Table of Content

1. Introduction to Poly (ADP-Ribose) Polymerase Inhibitors
1.1 PARP Inhibitors as Unique Cancer Therapy
1.2 Evolutionary Aspects of PARP Inhibitors


2. PARP Proteins: An Attractive Target for Developing Cancer Therapeutics
2.1 Structural Organization of Target Site of PARP Inhibitors
2.2 Structural Organization of PARP Inhibitors


3. Therapeutic Exploitation of Role of PARP Proteins in Normal Cells & Cancer Cells
3.1 Significance of PARP Proteins in Normal Cells
3.2 Significance of PARP Proteins in Tumorgenesis: Affecting Cell Division & DNA
Repair
3.3 PARP Inhibitors: Distinct Modes of Action for Eliminating Cancer Cells


4. Global PARP Inhibitor Market Outlook
4.1 Current Market Scenario
4.2 Future Market Opportunity


5. PARP Inhibitor Market Opportunity by Region
5.1 US
5.2 Europe
5.3 China
5.4 Japan


6. Olaparib (Lynparza) – 1st Approved PARP Inhibitor; 2014
6.1 Overview
6.2 Patent Exclusivity
6.3 Pricing & Dosage
6.4 Sales Analysis


7. Rucaparib (Rubraca) – 2nd Approved PARP Inhibitor; 2016
7.1 Overview
7.2 Patent Exclusivity
7.3 Pricing & Dosage
7.4 Sales Analysis


8. Niraparib (Zejula) – 3rd Approved PAPR Inhibitor; 2017
8.1 Overview
8.2 Patent Exclusivity
8.3 Pricing & Dosage
8.4 Sales Analysis


9. Talazoparib (Talzenna) – 4th Approved PARP Inhibitor; 2018
9.1 Overview
9.2 Patent Exclusivity
9.3 Pricing & Dosage


10. Fuzuloparib (AiRuiYi) - 5th Approved PARP Inhibitor; 2020


11. Pamiparib (Partruvix) – 6th Approved PARP Inhibitor; 2021


12. PARP Inhibitors – Sales Forecast Till 2028
12.1 Lynparza
12.2 Rubraca
12.3 Zejula
12.4 Talzenna


13. Approved PARP Inhibitors Reimbursement Policy
13.1 Lynparza Reimbursement Policy
13.2 Rubraca Reimbursement Policy
13.3 Zejula Reimbursement Policy
13.4 Talzenna Reimbursement Policy


14. PARP Inhibitor Clinical Trial Insight
14.1 Company
14.2 Country
14.3 Indication
14.4 Indication


15. Global Poly(ADP-Ribose) Polymerase Inhibitors Clinical Trials By Company, Indication & Phase
15.1 Preclinical
15.2 Phase-I
15.3 Phase-I/II
15.4 Phase-II
15.5 Phase-II/III
15.6 Phase-III


16. Marketed Poly(ADP-Ribose) Polymerase Inhibitors Clinical insights


17. PARP Inhibitors with Conventional Cancer Therapy: Efficacy & Dosage Analysis
17.1 PARP Inhibitors with Chemotherapy
17.1.1 Temozolomide
17.1.2 Platinum Salts
17.1.3 Taxanes
17.1.4 Gemcitabine
17.1.5 Topoisomerase Iinhibitors
17.2 PARP Inhibitors in Combination with Radiotherapy


18. Improved Efficacy of PARP Inhibitors by Modern Cancer Therapies
18.1 Combination of PARP Inhibitors & Targeted Therapies
18.1.1 PARP Inhibitors with EGFR Inhibitors
18.1.2 PARP Inhibitors with VEGFR Inhibitors
18.1.3 PARP Inhibitors with PI3K/mTOR Inhibitors
18.1.4 PARP Inhibitors with Trastuzumab
18.1.5 Anti-endocrine agents
18.1.6 HSP90 Inhibitors
18.1.7 IGF-1R & HDAC Inhibitors
18.2 PARP Inhibitors in Combination with Immunotherapies


19. Global PARP Inhibitors Market Dynamics
19.1 Drivers
19.2 Market Challenges


20. PARP Inhibitor Market Future Perspective

21. Competitive Landscape
21.1 2X Oncology
21.2 Abott Laboratories
21.3 Allarity Therapeutics
21.4 AstraZeneca
21.5 BeiGene
21.6 Bristol Myers Squibb
21.7 Cephalon
21.8 Clovis Oncology
21.9 Eisai Co. Ltd
21.10 GlaxoSmithKline
21.11 IMPACT Therapeutics
21.12 Jeil Pharmaceuticals
21.13 KuDOS Pharmaceuticals
21.14 Kyowa Hakko Kirin
21.15 Lead Therapeutics
21.16 Ono Pharmaceutical
21.17 Pfizer