Table of Content


List of Tables
List of Figures
Introduction
Global Markets Direct Report Coverage
Gamma Secretase (EC 3.4.23.) - Overview
Gamma Secretase (EC 3.4.23.) - Therapeutics Development
Products under Development by Stage of Development
Products under Development by Therapy Area
Products under Development by Indication
Products under Development by Companies
Products under Development by Universities/Institutes
Gamma Secretase (EC 3.4.23.) - Therapeutics Assessment
Assessment by Mechanism of Action
Assessment by Route of Administration
Assessment by Molecule Type
Gamma Secretase (EC 3.4.23.) - Companies Involved in Therapeutics Development
Adipo Therapeutics LLC
AlzeCure Pharma AB
Astellas Pharma Inc
Audion Therapeutics BV
Ayala Pharmaceuticals Inc
Eli Lilly and Co
Everfront Biotech Inc
Lipopharma Therapeutics SL
Merck & Co Inc
NeuroGenetic Pharmaceuticals Inc
Pharchoice Therapeutics Inc
Pipeline Therapeutics Inc
SpringWorks Therapeutics Inc
Takeda Pharmaceutical Co Ltd
Gamma Secretase (EC 3.4.23.) - Drug Profiles
ACD-679 - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
ACD-680 - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
AL-101 - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
AL-102 - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
crenigacestat - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
dibenzazepine - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
EF-005 - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
Gene Therapy to Activate PSEN1 for Heart Failure - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
GSI-34 - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
LP-226A1 - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
LY-3056480 - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
NGP-555 - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
nirogacestat hydrobromide - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
Peptides to Inhibit PSEN1 for Alzheimer’s Disease - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
PIPE-505 - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
Small Molecule 2 to Inhibit Gamma Secretase for Alzheimer’s Disease - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
Small Molecules to Inhibit Beta Secretase and Gamma Secretase for Alzheimer’s Disease - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
Small Molecules to Inhibit Gamma Secretase for Hearing Loss - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
Small Molecules to Inhibit PSEN1 for Alzheimer’s Disease - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
Small Molecules to Modulate Gamma Secretase for Alzheimer’s Disease - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
Gamma Secretase (EC 3.4.23.) - Dormant Products
Gamma Secretase (EC 3.4.23.) - Discontinued Products
Gamma Secretase (EC 3.4.23.) - Product Development Milestones
Featured News & Press Releases
Mar 18, 2020: SpringWorks Therapeutics announces issuance of new U.S. composition of matter patent to polymorphic form of Nirogacestat, extending patent protection into 2039
Mar 03, 2020: Ayala Pharmaceuticals granted U.S. FDA Fast Track Desigtion for AL101 for the treatment of recurrent or metastatic adenoid cystic carcinoma
Dec 09, 2019: Researchers present preclinical data showing synergistic activity of Springworks Therapeutics gamma secretase inhibitor (Nirogacestat) with glaxosmithkline’s BCMA antibody-drug conjugate (Belantamab Mafodotin) at the American Society of Hematology (ASH ) Annual Meeting
Sep 30, 2019: Ayala Pharmaceuticals presents encouraging prelimiry safety and efficacy data in patients with Recurrent/Metastatic Adenoid Cystic Carcinoma with progressing disease and notch activating mutations from ongoing phase 2 clinical trial at ESMO
Sep 26, 2019: SpringWorks receives orphan status for nirogacestat in Europe
Sep 19, 2019: Ayala Pharmaceuticals announces presentation at the European Society for Medical Oncology (ESMO)
Aug 30, 2019: SpringWorks receives breakthrough status for desmoid tumour drug
May 20, 2019: Ayala Pharmaceuticals to present at ASCO Annual Meeting on investigatiol drug AL101 in adenoid cystic carcinoma and triple negative breast cancer
May 20, 2019: SpringWorks Therapeutics announces initiation of Phase 3 trial (DeFi) of nirogacestat in adult patients with desmoid tumors
May 13, 2019: FDA grants Orphan Drug Desigtion to Ayala’s AL101 for potential treatment of adenoid cystic carcinoma (ACC)
Mar 07, 2019: New drug could restore hearing in the deaf
Mar 06, 2019: Ayala Pharmaceuticals to present preclinical data at AACR for AL101, a pan-notch inhibitor being evaluated for adenoid cystic carcinoma
Feb 05, 2019: Audion Therapeutics and REGAIN consortium announce positive phase I results in patients with sensorineural hearing loss
Dec 17, 2018: Ayala Pharmaceuticals announces first patient enrolled in phase 2 study of lead product candidate AL101 for Adenoid Cystic Carcinoma with notch activated mutations
Nov 07, 2018: SpringWorks Therapeutics receives FDA fast track desigtion for Nirogacestat for the treatment of adult patients with desmoid tumors
Appendix
Methodology
Coverage
Secondary Research
Primary Research
Expert Panel Validation
Contact Us
Disclaimer



List of Figures


Number of Products under Development by Stage of Development, H1 2020
Number of Products under Development by Therapy Areas, H1 2020
Number of Products under Development by Top 10 Indications, H1 2020
Number of Products by Mechanism of Actions, H1 2020
Number of Products by Stage and Mechanism of Actions, H1 2020
Number of Products by Routes of Administration, H1 2020
Number of Products by Stage and Routes of Administration, H1 2020
Number of Products by Molecule Types, H1 2020
Number of Products by Stage and Molecule Types, H1 2020


List of Tables


Number of Products under Development by Stage of Development, H1 2020
Number of Products under Development by Therapy Areas, H1 2020
Number of Products under Development by Indications, H1 2020
Number of Products under Development by Indications, H1 2020 (Contd..1), H1 2020
Number of Products under Development by Companies, H1 2020
Products under Development by Companies, H1 2020
Products under Development by Companies, H1 2020 (Contd..1), H1 2020
Products under Development by Companies, H1 2020 (Contd..2), H1 2020
Number of Products under Investigation by Universities/Institutes, H1 2020
Products under Investigation by Universities/Institutes, H1 2020
Number of Products by Stage and Mechanism of Actions, H1 2020
Number of Products by Stage and Route of Administration, H1 2020
Number of Products by Stage and Molecule Type, H1 2020
Pipeline by Adipo Therapeutics LLC, H1 2020
Pipeline by AlzeCure Pharma AB, H1 2020
Pipeline by Astellas Pharma Inc, H1 2020
Pipeline by Audion Therapeutics BV, H1 2020
Pipeline by Ayala Pharmaceuticals Inc, H1 2020
Pipeline by Eli Lilly and Co, H1 2020
Pipeline by Everfront Biotech Inc, H1 2020
Pipeline by Lipopharma Therapeutics SL, H1 2020
Pipeline by Merck & Co Inc, H1 2020
Pipeline by NeuroGenetic Pharmaceuticals Inc, H1 2020
Pipeline by Pharchoice Therapeutics Inc, H1 2020
Pipeline by Pipeline Therapeutics Inc, H1 2020
Pipeline by SpringWorks Therapeutics Inc, H1 2020
Pipeline by Takeda Pharmaceutical Co Ltd, H1 2020
Dormant Products, H1 2020
Dormant Products, H1 2020 (Contd..1), H1 2020
Dormant Products, H1 2020 (Contd..2), H1 2020
Discontinued Products, H1 2020