Table of Content

Chapter 1 Nothing Degrading about Saving Lives: E3 Ligands Recruiting New Drugs
Significance of Ubiquitin Proteasome System Discovery
Drug Discovery Approaches to Target E3 Ligases
Modulation of Protein-Protein Interactions
Allosteric Molecules
Screening Platforms
Targeted Protein Degradation and PROTACs- The Most Popular Trend of UPS Drug Discovery
Arvinas and Other "Rock Stars" Of UPS Drug Development Sector
Big Pharma Collaborations on TPD Platform
Importance Of TPD/Protacs Technology in Markets with Unmet Needs
Analyst’s Credential
Related BCC Research Reports
Chapter 2 Appendix: References



List of Figures


Figure 1 : Schematic Presentation of Ubiquitin-Proteasome System
Figure 2 : Annual Sales for Proteasome Inhibitors
Figure 3 : Schematic Presentation of PROTAC Platform
Figure 4 : Effect of PROTAC On Tau Levels in Hippocampus

 

List of Tables


Table 1 : Examples of Companies Using Targeted Protein Degradation Platform in Drug Discovery