Table of Content

1. PREFACE
1.1. Scope of the Report
1.2. Research Methodology
1.3. Key Questions Answered
1.4. Chapter Outlines

2. EXECUTIVE SUMMARY

3. INTRODUCTION
3.1. Overview of Complement System
3.2. Immune Cells Involved in Complement System
3.3. Characteristics of Complement System
3.4. Functions of Complement System
3.5. Role of Complement in Homeostasis and Stress Conditions
3.6. Activation of Complement System
3.6.1. Steps in Complement Activation
3.7. Sources of Key Complement Proteins
3.8. Functions of Complement Proteins of Classical Pathway
3.9. Pathways of Complement System
3.9.1. Classical Pathway
3.9.2. Lectin Pathway
3.9.3. Alternative Pathway
3.9.4. Terminal Pathway
3.10. Consequences of a Dysregulated Complement System
3.11. Diseases related to Defects in Complement Proteins
3.12. Types of Complement Therapeutics
3.13. Limitations of Complement Therapeutics
3.14. Future of Next Generation Complement Therapeutics

4. NEXT GENERATION COMPLEMENT THERAPEUTICS: MARKET LANDSCAPE
4.1. Analysis Methodology and Key Parameters
4.2. Next Generation Complement Therapeutics: Development Pipeline
4.2.1. Analysis by Status of Development
4.2.2. Analysis by Type of Molecule
4.2.3. Analysis by Status of Development and Type of Molecule
4.2.4. Analysis by Type of Drug
4.2.5. Analysis by Biological Target
4.2.6. Analysis by Target Pathway
4.2.7. Analysis by Mechanism of Action
4.2.8. Analysis by Mechanism of Action and Target Pathway
4.2.9. Analysis by Target Disease Indication(s)
4.2.10. Analysis by Status of Development and Target Disease Indication(s)
4.2.11. Analysis by Therapeutic Area
4.2.12. Analysis by Therapeutic Area and Type of Molecule
4.2.13. Analysis by Route of Administration
4.2.14. Analysis by Type of Therapy
4.2.15. Analysis by Dosing Frequency
4.2.16. Grid Analysis: Type of Therapy, Type of Molecule, Route of Administration and Mechanism of Action
4.3. Next Generation Complement Therapeutics: List of Drugs with Special Designations
4.3.1. Analysis by Special Designation
4.4. Next Generation Complement Therapeutics: Developer Landscape
4.4.1. Analysis by Year of Establishment
4.4.2. Analysis by Company Size
4.4.3. Analysis by Region of Headquarters
4.4.4. Analysis by Company Size and Region of Headquarters
4.4.5. Leading Players: Analysis by Number of Therapeutics

5. COMPANY PROFILES
5.1. Amgen
5.1.1. Company Overview
5.1.2. Financial Information
5.1.3. Product Portfolio
5.1.4. Recent Developments and Future Outlook
5.2. CSL Behring
5.2.1. Company Overview
5.2.2. Financial Information
5.2.3. Product Portfolio
5.2.4. Recent Developments and Future Outlook
5.3. Innovent Biologics
5.3.1. Company Overview
5.3.2. Financial Information
5.3.3. Product Portfolio
5.3.4. Recent Developments and Future Outlook
5.4. Novartis
5.4.1. Company Overview
5.4.2. Financial Information
5.4.3. Product Portfolio
5.4.4. Recent Developments and Future Outlook
5.5. Regeneron
5.5.1. Company Overview
5.5.2. Financial Information
5.5.3. Product Portfolio
5.5.4. Recent Developments and Future Outlook
5.6. Roche
5.6.1. Company Overview
5.6.2. Financial Information
5.6.3. Product Portfolio
5.6.4. Recent Developments and Future Outlook
5.7. Sanofi
5.7.1. Company Overview
5.7.2. Financial Information
5.7.3. Product Portfolio
5.7.4. Recent Developments and Future Outlook
5.8. Takeda
5.8.1. Company Overview
5.8.2. Financial Information
5.8.3. Product Portfolio
5.8.4. Recent Developments and Future Outlook
5.9. UCB
5.9.1. Company Overview
5.9.2. Financial Information
5.9.3. Product Portfolio
5.9.4. Recent Developments and Future Outlook

6. CLINICAL TRIAL ANALYSIS
6.1. Analysis Methodology and Key Parameters
6.2. Next Generation Complement Therapeutics: List of Clinical Trials
6.2.1. Analysis by Trial Status
6.2.2. Cumulative Analysis by Trial Registration Year
6.2.3. Analysis by Trial Registration Year and Status
6.2.4. Analysis by Trial Phase
6.2.5. Analysis by Trial Phase and Patients Enrolled
6.2.6. Analysis by Trial Registration Year and Patients Enrolled
6.2.7. Analysis by Type of Sponsor / Collaborator
6.2.8. Analysis by Type of Study
6.2.9. Analysis by Study Design
6.2.10. Most Active Industry Players: Analysis by Number of Trials
6.2.11. Most Active Non-Industry Players: Analysis by Number of Trials
6.2.12. Analysis by Disease Indication
6.2.13. Most Popular Therapeutic Areas: Analysis by Number of Trials
6.2.14. Analysis by Type of Treatment
6.2.15. Analysis by Type of Drug
6.2.16. Word Cloud Analysis: Emerging Focus Areas
6.2.17. Analysis by Top Indications and Phase of the Trial
6.2.18. Analysis by Top Indications and Leading Industry Players
6.2.19. Analysis by Trial Location
6.2.20. Analysis by Geography and Trial Status

7. PUBLICATION ANALYSIS
7.1. Analysis Methodology and Key Parameters
7.2. Next Generation Complement Therapeutics: List of Publications
7.2.1. Analysis by Year of Publication
7.2.2. Word Cloud Analysis: Emerging Focus Areas
7.2.3. Top Authors: Analysis by Number of Publications
7.2.4. Key Journals based on Number of Publications
7.2.5. Key Journals based on Impact Factor
7.2.6. Popular Indications based on Number of Publications
7.2.7. Popular Therapeutic Areas based on Number of Publications

8. GRANT ANALYSIS
8.1. Analysis Methodology and Key Parameters
8.1.1. Analysis by Year of Grants Awarded
8.1.2. Analysis by Amount Awarded
8.1.3. Analysis by Funding Institute Center
8.1.4. Analysis by Support Period
8.1.5. Analysis by Funding Institute Center and Support Period
8.1.6. Analysis by Type of Grant
8.1.7. Analysis by Activity Code
8.1.8. Popular Recipient Organizations: Analysis by Number of Grants
8.1.9. Popular Recipient Organizations: Analysis by Amount Awarded
8.1.10. Popular NIH Departments: Analysis by Number of Grants
8.1.11. Analysis by Study Section
8.1.12. Analysis by Type of Recipient Organization
8.1.13. Word Cloud Analysis: Emerging Focus Areas
8.1.14. Analysis by Purpose of Grant
8.1.15. Prominent Program Officers: Analysis by Number of Grants
8.1.16. Analysis by Location of Recipient Organizations

9. PATENT ANALYSIS
9.1. Analysis Methodology and Key Parameters
9.2. Next Generation Complement Therapeutics: List of Patents
9.2.1. Analysis by Patent Publication Year
9.2.2. Analysis of Year-wise Granted Patents
9.2.3. Analysis by Type of Patent
9.2.4. Analysis by Granted Patents and Patent Applications
9.2.5. Analysis by Geography
9.2.6. Analysis by CPC Symbols
9.2.7. Analysis by Type of Applicant
9.2.8. Analysis of Patents by Age
9.2.9. Word Cloud Analysis: Emerging Focus Areas
9.2.10. Leading Industry Players: Analysis by Number of Patents
9.2.11. Leading Non-Industry Players: Analysis by Number of Patents
9.2.12. Leading Individual Assignees: Analysis by Number of Patents
9.2.13. Leading Players: Benchmarking by Patent Characteristics (CPC Symbols)
9.2.14. Patent Valuation: Analysis Methodology and Parameters
9.2.15. Patent Valuation: Analysis by Relative Valuation
10. PARTNERSHIPS AND COLLABORATIONS
10.1. Next Generation Complement Therapeutics: List of Partnerships and Collaborations
10.1.1. Analysis by Year-wise Trend of Partnership
10.1.2. Analysis by Type of Partnership
10.1.3. Analysis by Year and Type of Partnership
10.1.4. Most Popular Drug: Analysis by Number of Partnerships
10.1.5. Analysis by Biological Target
10.1.6. Analysis by Target Pathway
10.1.7. Word Cloud Analysis: Emerging Focus Areas
10.1.8. Analysis by Drug and Type of Partnership
10.1.9. Analysis by Type of Partner
10.1.10. Analysis by Popular Disease Indication
10.1.11. Analysis by Popular Disease Indication and Type of Partnership
10.1.12. Analysis by Therapeutic Area
10.1.13. Analysis by Therapeutic Area and Type of Partnership
10.1.14. Regional Analysis of Partnerships
10.1.15. Intercontinental and Intracontinental Agreements
11. FUNDING AND INVESTMENT ANALYSIS
11.1. Next Generation Complement Therapeutics: List of Funding and Investments
11.1.1. Cumulative Year-wise Trend
11.1.2. Analysis by Amount Invested per Year
11.1.3. Analysis by Type of Funding and Year of Establishment
11.1.4. Analysis of Instances by Type of Funding
11.1.5. Analysis of Amount Invested by Type of Funding
11.1.6. Analysis by Year, Type of Funding and Amount Invested
11.1.7. Most Active Investors: Analysis by Number of Instances
11.1.8. Most Active Players: Analysis by Number of Funding Instances
11.1.9. Most Active Players: Analysis by Amount Raised
11.1.10. Analysis of Amount by Drug
11.1.11. Analysis of Number of Instances by Drug
11.1.12. Summary of Investments

12. BIG PHARMA PLAYERS
12.1 Analysis Methodology and Key Parameters
12.2. Scoring of Parameters
12.3. Big Pharma Players: Information on Revenues Generated in 2021
12.3.1. Analysis by Supplier Strength
12.3.2. Analysis by Portfolio Strength
12.3.3. Analysis by Portfolio Diversity
12.3.4. Benchmarking: Spider Web Analysis
12.3.5. Benchmarking: Harvey Ball Analysis
12.3.6. Benchmarking: Wind Rose Chart

13. MARKET SIZING AND OPPORTUNITY ANALYSIS
13.1. Forecast Methodology and Key Parameters
13.2. Global Next Generation Complement Therapeutics Market, 2022-2035
13.3. Global Next Generation Complement Therapeutics Market for Marketed Drugs, 2022-2035
13.3.1. Next Generation Complement Therapeutics Market for Marketed Drugs, 2022-2035: Distribution by Target Disease Indication
13.3.1.1. Next Generation Complement Therapeutics Market for Paroxysmal Nocturnal Hemoglobinuria, 2022-2035
13.3.1.2. Next Generation Complement Therapeutics Market for Hereditary Angioedema, 2022-2035
13.3.2. Next Generation Complement Therapeutics Market for Marketed Drugs, 2022-2035: Distribution by Type of Molecule
13.3.2.1. Next Generation Complement Therapeutics Market for Biologics, 2022-2035
13.3.2.2. Next Generation Complement Therapeutics Market for Small Molecules, 2022-2035
13.3.3. Next Generation Complement Therapeutics Market for Marketed Drugs, 2022-2035: Distribution by Target Pathway
13.3.3.1. Next Generation Complement Therapeutics Market for Terminal Pathway, 2022-2035
13.3.3.2. Next Generation Complement Therapeutics Market for Classical Pathway, 2022-2035
13.3.3.3. Next Generation Complement Therapeutics Market for Alternate Pathway, 2022-2035
13.3.3.4. Next Generation Complement Therapeutics Market for Lectin Pathway, 2022-2035
13.3.4. Next Generation Complement Therapeutics Market for Marketed Drugs, 2022-2035: Distribution by Type of Therapy
13.3.4.1. Next Generation Complement Therapeutics Market for Monotherapy, 2022-2035
13.3.4.2. Next Generation Complement Therapeutics Market for Combination Therapy, 2022-2035
13.3.5. Next Generation Complement Therapeutics Market for Marketed Drugs, 2022-2035: Distribution by Route of Administration
13.3.5.1. Next Generation Complement Therapeutics Market for Intravenous Drugs, 2022-2035
13.3.5.2. Next Generation Complement Therapeutics Market for Subcutaneous Drugs, 2022-2035
13.3.5.3. Next Generation Complement Therapeutics Market for Oral Drugs, 2022-2035
13.4. Product-wise Sales Forecast for Marketed Drugs
13.4.1. Berinert (CSL Behring)
13.4.1.1. Sales Forecast (USD Billion)
13.4.2. EMPAVELI (Apellis Pharmaceuticals)
13.4.2.1. Sales Forecast (USD Billion)
13.4.3. ORLADEYO (BioCryst Pharmaceuticals)
13.4.3.1. Sales Forecast (USD Billion)
13.4.4. Ruconest (Pharming)
13.4.4.1. Sales Forecast (USD Billion)
13.4.5. Soliris (Alexion Pharmaceuticals)
13.4.5.1. Sales Forecast (USD Billion)
13.4.6. Takhzyro (Takeda)
13.4.6.1. Sales Forecast (USD Billion)
13.4.7. Ultomiris (Alexion Pharmaceuticals)
13.4.7.1. Sales Forecast (USD Billion)
13.5. Global Next Generation Complement Therapeutics Market for Phase III Drugs, 2022-2035
13.5.1. Next Generation Complement Therapeutics Market for Phase III Drugs, 2022-2035: Distribution by Target Disease Indication
13.5.1.1. Next Generation Complement Therapeutics Market for Atypical Hemolytic Uremic Syndrome, 2022-2035
13.5.1.2. Next Generation Complement Therapeutics Market for Cardiac Transplantation Rejection, 2022-2035
13.5.1.3. Next Generation Complement Therapeutics Market for Cold Agglutinin Disease, 2022-2035
13.5.1.4. Next Generation Complement Therapeutics Market for COVID-19, 2022-2035
13.5.1.5. Next Generation Complement Therapeutics Market for Guillain-Barre Syndrome, 2022-2035
13.5.1.6. Next Generation Complement Therapeutics Market for Generalized Myasthenia Gravis, 2022-2035
13.5.1.7. Next Generation Complement Therapeutics Market for Neuromyelitis Optica, 2022-2035
13.5.1.8. Next Generation Complement Therapeutics Market for Paroxysmal Nocturnal Hemoglobinuria, 2022-2035
13.5.2. Next Generation Complement Therapeutics Market for Phase III Drugs, 2022-2035: Distribution by Therapeutic Area
13.5.2.1. Next Generation Complement Therapeutics Market for Cardiovascular Disorders, 2022-2035
13.5.2.2. Next Generation Complement Therapeutics Market for Hematological and Vascular Disorders, 2022-2035
13.5.2.3. Next Generation Complement Therapeutics Market for Infectious Diseases, 2022-2035
13.5.2.4. Next Generation Complement Therapeutics Market for Neurological Disorders, 2022-2035
13.5.2.5. Next Generation Complement Therapeutics Market for Neuromuscular Disorders, 2022-2035
13.5.2.6. Next Generation Complement Therapeutics Market for Genetic Disorders, 2022-2035
13.5.3. Next Generation Complement Therapeutics Market for Phase III Drugs, 2022-2035: Distribution by Target Pathway
13.5.3.1. Next Generation Complement Therapeutics Market for Terminal Pathway, 2022-2035
13.5.3.2. Next Generation Complement Therapeutics Market for Lectin Pathway, 2022-2035
13.5.3.3. Next Generation Complement Therapeutics Market for Classical Pathway, 2022-2035
13.5.4. Next Generation Complement Therapeutics Market for Phase III Drugs, 2022-2035: Distribution by Type of Therapy
13.5.4.1. Next Generation Complement Therapeutics Market for Monotherapy, 2022-2035
13.5.4.2. Next Generation Complement Therapeutics Market for Combination Therapy, 2022-2035
13.5.5. Next Generation Complement Therapeutics Market for Phase III Drugs, 2022-2035: Distribution by Route of Administration
13.5.5.1. Next Generation Complement Therapeutics Market for Intravenous Drugs, 2022-2035
13.5.5.2. Next Generation Complement Therapeutics Market for Subcutaneous Drugs, 2022-2035
13.5.6. Next Generation Complement Therapeutics Market for Phase III Drugs, 2022-2035: Distribution by Geography
13.5.6.1. Next Generation Complement Therapeutics Market in North America, 2022-2035
13.5.6.1.1. Next Generation Complement Therapeutics Market in US, 2022-2035
13.5.6.1.2. Next Generation Complement Therapeutics Market in Canada, 2022-2035
13.5.6.2. Next Generation Complement Therapeutics Market in Europe, 2022-2035
13.5.6.2.1. Next Generation Complement Therapeutics Market in UK, 2022-2035
13.5.6.2.2. Next Generation Complement Therapeutics Market in Germany, 2022-2035
13.5.6.2.3. Next Generation Complement Therapeutics Market in France, 2022-2035
13.5.6.2.4. Next Generation Complement Therapeutics Market in Italy, 2022-2035
13.5.6.2.5. Next Generation Complement Therapeutics Market in Spain, 2022-2035
13.5.6.3. Next Generation Complement Therapeutics Market in Asia Pacific, 2022-2035
13.5.6.3.1. Next Generation Complement Therapeutics Market in Australia, 2022-2035
13.5.6.3.2. Next Generation Complement Therapeutics Market in Japan, 2022-2035
13.5.6.3.3. Next Generation Complement Therapeutics Market in China, 2022-2035
13.5.6.3.4. Next Generation Complement Therapeutics Market in India, 2022-2035
13.6. Product-wise Sales Forecast for Phase III Drugs
13.6.1. Narsoplimab (Omeros)
13.6.1.1. Target Patient Population
13.6.1.2. Sales Forecast (USD Billion)
13.6.1.3. Net Present Value (USD Billion)
13.6.1.4. Value Creation Analysis
13.6.2. REGN3918 (Regeneron)
13.6.2.1. Target Patient Population
13.6.2.2. Sales Forecast (USD Billion)
13.6.2.3. Net Present Value (USD Billion)
13.6.2.4. Value Creation Analysis
13.6.3. RG6107 (Ruconest)
13.6.3.1. Target Patient Population
13.6.3.2. Sales Forecast (USD Billion)
13.6.3.3. Net Present Value (USD Billion)
13.6.3.4. Value Creation Analysis
13.6.4. rVA576 (Akari Therapeutics)
13.6.4.1. Target Patient Population
13.6.4.2. Sales Forecast (USD Billion)
13.6.4.3. Net Present Value (USD Billion)
13.6.4.4. Value Creation Analysis
13.6.5. SAR445088 (Sanofi)
13.6.5.1. Target Patient Population
13.6.5.2. Sales Forecast (USD Billion)
13.6.5.3. Net Present Value (USD Billion)
13.6.5.4. Value Creation Analysis
13.6.6. Soliris (Alexion Pharmaceuticals)
13.6.6.1. Target Patient Population
13.6.6.2. Sales Forecast (USD Billion)
13.6.6.3. Net Present Value (USD Billion)
13.6.6.4. Value Creation Analysis
13.6.7. Sutimlimab (Bioverativ)
13.6.7.1. Target Patient Population
13.6.7.2. Sales Forecast (USD Billion)
13.6.7.3. Net Present Value (USD Billion)
13.6.7.4. Value Creation Analysis
13.6.8. Vilobelimab (InflaRx)
13.6.8.1. Target Patient Population
13.6.8.2. Sales Forecast (USD Billion)
13.6.8.3. Net Present Value (USD Billion)
13.6.8.4. Value Creation Analysis
13.6.9. Zilucoplan (UCB)
13.6.9.1. Target Patient Population
13.6.9.2. Sales Forecast (USD Billion)
13.6.9.3. Net Present Value (USD Billion)
13.6.9.4. Value Creation Analysis
13.7. Summary: Phase III Drugs

14. EXPERT OPINION
14.1. New York Oncology Hematology
14.1.1. Overview of Organization
14.1.2. Expert Opinion: Mihir Raval (Physician)
14.2. Cedars-Sinai Tower Hematology Oncology Medical
14.2.1. Overview of Organization
14.2.2. Expert Opinion: Jeremy Lorber (Hematologist Oncologist)
14.3. Weill Cornell Medical College
14.3.1. Overview of Organization
14.3.2. Expert Opinion: Jeffrey Conrad Laurence (Senior Scientific Consultant)
14.4. Leiden University Medical Center
14.4.1. Overview of Organization
14.4.2. Expert Opinion: YKO (Onno) Teng (Nephrology Clinician-Scientist
14.5. Lund University
14.5.1. Overview of Organization
14.5.2. Expert Opinion: M?rten Segelmark (Professor of Nephrology)

15. APPENDIX 1: LIST OF FIGURES AND TABLES

16. APPNEDIX 2: LIST OF COMPANIES AND ORGANIZATIONS