Table of Content

Frequent Abbreviations


1 Executive Summary


2 Overview and Methodology


3 Discovery, Structure and Function of Claudin 18.2

3.1 Discovery of Claudin 18.2 as a highly lineage-specific cancer target
3.2 Structure and Function of Claudin 18.2


4 Expression Profile of Claudin 18.2 in Cancer

4.1 CLDN18.2 expression in gastric and gastro-esophageal junction (GEJ) cancer
4.2 CLDN18.2 expression in gastric, GEJ, pancreatic and other cancers
4.3 Summary of CLDN18.2 Expression in Cancer


5 Incidence of gastric, esophageal and pancreatic cancer

5.1 Gastric cancer
5.2 Esophageal cancer
5.3 Pancreatic cancer


6 CLDN18.2 Licensing Agreements


7 Analysis of Claudin 18.2 Stakeholders

7.1 Major Biopharmaceutical Companies outside of China with CLDN18.2 Programs
7.2 Other Biopharmaceutical Companies outside of China with CLDN18.2 Programs
7.3 Chinese Biopharmaceutical Companies with Clinical Development of CLDN18.2 Programs outside of China
7.4 Chinese Biopharmaceutical Companies with Clinical Development of CLDN18.2 Programs inside of China
7.5 Chinese Biopharmaceutical Companies with Non-Clinical & Preclinical R&D of CLDN18.2 Programs


8 Pipeline Analysis of CLDN18.2-Targeted Immunotherapy Candidates

8.1 CLDN18.2 Drug Modalities and Development Stage
8.2 Discontinued CLDN18.2 R&D Programs
8.3 Zolbetuximab as Benchmark for CLDN18.2-Targeted Immunotherapies
8.4 CLDN18.2-Targeted Naked Monoclonal Antibodies
8.4.1 Clinical Experience with Anti-CLDN18.2 Naked Monoclonal Antibodies
8.5 CLDN18.2 Targeted Antibody-Drug Conjugates (ADCs)
8.5.1 Clinical Experience with Anti-CLDN18.2 Antibody-Drug Conjugates
8.6 CLDN18.2 Targeted Chimeric Antigen Receptor T-cells (CAR-T)
8.6.1 Clinical Experience with Anti-CLDN18.2 CAR T-Cells
8.7 CLDN18.2 Targeted Bispecific T-Cell Engaging Antibodies
8.8 CLDN18.2 Targeted Bispecific Immuno-Oncology (I-O) Antibodies
8.8.1 CLDN18.2 x 4-1BB Bispecific Antibodies
8.8.2 CLDN18.2 x CD47 / SIRP? Bispecific Antibodies
8.8.3 CLDN18.2 x PD-L1 Bispecific Antibodies
8.8.4 CLDN18.2 x CD8 Bispecific Antibodies


9 Company Profiles

9.1 Major Biopharmaceutical Companies outside of China
9.1.1 Astellas Pharma
9.1.2 AstraZeneca
9.1.3 BioNTech
9.1.4 Bristol Myers Squibb
9.1.5 Merck
9.1.6 Roche

9.2 Other Biopharmaceutical Companies outside of China
9.2.1 ABL Bio
9.2.2 Abpro
9.2.3 CARTEXEL
9.2.4 Elevation Oncology
9.2.5 Integral Molecular
9.2.6 Leap Therapeutics
9.2.7 Phanes Therapeutics
9.2.8 SOTIO Biotech
9.2.9 TORL BioTherapeutics
9.2.10 Triumvira Immunologcics

9.3 Chinese Biopharmaceutical Companies with Clinical Development outside of China
9.3.1 Antengene
9.3.2 CARsgen Therapeutics
9.3.3 I-Mab Biopharma
9.3.4 Innovent Biologics
9.3.5 Jiangsu Hengrui Pharmaceuticals
9.3.6 La Nova Medicines
9.3.7 RemeGen
9.3.8 SparX Group
9.3.9 Transcenta Holding
9.3.10 Zai Lab

9.4 Chinese Biopharmaceutical Companies with Clinical Development inside China
9.4.1 Beijing Mabworks Biotech
9.4.2 Biotheus
9.4.3 CSPC Pharmaceutical Group
9.4.4 Gracell Biotechnologies
9.4.5 Jiangsu Aosaikang Pharmaceutical
9.4.6 L&L Biopharma
9.4.7 Legend Biotech
9.4.8 Nanjing Kaedi Biotherapeutics
9.4.9 Qilu Pharmaceutical
9.4.10 QureBio
9.4.11 Shandong Boan Biotechnology
9.4.12 Shanghai Junshi Biosciences
9.4.13 Shanghai Longyao Biotechnology
9.4.14 Sichuan Kelun-Biotech Biopharmaceutical
9.4.15 Suzhou Immunofoco Biotechnology
9.4.16 Zhejiang Doer Biologics

9.5 Chinese Biopharmaceutical Companies with Non-Clinical and Preclinical R&D
9.5.1 Akeso
9.5.2 Dragon Boat Biopharmaceutical
9.5.3 Elpiscience Biopharmaceutical
9.5.4 Genor Biopharma
9.5.5 OriCell Therapeutics
9.5.6 Shanghai Genbase Biotechnology


10 Anti-CLDN18.2 Drug Candidate Profiles

10.1 Naked Monoclonal Antibodies
10.1.1 AB011
10.1.2 ASKB589
10.1.3 BA1105
10.1.4 BC008
10.1.5 BNT141
10.1.6 DR30303
10.1.7 GB7004
10.1.8 IBI360
10.1.9 JS012
10.1.10 LM-102
10.1.11 MIL93
10.1.12 NBL-015; FL-301
10.1.13 Osemitamab; TST001
10.1.14 SPX-101
10.1.15 TORL-2-307-MAB
10.1.16 ZL-1211
10.1.17 Zolbetuximab

10.2 Antibody-Drug Conjugates
10.2.1 ATG-022
10.2.2 BA1301
10.2.3 CMG901
10.2.4 IBI343
10.2.5 JS107
10.2.6 LM-302; BMS-986476; TPX-4589
10.2.7 RC118
10.2.8 SHR-A1904
10.2.9 SKB315
10.2.10 SOT102
10.2.11 SYSA1801; EO-3021
10.2.12 TORL-2-307-ADC

10.3 Chimeric Antigen Receptor T-Cells
10.3.1 BNT212
10.3.2 CT041
10.3.3 CT048
10.3.4 GC506
10.3.5 IBI345
10.3.6 IMC002
10.3.7 KD-496
10.3.8 LB1908
10.3.9 LY011
10.3.10 PM3023
10.3.11 TAC01-CLDN18.2

10.4 Bispecific T-Cell Engaging Antibodies
10.4.1 ABP-150
10.4.2 ASP2138
10.4.3 GB264
10.4.4 Gresonitamab; AMG 910
10.4.5 HBM7022; AZD5863
10.4.6 IBI389
10.4.7 QLS31905
10.4.8 WB67

10.5 CLDN18.2 Targeted Bispecific Immuno-Oncology (I-O) Antibodies
10.5.1 CLDN18.2 x 4-1BB Bispecific Antibodies
10.5.1.1 FL-302; NBL-016
10.5.1.2 Givastomig
10.5.1.3 PM1032
10.5.2 CLDN18.2 x CD47 / SIRP? Bispecific Antibodies
10.5.2.1 BC007
10.5.2.2 ES028
10.5.2.3 PT886
10.5.3 CLDN18.2 x PD-L1 Bispecific Antibodies
10.5.3.1 Q-1802
10.5.3.2 TST006


11 References

ADDENDUM