The research provides technological advances and insights across non-opioid pharmaceuticals for the management of pain. Key application areas explored in the research include neuropathic pain, migrane, post-surgical pain, cancer pain, chronic pain and migraine. The research encompasses technological advances across Nav1.7 inhibitors, Calcitonin Gene-related peptide inhibitors, Platelet rich plasma therapy, Ditans, Hydrogel therapy, and stem cell therapy among several others.The research also provides competitive intelligence across emerging innovators in this space, while provide insights across the patent landscape for non-narcotic pain therapy.