Table of Content

Chapter 1 Executive Summary
Market Outlook
Scope of Report
Market Insights

Chapter 2 Market Overview
Definitions
History of Oligonucleotide Synthesis
First Dinucleotide
Solid Phase Synthesis
Types of Oligonucleotides
DNA Probes
RNA Probes
Oligonucleotide Synthesis Processes
Solid Phase Chemical Synthesis
Alternative Forms of Oligonucleotide Synthesis
Versatile Functions of Synthetic Oligonucleotides
Regulatory Paths for Oligotherapeutics
Animal Models and Studies
Role of Regulatory Authorities

Chapter 3 Market Dynamics
Drivers
Increasing Use of Synthesized Oligos in Therapeutic Applications
Rising Government Investments for Synthetic Biology and Genome Projects
Growing Focus on Personalized Medicine
Restraints
Complexities Associated with Oligos
Lack of Clear Regulatory Infrastructure
Opportunities
Expansion of Companies
Emerging Applications in Various Fields

Chapter 4 Emerging Technologies and Developments
Overview
DNA Synthesizers
Emerging Technologies
Microfluidics Approach
Enzymatic De Novo DNA Synthesis

Chapter 5 Market Segmentation Analysis
Segmentation Breakdown
Global Market for Oligonucleotide Synthesis, by Product Type
Oligonucleotide Drugs
Equipment and Reagents
Synthesized Oligos
Services
Global Market for Oligonucleotide Synthesis, by Application
Research
Diagnostics and Therapeutics
Geographic Breakdown
Global Market for Oligonucleotide Synthesis, by Region
North America
Europe
Asia-Pacific
Rest of the World

Chapter 6 Competitive Intelligence
Competitive Landscape
Patent Analysis
M&A Analysis
Funding Outlook
Industry Structure

Chapter 7 ESG Development
Introduction to ESG
Assessing the Sustainability of the Oligonucleotide Manufacturing Process
Assessment Against the 12 Principles of Green Chemistry
Process Mass Intensity (PMI) Assessment
Assessment of Compounds Used in Oligonucleotide Manufacture
ESG Performance in Market

Chapter 8 Appendix
Methodology
Company Profiles
AGILENT TECHNOLOGIES INC.
BIOLEGIO B.V.
BIOLYTIC LAB PERFORMANCE INC.
EUROFINS SCIENTIFIC
GENSCRIPT
INTEGRATED DNA TECHNOLOGIES INC.
LC SCIENCES
LGC GROUP
MERCK KGAA
MICROSYNTH AG
THERMO FISHER SCIENTIFIC INC.



List of Figures


Summary Figure : Global Market Shares of Oligonucleotides, by Region, 2022
Figure 1 : History of the Solid-Phase Synthesis of Oligonucleotide
Figure 2 : Summary of Solid-Phase Oligonucleotide Synthesis Cycle
Figure 3 : Classification of Synthetic Oligonucleotides
Figure 4 : Dynamics of the Global Market for Oligonucleotides
Figure 5 : Global Market Shares of Oligonucleotide Synthesis, by Product Type, 2022
Figure 6 : Global Market for Oligonucleotide Drugs, 2020-2028
Figure 7 : Global Market for Oligonucleotide Drugs, by Region, 2020-2028
Figure 8 : Global Market for Equipment and Reagents, 2020-2028
Figure 9 : Global Market for Equipment and Reagents, by Region, 2020-2028
Figure 10 : Global Market for Synthesized Oligos, 2020-2028
Figure 11 : Global Market for Synthesized Oligos, by Region, 2020-2028
Figure 12 : Global Market for Services, 2020-2028
Figure 13 : Global Market for Services, by Region, 2020-2028
Figure 14 : Global Market Shares of Oligonucleotide Synthesis, by Application, 2022
Figure 15 : Global Market for Research Applications, 2020-2028
Figure 16 : Global Market for Research Applications, by Region, 2020-2028
Figure 17 : Global Market for Diagnostic and Therapeutic Applications, 2020-2028
Figure 18 : Global Market for Diagnostics and Therapeutics, by Region, 2020-2028
Figure 19 : Global Market for Oligonucleotide Synthesis, by Region, 2020-2028
Figure 20 : North American Market Shares of Oligonucleotide Synthesis, by Product Type, 2022
Figure 21 : North American Market Shares of Oligonucleotide Synthesis, by Application, 2020
Figure 22 : North American Market Shares of Oligonucleotide Synthesis, by Country, 2022
Figure 23 : European Market Shares of Oligonucleotide Synthesis, by Product Type, 2022
Figure 24 : European Market Shares of Oligonucleotide Synthesis, by Application, 2022
Figure 25 : European Market Shares of Oligonucleotide Synthesis, by Country, 2022
Figure 26 : Asia-Pacific Market Shares of Oligonucleotide Synthesis, by Product Type, 2022
Figure 27 : Asia-Pacific Market Shares of Oligonucleotide Synthesis, by Application, 2022
Figure 28 : Asia-Pacific Market Shares of Oligonucleotide Synthesis, by Country, 2022
Figure 29 : RoW Market Shares of Oligonucleotide Synthesis, by Product Type, 2022
Figure 30 : RoW Market Shares of Oligonucleotide Synthesis, by Application, 2022
Figure 31 : Drug Manufacturer Shares of Oligonucleotides, 2022
Figure 32 : Patent Applications and Patents Granted, 2000-2023
Figure 33 : Venture Capital Deals Including Corporate Pharma and Biotech Investors, by Year, 2010-2023
Figure 34 : How a Strong ESG Proposition Benefits Businesses
Figure 35 : ESG Adoption Level across Industries
Figure 36 : Agilent Technologies Inc.: Revenue Share, by Business Unit, FY 2023
Figure 37 : Agilent Technologies Inc.: Revenue Share, by Country/Region, FY 2023
Figure 38 : Eurofins Scientific: Revenue Share, by Country/Region, FY 2023
Figure 39 : GenScript: Revenue Share, by Business Unit, FY 2022
Figure 40 : GenScript: Revenue Share, by Country/Region, FY 2022
Figure 41 : LGC Group: Revenue Shares, by Business Unit, F.Y. 2023
Figure 42 : LGC Group: Revenue Share, by Country/Region, FY 2023
Figure 43 : Merck KGaA: Revenue Share, Business Unit, FY 2023
Figure 44 : Merck KGaA: Revenue Share, by Country/Region, FY 2023
Figure 45 : Thermo Fisher Scientific Inc.: Revenue Share, by Business Unit, FY 2023
Figure 46 : Thermo Fisher Scientific Inc.: Revenue Share, by Country/Region, FY 2023

List of Tables


Summary Table : Global Market for Oligonucleotides, by Region, Through 2028
Table 1 : History of Oligonucleotide Therapeutics, 1964-2013
Table 2 : Comparison of Oligonucleotide and Polynucleotide
Table 3 : Yield, Length and Coupling Efficiency of Oligonucleotide
Table 4 : List of Approved Oligonucleotide Therapeutics, 2023
Table 5 : Global Market for Oligonucleotide Synthesis, by Product Type, Through 2028
Table 6 : Global Market for Oligonucleotide Drugs, by Region, Through 2028
Table 7 : Revenue Generated, by Few Oligonucleotide Drugs, 2022
Table 8 : Global Market for Equipment and Reagents, by Region, Through 2028
Table 9 : Global Market for Synthesized Oligos, by Region, Through 2028
Table 10 : Pricing of Oligo Pools, by Twist Bioscience
Table 11 : Pricing for Oligo pools, by GenScript
Table 12 : Global Market for Services, by Region, Through 2028
Table 13 : Global Market for Oligonucleotide Synthesis, by Application, Through 2028
Table 14 : Global Market for Research Applications, by Region, Through 2028
Table 15 : Global Market for Diagnostic and Therapeutic Applications, by Region, Through 2028
Table 16 : Global Market for Oligonucleotide Synthesis, by Region, Through 2028
Table 17 : North American Market for Oligonucleotide Synthesis, by Product Type, Through 2028
Table 18 : North American Market for Oligonucleotide Synthesis, by Application, Through 2028
Table 19 : North American Market for Oligonucleotide Synthesis, by Country, Through 2028
Table 20 : European Market for Oligonucleotide Synthesis, by Product Type, Through 2028
Table 21 : European Market for Oligonucleotide Synthesis, by Application, Through 2028
Table 22 : European Market for Oligonucleotide Synthesis, by Country, Through 2028
Table 23 : Asia-Pacific Market for Oligonucleotide Synthesis, by Product Type, Through 2028
Table 24 : Asia-Pacific Market for Oligonucleotide Synthesis, by Application, Through 2028
Table 25 : Asia-Pacific Market for Oligonucleotide Synthesis, by Country, Through 2028
Table 26 : RoW Market for Oligonucleotide Synthesis, by Product Type, Through 2028
Table 27 : RoW Market for Oligonucleotide Synthesis, by Application, Through 2028
Table 28 : Top Oligonucleotide Synthesis Manufacturers, 2022
Table 29 : Select Patents on Oligonucleotide Synthesis Published in 2020
Table 30 : Select Patents on Oligonucleotide Synthesis Published in 2021
Table 31 : Select Patents on Oligonucleotide Synthesis Published in 2022
Table 32 : Select Patents on Oligonucleotide Synthesis Published in 2023
Table 33 : Major Strategic Alliances in Oligonucleotide Synthesis Industry, 2023
Table 34 : Top Deals in Oligonucleotide Synthesis Industry, 2023
Table 35 : Antisense Oligonucleotides Cancer Therapeutics in Clinical Trials
Table 36 : siRNA Cancer Therapeutics in Clinal Trials
Table 37 : miRNA Cancer Therapeutics in Clinal Trials
Table 38 : Assessment of the Oligonucleotide Manufacturing Process Against the 12 Principles of Green Chemistry
Table 39 : Assessment of Compounds Used in Oligonucleotide Manufacture against the CHEM21 Solvent Guide
Table 40 : Key Focus Areas in ESG Metrics
Table 41 : ESG Rankings for Oligonucleotide Companies, 2023*
Table 42 : Acronyms Used in this Report
Table 43 : Agilent Technologies Inc.: Company Snapshot
Table 44 : Agilent Technologies Inc.: Financial Performance, F.Y. 2022 and 2023
Table 45 : Agilent Technologies Inc.: Product Portfolio
Table 46 : Agilent Technologies Inc.: News/Key Developments, 2022-2023
Table 47 : Biolegio B.V.: Company Snapshot
Table 48 : Biolegio B.V.: Product Portfolio
Table 49 : Biolytic Lab Performance Inc.: Company Snapshot
Table 50 : Biolytic Lab Performance Inc.: Product Portfolio
Table 51 : Biolytic Lab Performance Inc.: News/Key Developments, 2021
Table 52 : Eurofins Scientific: Company Snapshot
Table 53 : Eurofins Scientific: Financial Performance, FY 2022 and 2023
Table 54 : Eurofins Scientific: Product Portfolio
Table 55 : GenScript: Company Snapshot
Table 56 : GenScript: Financial Performance, FY 2021 and 2022
Table 57 : GenScript: Product Portfolio
Table 58 : GenScript: News/Key Developments, 2021-2023
Table 59 : Integrated DNA Technologies Inc.: Company Snapshot
Table 60 : Integrated DNA Technologies Inc.: Product Portfolio
Table 61 : Integrated DNA Technologies Inc.: News/Key Developments, 2021-2023
Table 62 : L.C. Sciences: Company Snapshot
Table 63 : L.C. Sciences: Product Portfolio
Table 64 : LGC Group: Company Snapshot
Table 65 : LGC Group: Financial Performance, FY 2022 and 2023
Table 66 : LGC Group: Product Portfolio
Table 67 : LGC Group: News/Key Developments, 2023
Table 68 : Merck KGaA: Company Snapshot
Table 69 : Merck KGaA: Financial Performance, FY 2022 and 2023
Table 70 : Merck KGaA: Product Portfolio
Table 71 : Merck KGaA: News/Key Developments, 2021
Table 72 : Microsynth AG: Company Snapshot
Table 73 : Microsynth AG: Product Portfolio
Table 74 : Microsynth AG: News/Key Developments, 2021-2023
Table 75 : Thermo Fisher Scientific Inc.: Company Snapshot
Table 76 : Thermo Fisher Scientific Inc.: Financial Performance, FY 2022 and 2023
Table 77 : Thermo Fisher Scientific Inc.: Product Portfolio
Table 78 : Thermo Fisher Scientific Inc.: News/Key Developments, 2021-2023