, and LAMEA. The North America region led the lymphoma therapeutics market by generating the maximum revenue share in 2022. This is due to an increase in lymphoma prevalence, advancements in lymphoma therapeutics, including targeted therapies and immunotherapies, and an increase in the number of new product releases by significant market players in this region. Additionally, the existence of important players, the accessibility of cutting-edge medications, the well-established healthcare system, and substantial R&D spending will surge the market growth in the region.
The major strategies followed by the market participants are Acquisitions. Based on the Analysis presented in the Cardinal matrix; Pfizer, Inc., Johnson & Johnson, and F. Hoffmann-La Roche Ltd. are the forerunners in the Lymphoma Therapeutics Market. Companies such as Eli Lilly And Company, Gilead Sciences, Inc., and Bristol Myers Squibb Company are some of the key innovators in Lymphoma Therapeutics Market.
The market research report covers the analysis of key stake holders of the market. Key companies profiled in the report include AstraZeneca PLC, Bayer AG, Bristol Myers Squibb Company, F. Hoffmann-La Roche Ltd., Johnson & Johnson, Gilead Sciences, Inc., Seagen, Inc., Teva Pharmaceutical Industries Ltd., Pfizer, Inc. and Eli Lilly And Company.
Recent Strategies Deployed in Lymphoma Therapeutics Market
Partnerships, Collaborations and Agreements:
Jun-2022: AstraZeneca came into collaboration with GRAIL, LLC, a healthcare company whose focus is to detect cancer early when it can be cured. The collaboration aimed to develop and commercialize companion diagnostic (CDx) assays for their utilization with AstraZeneca’s therapies. The partnership first concentrates on creating complementary diagnostic tools to recognize people with high-risk, early-stage diseases. Over the following few years, it is anticipated that additional studies will be conducted across various indications. Patients enrolled in AstraZeneca’s clinical trials will be tested using GRAIL’s methylation platform.
Apr-2022: Teva Pharmaceuticals signed a partnership with Roche Pharma China for improving lymphoma treatments by integrating the respective strengths and resources for further expanding the availability of Treanda in China. Following the partnership, the latter company reinforced its hematology portfolio and expanded the panorama of lymphoma treatment. Moreover, the companies work together for promoting the standardization of lymphoma treatment in China.
Mergers and Acquisitions:
Jan-2023: AstraZeneca acquired Neogene Therapeutics, Inc., a clinical-stage biotechnology company. Neogene’s experience in TCR-T discovery, development, and manufacturing would support AstraZeneca’s vision to change patient outcomes as part of a shared mission to provide cell treatments to patients with solid tumors. With the help of this acquisition, the former company’s internal oncology cell therapy team will have a rare opportunity to collaborate with world-renowned experts in T-cell receptor biology and cell therapy manufacturing, opening up new avenues for the treatment of cancer.
Aug-2022: AstraZeneca took over TeneoTwo, Inc. (TeneoTwo)i, with TNB-486, Phase I clinical-stage CD19/CD3 T-cell engager, which is currently under evaluation in relapsed and refractory B-cell non-Hodgkin lymphoma. With the acquisition of TNB-486, a potential novel treatment for B-cell hemotologic malignancies like diffuse large B-cell lymphoma and follicular lymphoma is being created. Building on the success of Calquence (acalabrutinib), TNB-486 broadens AstraZeneca’s hematology portfolio, which includes several therapeutic modalities and routes to target a variety of blood cancers.
Aug-2022: Bristol Myers Squibb completed the acquisition of Turning Point Therapeutics, a pharmaceutical company engaged in the discovery and development of precision medicine for cancer and other diseases. The acquisition added a product line of investigational medicines designed for targeting the most common mutations related to oncogenesis, to Bristol Myers’ portfolio.
Nov-2021: Pfizer acquired Trillium Therapeutics, a clinical-stage immuno-oncology company that develops innovative therapies for cancer treatment. The acquisition added a biologics portfolio that enhanced the patient’s innate immune system ability to detect and destroy cancer cells.
Product Launches and Expansions:
Mar-2023: Teva Pharmaceuticals together with NATCO Pharma Limited, announced the additional strengths for the generic version of Revlimid?1 (lenalidomide capsules), in 2.5 mg, and 20 mg strengths, in the United States. Teva’s lenalidomide capsules can be utilized for the treatment of multiple myeloma when combined with dexamethasone, specific myelodysplastic syndromes, and mantle cell lymphoma after receiving specific prior treatment.
Trials and Approvals:
Mar-2023: AstraZeneca received approval from National Medical Products Administration (NMPA) in China for Calquence (acalabrutinib), a next-generation, selective Bruton’s tyrosine kinase (BTK) inhibitor. This inhibitor is indicated for the treatment of mantale cell lymphoma in adult patients who have already obtained the therapy at least once.
Jan-2023: Eli Lilly and Company announced that U.S. FDA approved Jaypirca? (pirtobrutinib), the First and Only Non-Covalent (Reversible) BTK Inhibitor. The inhibitor would be used for the treatment of Relapsed or Refractory Mantle Cell Lymphoma After At least Two Lines of Systemic Therapy, Including a BTK Inhibitor, among adult patients.
Nov-2022: Seagen announced that U.S. FDA approved ADCETRIS? (brentuximab vedotin), the new indication for children with untreated high-risk Hodgkin lymphoma. It is suitable for the treatment of pediatric patients 2 years and above.
Aug-2022: AstraZeneca got the approval from US Food and Drug Administration (FDA) for its new tablet formulation of Calquence (acalabrutinib). This tablet formulation provides enhanced flexibility to patients and physicians when making treatment plans for chronic lymphocytic leukemia and mantle cell lymphoma.
Jun-2022: Bristol Myers Squibb got approval from U.S. FDA for CAR T Cell Therapy Breyanzi? for Relapsed or Refractory Large B-cell Lymphoma after a Prior Therapy once. This therapy is indicated for the treatment of follicular lymphoma grade 3B, primary mediastinal large B-cell lymphoma, large B-cell lymphoma (LBCL), including diffuse large B-cell lymphoma (DLBCL) not otherwise specified (including DLBCL arising from indolent lymphoma), and high-grade B-cell lymphoma, among adult patients.
Apr-2022: Kite, a Gilead Company, got approval from U.S. Food and Drug Administration (FDA) for Yescarta? (axicabtagene ciloleucel) CAR T-cell therapy. The therapy is beneficial for adult patients with large B-cell lymphoma that is refractory to first-line chemoimmunotherapy or that relapses within 12 months of first-line chemoimmunotherapy.
Feb-2021: Bristol Myers received U.S. Food and Drug Administration approval for Breyanzi (lisocabtagene maraleucel), a cell-based gene therapy. The therapy is indicated for the treatment of adult patients suffering from large B-cell lymphoma. This therapy is suitable for patients who have not responded to, or who have relapsed after, at least two other types of systemic treatment.
Jan-2021: Pfizer got U.S. Food and Drug Administration (FDA) approval for the supplemental New Drug Application (sNDA) for XALKORI? (crizotinib). This drug would be utilized for the treatment of pediatric patients 1 year and older and young adults with refractory or relapsed, systemic anaplastic large cell lymphoma (ALCL) that is anaplastic lymphoma kinase (ALK)-positive.
Scope of the Study
Market Segments covered in the Report:
By Treatment Type


    • Immune Therapy
    • Target Therapy
    • Chemotherapy
    • Radiation Therapy


By Disease Type


  • • Non-Hodgkin Lymphoma
    • Hodgkin Lymphoma


By Route of Administration


  • • Injectable
    • Oral Route


By Distribution Channel


  • • Hospital Pharmacies
    • Retail Pharmacies
    • Others


By Geography


  • • North America


o US
o Canada
o Mexico
o Rest of North America


  • • Europe


o Germany
o UK
o France
o Russia
o Spain
o Italy
o Rest of Europe


  • • Asia Pacific


o China
o Japan
o India
o South Korea
o Singapore
o Malaysia
o Rest of Asia Pacific


  • • LAMEA


o Brazil
o Argentina
o UAE
o Saudi Arabia
o South Africa
o Nigeria
o Rest of LAMEA
Companies Profiled


  • • AstraZeneca PLC
    • Bayer AG
    • Bristol Myers Squibb Company
    • F. Hoffmann-La Roche Ltd.
    • Johnson & Johnson
    • Gilead Sciences, Inc.
    • Seagen, Inc.
    • Teva Pharmaceutical Industries Ltd.
    • Pfizer, Inc.
    • Eli Lilly And Company


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