Table of Content

1. Introduction to CFTR Modulators
1.1 Overview
1.2 Evolution of CFTR Modulators


2. CFTR Modulators Mechanism of Action


3. Global CFTR Modulator Market Overview
3.1 Current Market Scenario
3.2 Future Market Potential of CFTR Modulators


4. US CFTR Modulator Market Overview
4.1 Current Market Scenario
4.2 Future Market Potential of CFTR Modulators


5. ROW CFTR Modulator Market Overview
5.1 Current Market Scenario
5.2 Future Market Potential of CFTR Modulators


6. Ivacaftor (Kalydeco) - Clinical & Commercial Insight
6.1 Overview
6.2 Patents & Assignees
6.3 Price & Dosage Insight
6.4 Sales Analysis


7. Ivacaftor/Lumacaftor (Orkambi) - Clinical & Commercial Insight
7.1 Overview
7.2 Patents & Assignees
7.3 Price & Dosage Insight
7.4 Sales Analysis


8. Tezacaftor/Ivacaftor (Symdeko) - Clinical & Commercial Insight
8.1 Overview
8.2 Patent & Assignees
8.3 Price & Dosage Insight
8.4 Sales


9. Elexacaftor/Ivacaftor/Tezacaftor (Trikafta) - Clinical & Commercial Insight
9.1 Overview
9.2 Patent & Assignees
9.3 Price & Dosage Insight
9.4 Global Sales


10. Global CFTR Modulators Vaccine Pipeline Overview
10.1 By Country
10.2 By Company
10.3 By Patient Segment
10.4 By Phase


11. Global CFTR Modulators Clinical Trials Insight
11.1 Research
11.2 Preclinical
11.3 Phase-I
11.4 Phase-I/II
11.5 Phase-II
11.6 Phase-III


12. Marketed CFTR Modulators Clinical Insights


13. CFTR Modulator Drugs Market Dynamics
13.1 Favorable Parameters
13.2 Market Restraints


14. CFTR Modulator Market Future Perspective


15. Competitive Landscape
15.1 Vertex Pharmaceuticals
15.2 Eloxx Pharma
15.3 ReCode Therapeutics
15.4 Arcturus Therapeutics
15.5 AbbVie
15.6 Spirovant Sciences
15.7 Translate Bio
15.8 ReAlta Life Sciences
15.9 Southern Research Institute
15.10 4D Molecular Therapeutics



List of Figures


Figure 1-1: Different Approaches for CFTR Modulators
Figure 1-2: Classes of CFTR Protein Mutations
Figure 1-3: History of CFTR Modulators

Figure 2-1: CFTR Modulators – Specific Target for Different Approaches

Figure 3-1: Global – CFTR Modulator Drugs Market Size (US$ Million), 2017-2020
Figure 3-2: Global – CFTR Modulator Drugs Market Size by Product (US$ Million), 2019 & 2020
Figure 3-3: Global – CFTR Modulator Drugs Market Size by Product (%), 2020
Figure 3-4: Global – CFTR Modulator Drugs Market Size by Product (%), 2019
Figure 3-5: Global – CFTR Modulator Drugs Market (US$ Billion), 2021-2026
Figure 3-6: Global – Cystic Fibrosis Incidence, 2020-2026

Figure 4-1: US – Incidence of Cystic Fibrosis, 2010-2020
Figure 4-2: Global – CFTR Modulator Market Size by Region (US$ Billion), 2020
Figure 4-3: Global – CFTR Modulator Market Size by Region (%), 2020
Figure 4-4: US – Expected CFTR Modulator Drugs Market Size (US$ Billion), 2021-2026
Figure 4-5: US – Cystic Fibrosis Incidence, 2021-2026

Figure 5-1: Global – CFTR Modulator Market Size by Region (US$ Billion), 2020
Figure 5-2: Global – CFTR Modulator Market Size by Region (%), 2020
Figure 5-3: ROW – Expected CFTR Modulator Drugs Market Size (US$ Billion), 2021-2026
Figure 5-4: ROW – Cystic Fibrosis Incidence, 2020-2026

Figure 6-1: US – Kalydeco FDA Approval History
Figure 6-2: Europe – Kalydeco FDA Approval History
Figure 6-3: US- Kalydeco FDA Approval & Patent Expiration Year
Figure 6-4: Europe - Kalydeco FDA Approval & Patent Expiration Year
Figure 6-5: US – Kalydeco Patent Approval & Expiration Year
Figure 6-6: US – Cost of Supply of 56 Oral Granule & Per Unit Cost of Kalydeco Oral Granule (US$), April’2021

Figure 6-7: US – Cost of Supply of 56 Oral Tablet & Per Unit Cost of 150mg Kalydeco Oral Tablet (US$), April’2021
Figure 6-8: US – Cost of Supply of 60 Oral Tablet & Per Unit Cost of 150mg Kalydeco Oral Tablet (US$), April’2021
Figure 6-9: Europe – Cost of Supply of 28 Oral Tablet & Per Unit Cost of 150mg Kalydeco Oral Tablet (Eur/US$), April’2021
Figure 6-10: Europe – Cost of Supply of 56 Oral Tablet & Per Unit Cost of 50mg, 75mg & 150mg Kalydeco Oral Tablet (Eur/US$), April’2021
Figure 6-11: UK – Cost of Supply of 56 Oral Granules & Per Unit Cost of 25mg, 50mg & 75mg Kalydeco Oral Granules (Eur/US$), April’2021
Figure 6-12: UK – Cost of Supply of 56 Oral Tablet & Per Unit Cost of 150mg Kalydeco Oral Tablet (Eur/US$), April’2021
Figure 6-13: UK – Cost of Supply of 28 Oral Tablet & Per Unit Cost of 150mg Kalydeco Oral Tablet (Eur/US$), April’2021
Figure 6-14: Kalydeco – Recommended Pediatric Dose of Oral Granules for Cystic Fibrosis by Weight (mg/12hrs)
Figure 6-15: Kalydeco – Maximum Recommended Pediatric Dose for Cystic Fibrosis by Type (mg/12hrs)
Figure 6-16: Global – Kalydeco Annual Sales (US$ Million), 2017-2020
Figure 6-17: Global – Kalydeco Quarterly Sales (US$ Million), 2020
Figure 6-18: Global – Kalydeco Quarterly Sales (US$ Million), 2019

Figure 7-1: US – Orkambi FDA Approval History by Age
Figure 7-2: Europe – Orkambi FDA Approval History by Age
Figure 7-3: US- Orkambi FDA Approval & Patent Expiration Year
Figure 7-4: Europe - Orkambi FDA Approval & Patent Expiration Year
Figure 7-5: US – Orkambi Patent Approval & Expiration Year
Figure 7-6: US - Cost of Supply of 56 Oral Granule & Per Unit Cost of Orkambi Oral Granule (US$), April’2021
Figure 7-7: US - Cost of Supply of 112 Oral Tablet & Per Unit Cost of Orkambi Oral Tablet (US$), April’2021
Figure 7-8: Europe - Cost of Supply of 112 Oral Tablet & Per Unit Cost of Orkambi Oral Tablet (Euro/US$), April’2021
Figure 7-9: UK- Cost of Supply of 112 Oral Tablet & Per Unit Cost of Orkambi Oral Tablet (Euro/US$), April’2021

Figure 7-10: UK- Cost of Supply of 56 Oral Granules & Per Unit Cost of Orkambi Oral Granule (Euro/US$), April’2021
Figure 7-11: Orkambi - Recommended Dose by Age (mg/day)
Figure 7-12: Global - Orkambi Annual Sales (US$ Million), 2017-2020
Figure 7-13: Global - Orkambi Quarterly Sales (US$ Million), 2020
Figure 7-14: Global - Orkambi Quarterly Sales (US$ Million), 2019

Figure 8-1: US - Symdeko FDA Approval History by Age
Figure 8-2: Europe - Symdevi EU Approval History by Age
Figure 8-3: Europe - Symdevi Approval & Patent Expiration Year
Figure 8-4: US - Symdeko Approval & Patent Expiration Year
Figure 8-5: US - Symdeko Patent Approval & Expiration Year
Figure 8-6: US - Cost of Supply of 56 Oral Tablet & Per Unit Cost of Symdeko Oral Tablet (US$), April’2021
Figure 8-7: Europe - Cost of Supply of 56 Oral Tablet & Per Unit Cost of Symdeko Oral Tablet (Euro/US$), April’2021
Figure 8-8: Europe - Cost of Supply of 28 Oral Tablet & Per Unit Cost of Symkevi Oral Tablet (Euro/US$), April’2021
Figure 8-9: Global - Symdeko/Symkevi Annual Sales (US$ Million), 2018-2020
Figure 8-10: Global - Symdeko/Symkevi Quarterly Sales (US$ Million), 2020
Figure 8-11: Global - Symdeko/Symkevi Quarterly Sales (US$ Million), 2019

Figure 9-1: US - Trikafta FDA Approval History by Mutation
Figure 9-2: Trikafta/Kaftrio - Initial Approval Year by Region
Figure 9-3: Europe - Kaftrio Approval & Patent Expiration Year
Figure 9-4: US - Trikafta Approval & Patent Expiration Year
Figure 9-5: US - Trikafta Patent Approval & Expiration Year
Figure 9-6: US - Cost of Supply of 84 Oral Tablet & Per Unit Cost of Trikafta Oral Tablet (US$), April’2021
Figure 9-7: Europe - Cost of Supply of 56 Oral Tablet & Per Unit Cost of Kaftrio Oral Tablet (Euro/US$), April’2021
Figure 9-8: UK - Cost of Supply of 56 Oral Tablet & Per Unit Cost of Kaftrio Oral Tablet (Euro/US$), April’2021
Figure 9-9: Trikafta/Kaftrio - Recommended Initial & Reduced Dose (mg/day)
Figure 9-10: Global - Trikafta/Kaftrio Annual Sales (US$ Million), 2019 & 2020
Figure 9-11: Global - Trikafta/Kaftrio Quarterly Sales (US$ Million), 2020

Figure 10-1: Global - CFTR Modulators in Clinical Pipeline by Country, 2021 till 2026
Figure 10-2: Global - CFTR Modulators in Clinical Pipeline by Company, 2021 till 2026
Figure 10-3: Global – CFTR Modulators in Clinical Pipeline by Patient Segment, 2021 till 2026
Figure 10-4: Global - CFTR Modulators in Clinical Pipeline by Phase, 2021 till 2026
Figure 13-1: CFTR Modulator Market Favorable Parameters
Figure 13-2: Global - CFTR Modulator Annual Sales by Product (US$ Million), 2020
Figure 13-3: US - CFTR Modulator Annual WAC by Product (US$)
Figure 13-4: Stages of Drug Development