“T-cell Surface Glycoprotein CD4 – Pipeline Insight, 2020,” report provides comprehensive insights about 15+ companies and 15+ pipeline drugs in T-cell Surface Glycoprotein CD4 pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
Geography Covered
• Global coverage
T-cell Surface Glycoprotein CD4 Understanding
T-cell Surface Glycoprotein CD4: Overview
In molecular biology, CD4 (cluster of differentiation 4) is a glycoprotein found on the surface of immune cells such as T helper cells, monocytes, macrophages, and dendritic cells. It was discovered in the late 1970s and was originally known as leu-3 and T4 (after the OKT4 monoclonal antibody that reacted with it) before being named CD4 in 1984. In humans, the CD4 protein is encoded by the CD4 gene. CD4+ T helper cells are white blood cells that are an essential part of the human immune system. They are often referred to as CD4 cells, T-helper cells or T4 cells. They are called helper cells because one of their main roles is to send signals to other types of immune cells, including CD8 killer cells, which then destroy the infectious particle. If CD4 cells become depleted, for example in untreated HIV infection, or following immune suppression prior to a transplant, the body is left vulnerable to a wide range of infections that it would otherwise have been able to fight.
Structure of T-cell Surface Glycoprotein CD4
Like many cell surface receptors/markers, CD4 is a member of the immunoglobulin superfamily. It has four immunoglobulin domains (D1 to D4) that are exposed on the extracellular surface of the cell:
- D1 and D3 resemble immunoglobulin variable (IgV) domains.
- D2 and D4 resemble immunoglobulin constant (IgC) domains.
The immunoglobulin variable (IgV) domain of D1 adopts an immunoglobulin-like sandwich fold with seven strands in 2 sheets, in a Greek key topology.
Function
CD4 is a co-receptor of the T cell receptor (TCR) and assists the latter in communicating with antigen-presenting cells. The TCR complex and CD4 bind to distinct regions of the antigen-presenting MHC class II molecule. The extracellular D1 domain of CD4 binds to the ?2 region of MHC class II. The resulting close proximity between the TCR complex and CD4 allows the tyrosine kinase Lck bound to the cytoplasmic tail of CD4 to phosphorylate tyrosine residues of immunoreceptor tyrosine activation motifs (ITAMs) on the cytoplasmic domains of CD3 to amplify the signal generated by the TCR.
T-cell Surface Glycoprotein CD4 Emerging Drugs Chapters
This segment of the T-cell Surface Glycoprotein CD4 report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.
T-cell Surface Glycoprotein CD4 Emerging Drugs
- SAR441236: Sanofi
HIV in a person’s blood.
- Myelin oligodendrocyte glycoprotein transduced T cell therapy: ImCyse
Further product details are provided in the report
T-cell Surface Glycoprotein CD4: Therapeutic Assessment
This segment of the report provides insights about the different T-cell Surface Glycoprotein CD4 drugs segregated based on following parameters that define the scope of the report, such as:
- Major Players in T-cell Surface Glycoprotein CD4
Phases
The report covers around 15+ products under different phases of clinical development like
- Late-stage products (Phase II and Phase II/III)
- Mid-stage products (Phase II and Phase II/III)
- Early-stage products (Phase I/II and Phase I) along with the details of
- Pre-clinical and Discovery stage candidates
- Discontinued & Inactive candidates
- Route of Administration
- Intramuscular
- Intravenous
- Subcutaneous
- Molecule Type
- Monoclonal antibodies
- Cell-Therapies
- Tri-specific Antibodies
- Product Type
Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.
T-cell Surface Glycoprotein CD4: Pipeline Development Activities
The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses T-cell Surface Glycoprotein CD4 therapeutic drugs key players involved in developing key drugs.
Pipeline Development Activities
The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging T-cell Surface Glycoprotein CD4 drugs.
Report Highlights
T-cell Surface Glycoprotein CD4 Report Insights
- T-cell Surface Glycoprotein CD4 Pipeline Analysis
- Therapeutic Assessment
- Unmet Needs
- Impact of Drugs
- T-cell Surface Glycoprotein CD4 Report Assessment
- Pipeline Product Profiles
- Therapeutic Assessment
- Pipeline Assessment
- Inactive drugs assessment
- Unmet Needs
Key Questions
Current Treatment Scenario and Emerging Therapies:
- How many companies are developing T-cell Surface Glycoprotein CD4 drugs?
- How many T-cell Surface Glycoprotein CD4 drugs are developed by each company?
- How many emerging drugs are in mid-stage, and late-stage of development for the treatment of T-cell Surface Glycoprotein CD4?
- What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the T-cell Surface Glycoprotein CD4 therapeutics?
- What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
- What are the clinical studies going on for T-cell Surface Glycoprotein CD4 and their status?
- What are the key designations that have been granted to the emerging drugs?
- Biotest AB
- Bristol-Myers Squibb
- CEL-SCI Corp
- Evotec
- Immupharma Plc
- TaiMed Biologics
- United Biomedical
- CEL-1000
- Forigerimod acetate
- Ibalizumab
- M-48U1
- MAX-16H5
- SAR-441236
- TMB-360
- TMB-365
- Tregalizumab