Neuromodulation devices are used for regulating the nervous system to help alleviate pain, or control the
symptoms of Parkinson’s, urinary urge incontinence or gastroparesis, among several others. Therapy can
be delivered by electrically stimulating nerves or by targeted drug therapy, the latter of which does not
fall within the scope of this analysis. Neuromodulation systems discussed in this report consist of an
implantable pulse generator connected to one or more leads, which have electrodes on their opposite
ends. The electrodes are connected to nerves or tissue desired for stimulation, and the implanted
generator then delivers small pulses of electricity from an internal battery to the indicated area. This report
covers the global markets for spinal cord stimulation (SCS), sacral nerve stimulation (SNS), deep brain
stimulation (DBS), vagus nerve stimulation (VNS) and gastric electric stimulation (GES).

The full report suite on the global market for neuromodulation devices includes spinal cord
stimulators, deep brain stimulators, vagus nerve stimulators, sacral nerve stimulators and gastric
electric stimulators.