Table of Content

1. Introduction to PIM Kinase Targeted Therapy
1.1 Overview
1.2 History, Development & Evolution


2. PIM Kinase Targeted Therapy Approaches
2.1 Small Molecule Inhibitors
2.2 PROTAC Degraders
2.3 RNA Interference
2.4 CRISPR/Cas9


3. PIM Kinase Targeted Therapy Combinations for Cancer Treatment
3.1 Chemotherapy
3.2 Targeted Therapies
3.3 Radiotherapy
3.4 Immunotherapy


4. PIM Kinases as Diagnostic & Prognostic Markers


5. Global PIM Kinase Targeted Therapies Research & Market Trends by Indication
5.1 Cancer
5.2 Autoimmune & Inflammatory Disorders
5.3 Cardiovascular Diseases
5.4 Viral Diseases
5.5 Neurodegenerative Diseases


6. PIM Kinase Therapies - Proprietary Development Technologies By Companies


7. Global PIM Kinase Targeted Therapies Market Overview
7.1 Current Market Scenario
7.2 Future Commercialization Outlook
7.3 Favorable Developmental Parameters
7.4 Key Challenges & Restraints


8. PIM Kinase Targeted Therapies Research & Development Trends By Region
8.1 US
8.2 Europe
8.3 Japan
8.4 China


9. PIM Kinase Therapies – FDA Orphan Designation By Indication


10. Global PIM Kinase Inhibitor Clinical Trials Overview
10.1 By Phase
10.2 By Country
10.3 By Company
10.4 By Indication
10.5 Patient Segment


11. Global PIM Kinase Targeted Therapies Clinical Trials Insight By Company, Country, Indication & Phase
11.1 Preclinical
11.2 Phase I
11.3 Phase I/II
11.4 Phase II


12. Competitive Landscape
12.1 Akros Pharma
12.2 Biolexis Therapeutics
12.3 Inflection Biosciences
12.4 Menarini group
12.5 Mysthera Therapeutics
12.6 Novartis
12.7 Shengke Pharmaceutics
12.8 Sumitomo Pharma America

 



List of Figures

Figure 1-1: PIM Kinase Targeted Therapies – Developmental Milestones

Figure 2-1: PIM Kinase Targeted Therapy – Current Approaches
Figure 2-2: PIM Kinase Small Molecule Inhibition – Future Opportunities
Figure 2-3: PROTACs - Advantages
Figure 2-4: PROTACs – Future Opportunities
Figure 2-5: CRISPR/Cas9 – Benefits as a Therapeutic Modality
Figure 2-6: Effects of CRISPR/Cas9-mediated DSB repair mechanism on PIM Kinase activity

Figure 3-1: Combination of PIM Targeted Therapies & Chemotherapy - Benefits
Figure 3-2: Combination of PIM Targeted therapies & Immunotherapy - Benefits

Figure 5-1: PIM Kinases – Functions in Viral Infections

Figure 6-1: Biolexis Therapeutics – MolecuLern Process

Figure 7-1: PIM Kinase Targeted Therapies – Future Opportunities
Figure 7-2: Global PIM Kinase Targeted Therapies Market – Drivers & Opportunities
Figure 7-3: Global PIM Kinase Targeted Therapies Market – Challenges & Restraints

Figure 9-1: Regulatory Designations - Benefits

Figure 10-1: Global – PIM Kinase Targeted Therapies Clinical Trials By Phase (Numbers), 2024
Figure 10-2: Global – PIM Kinase Targeted Therapies Clinical Trials By Country (Numbers), 2024
Figure 10-3: Global – PIM Kinase Targeted Therapies Clinical Trials By Company (Numbers), 2024
Figure 104: Global – PIM Kinase Targeted Therapies Clinical Trials By Indication (Numbers), 2024
Figure 10-5: Global – PIM Kinase Targeted Therapies Clinical Trials By Patient Segment (Numbers), 2024

List of Tables

Table 5-1: Cancer - PIM inhibitors in Clinical Development
Table 5-2: Autoimmune & Inflammatory Disorders – PIM inhibitors in Clinical Development
Table 5-3: Cardiovascular Diseases – PIM inhibitors in Clinical Development
Table 9-1: PIM Kinase Therapies – FDA Orphan Designation By Indication