Table of Content

i. Market Guides......................................................................................................................13
iA. Situation Analysis & COVID Update....................................................................................... 14
iB. Guide for Executives and Marketing Staff............................................................................. 15
iC. Guide for Investment Analysts and Management Consultants.......................................... 16
1. Introduction and Market Definition ...................................................................................17
1.1 What is Single Cell Genomics? .............................................................................................. 18
1.2 SCG – Still Early Days............................................................................................................... 20
1.3 Market Definition .................................................................................................................... 21
1.3.1 Market Size ........................................................................................................................ 21
1.3.2 Currency ........................................................................................................................... 21
1.3.3 Years .................................................................................................................................. 21
1.4 Methodology .......................................................................................................................... 22
1.4.1 Authors .............................................................................................................................. 22
1.4.2 Sources.............................................................................................................................. 22
1.5 Sizing the Genome – Not What You Think ............................................................................ 22
1.5.1 Cost, Price and Genome Size, Pricing Practice............................................................. 23
1.6 GLOBAL LISTING OF HIGH THROUGHPUT SEQUENCING ESTABLISHMENTS INSTALLED BASE – Location & Contacts.................................................................................................................... 24
2. Single Cell Genomics – Guide to Technology................................................................101
2.1 Isolating Single Cells ............................................................................................................. 102
2.1.1 FACS ................................................................................................................................ 104
2.1.2 LCM ................................................................................................................................. 107
2.1.3 Micromanipulators ......................................................................................................... 108
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2.1.4 Microfluidics .................................................................................................................... 108
2.2 Amplification......................................................................................................................... 109
2.2.1 WTA – Whole Transcriptome Amplification................................................................... 109
2.2.2 WGA – Whole Genome Amplification.......................................................................... 110
2.3 PCR ........................................................................................................................................ 110
2.4 NGS........................................................................................................................................ 111
2.5 Microarray............................................................................................................................. 112
2.6 Digital Spatial Profiling (DSP) Technology........................................................................... 112
3. Industry Overview .............................................................................................................114
3.1 Players in a Dynamic Market............................................................................................... 115
3.1.1 Academic Research Lab .............................................................................................. 115
3.1.2 Genomic Instrumentation Supplier ............................................................................... 116
3.1.3 Cell Separation and Viewing Instrumentation Supplier .............................................. 116
3.1.4 Cell Line and Reagent Supplier..................................................................................... 116
3.1.5 Pharmaceutical or Reagent Company ....................................................................... 116
3.1.6 Audit Body ...................................................................................................................... 117
3.1.7 Certification Body........................................................................................................... 117
4. Market Trends....................................................................................................................119
4.1 Factors Driving Growth......................................................................................................... 120
4.1.1 Immuno-oncology.......................................................................................................... 121
4.1.2 Research Range............................................................................................................. 122
4.1.3 Technology Maturity & Convergence.......................................................................... 122
4.1.4 Declining Costs ............................................................................................................... 123
4.2 Factors Limiting Growth........................................................................................................ 124
4.2.1 Competition.................................................................................................................... 124
4.2.2 Instrument Integration.................................................................................................... 124
4.2.3 Technology Shift ............................................................................................................. 125

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4.2.4 Technology Limitations................................................................................................... 125
4.3 Technology Development................................................................................................... 126
4.3.1 Spatial Profiling ............................................................................................................... 126
4.3.2 Integration....................................................................................................................... 126
4.3.3 Big Data .......................................................................................................................... 127
4.3.4 Kits and Commodities .................................................................................................... 127
5. Single Cell Genomics Recent Developments ................................................................128
5.1 Recent Developments – Importance and How to Use This Section................................. 129
5.1.1 Importance of These Developments ............................................................................ 129
5.1.2 How to Use This Section.................................................................................................. 129
Single-Cell COVID-19 Study Investigates Immune Hyperactivation....................................... 129
Levitas Bio to Launch Magnetic Levitation Cell Separation Platform.................................... 131
Single-Cell and Spatial Genomics ............................................................................................ 134
Single-Cell Genomics ................................................................................................................. 135
Namocell, Takara Bio, HepaTx Partner on Single-Cell Genomics........................................... 136
Vizgen Launches With $14M Series A Financing ...................................................................... 137
SeqWell Raises $9M in Series B Round....................................................................................... 137
MGI Tech Introduces Portable Sequencer, Single-Cell Prep Device ..................................... 138
Celsius Therapeutics to Use Single-Cell Platform in Immuno-Oncology................................. 140
10x Genomics Expects $271M In Proceeds.............................................................................. 141
Celsius Therapeutics, Janssen Biotech Form Biomarker Discovery Alliance .......................... 142
Bio-Rad, 10x Genomics Claim Single-Cell Patent Fight Victories on Different Fronts ............ 143
Bio-Rad Launches its Single Cell scATAC-Seq Solution............................................................ 145
10x Genomics Acquires Spatial Transcriptomics...................................................................... 146
Takara Bio strengthens its IP position on single cell RNA-seq .................................................. 147
Mission Bio Launches Tapestri® for Targeted Single-Cell DNA Custom Panels...................... 148
SingulOmics Detects Somatic Single Nucleotide Variations in Single Cells ........................... 150

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1CELLBIO and OMI to validate Single Cell Analysis for Personalized Medicine .................... 151
Sony MA900 Cell Sorter Nominated.......................................................................................... 154
UNC Cure Center and Cell Microsystems Receive NIH Contract for Single Cell HIV
Diagnostic Assay ........................................................................................................................ 155
Bio-Rad’s dd-PCR tests for leukemia cleared .......................................................................... 155
IncellDx's Single Cell Immuno-Oncology/PD-L1 Technology used in new Cancer Assay .... 156
Cytena GmbH land EUR 3M in Series A .................................................................................... 157
NanoString Announces Launch of CAR-T Panel ...................................................................... 158
Dolomite Bio launches high throughput single nuclei profiling on Nadia platform .............. 159
Silicon Biosystems Develops New Assay for Circulating Multiple Myeloma Cells .................. 160
6. Profiles of Key Single Cell Genomics Companies .........................................................162
10x Genomics ............................................................................................................................. 163
1CellBio........................................................................................................................................ 164
Agilent ......................................................................................................................................... 165
Beckman Coulter ....................................................................................................................... 167
Becton Dickinson........................................................................................................................ 168
Bio-Rad........................................................................................................................................ 170
Bruker........................................................................................................................................... 172
Cell Microsystems ....................................................................................................................... 174
Cellsee Diagnostics .................................................................................................................... 176
CellSorter ..................................................................................................................................... 177
Cytena ........................................................................................................................................ 178
CytoTrack.................................................................................................................................... 179
Dolomite Bio................................................................................................................................ 180
Fluidigm ....................................................................................................................................... 181
Fluxion Biosciences ..................................................................................................................... 182
Illumina ........................................................................................................................................ 183

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IncellDx........................................................................................................................................ 184
Labcyte ....................................................................................................................................... 185
Leica Microsystems .................................................................................................................... 186
Miltenyi Biotec............................................................................................................................. 187
Mission Bio ................................................................................................................................... 188
Oxford Nanopore Technologies................................................................................................ 189
NanoString .................................................................................................................................. 191
Perkin Elmer ................................................................................................................................. 193
Qiagen ........................................................................................................................................ 195
Readcoor .................................................................................................................................... 197
Silicon Biosystems........................................................................................................................ 200
Singulomics ................................................................................................................................. 202
Sony ............................................................................................................................................. 204
Takara Bio.................................................................................................................................... 205
Thermo Fisher .............................................................................................................................. 207
Watchmaker Genomics ............................................................................................................ 209
7. Single Cell Genomics Global Market Size.......................................................................210
7.1 Global Market Overview by Country.................................................................................. 211
7.1.1 Table – Global Market by Country................................................................................ 211
7.1.2 Chart – Global Market by Country ............................................................................... 212
7.2 Global Market Size by Technology - Overview.................................................................. 213
7.2.1 Table – Global Market by Technology ......................................................................... 213
7.2.2 Chart – Global Market by Technology – Base/Final Year Comparison ..................... 214
7.2.3 Chart – Global Market by Technology – Base Year .................................................... 215
7.2.4 Chart – Global Market by Technology – Final Year..................................................... 216
7.2.5 Chart – Global Market by Technology – Share by Year.............................................. 217
7.2.6 Chart – Global Market by Technology – Segment Growth ........................................ 218

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7.3 Global Market End User - Overview.................................................................................... 219
7.3.1 Table – Global Market End User .................................................................................... 219
7.3.2 Chart – Global Market End User – Base/Final Year Comparison ................................ 220
7.3.3 Chart – Global Market End User – Base Year ............................................................... 221
7.3.4 Chart – Global Market End User – Final Year................................................................ 222
7.3.5 Chart – Global Market End User – Share by Year ........................................................ 223
7.3.6 Chart – Global Market End User – Segment Growth................................................... 224
8. Global Market by Technology.........................................................................................225
8.1 PCR Market ........................................................................................................................... 226
8.1.1 Table - PCR Market by Country..................................................................................... 226
8.1.2 Chart - PCR Market by Country .................................................................................... 227
8.2 qPCR Market......................................................................................................................... 228
8.2.1 Table - qPCR Market by Country .................................................................................. 228
8.2.2 Chart - qPCR Market Growth ........................................................................................ 229
8.3 NGS Market........................................................................................................................... 230
8.3.1 Table – NGS Market by Country.................................................................................... 230
8.3.2 Chart – NGS Market Growth.......................................................................................... 231
8.4 Microarray Market................................................................................................................ 232
8.4.1 Table - Microarray Market by Country ......................................................................... 232
8.4.2 Chart - Microarray Market Growth ............................................................................... 233
8.5 Other Technology Market.................................................................................................... 234
8.5.1 Table - Other Technology Market by Country ............................................................. 234
8.5.2 Chart - Other Technology Market Growth ................................................................... 235
9. Single Cell Genomics Market by End User......................................................................236
9.1 Research Market .................................................................................................................. 237
9.1.1 Table - Research Market by Country............................................................................ 237
9.1.2 Chart - Research Market Growth.................................................................................. 238

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9.2 BioPharma Market................................................................................................................ 239
9.2.1 Table - BioPharma Market by Country ......................................................................... 239
9.2.2 Chart - BioPharma Market Growth ............................................................................... 240
9.3 Clinical Market...................................................................................................................... 241
9.3.1 Table - Clinical Market by Country ............................................................................... 241
9.3.2 Chart - Clinical Market Growth ..................................................................................... 242
9.4 Other End User Market ......................................................................................................... 243
9.4.1 Table - Other End User Market by Country................................................................... 243
9.4.2 Chart - Other End User Market Growth ........................................................................ 244
10. Appendices.....................................................................................................................245
10.1 FDA Cancer Drug Approvals by Year ............................................................................... 246
10.2 Clinical Trials Started 2010 to 2016..................................................................................... 247
10.3 Prevalence of Cancer Treatments.................................................................................... 248

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Table of Tables
Table 1 Global List of Gene Sequencing Facilities........................................................................ 25
Table 2 Cell Isolation Overview .................................................................................................... 104
Table 3 Market Players by Type ................................................................................................... 115
Table 4 Five Factors Driving Growth............................................................................................. 120
Table 5 Three Factors Limiting Growth ......................................................................................... 124
Table 6 Single Cell Genomics Global Market by Country/Region ............................................ 211
Table 7 Single Cell Genomics Global Market by Technology ................................................... 213
Table 8 Global Market End User ................................................................................................... 219
Table 9 PCR Market by Country ................................................................................................... 226
Table 10 qPCR Market by Country............................................................................................... 228
Table 11 NGS Market by Country................................................................................................. 230
Table 12 Microarray Market by Country ...................................................................................... 232
Table 13 Other Technology Market by Country.......................................................................... 234
Table 14 Research Market by Country ........................................................................................ 237
Table 15 BioPharma Market by Country...................................................................................... 239
Table 16 Clinical Market by Country............................................................................................ 241
Table 17 Other End User Market by Country ............................................................................... 243

Table of Figures
Figure 1 Size of Different Genomes ............................................................................................... 23
Figure 2 flourescence Activated Sorter ....................................................................................... 106

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Figure 3 Market Size by Country ................................................................................................... 212
Figure 4 Global Market by Technology - Base vs. Final Year ..................................................... 214
Figure 5 Technology Market Base Year ....................................................................................... 215
Figure 6 Technology Market Final Year........................................................................................ 216
Figure 7 Technology Share by Year ............................................................................................. 217
Figure 8 Technology Segment Growth ........................................................................................ 218
Figure 9 End User - Base vs. Final Year.......................................................................................... 220
Figure 10 End User Market Base Year ........................................................................................... 221
Figure 11 End User Market Final Year ........................................................................................... 222
Figure 12 End User Share by Year ................................................................................................. 223
Figure 13 End User Segment Growth............................................................................................ 224
Figure 14 Chart – PCR Market Growth ......................................................................................... 227
Figure 15 Chart qPCR Market Growth ......................................................................................... 229
Figure 16 Chart – NGS Market Growth......................................................................................... 231
Figure 17 Chart – Microarray Market Growth.............................................................................. 233
Figure 18 Chart – Other Technology Market Growth ................................................................. 235
Figure 19 Chart - Research Market Growth................................................................................. 238
Figure 20 Chart – BioPharma Market Growth.............................................................................. 240
Figure 21 Chart – Clinical Market Growth.................................................................................... 242
Figure 22 Chart – Other End User Market Growth ....................................................................... 244
Figure 23 FDA Cancer Drug Approvals by Year.......................................................................... 246
Figure 24 Clinical Trials for Immunotherapy by Year ................................................................... 247
Figure 25 Pie Chart of Prevalence of Cancer Treatments ......................................................... 248