Table of Content

1. Overview of Cell Therapy
1.1 Introduction to Cell Therapy
1.2 History & Evolution of Cell Therapy


2. Types of Cell Therapy
2.1 Allogeneic Cell Therapy
2.2 Autologous Cell Therapy
2.3 Human Embryonic Stem Cell Therapy
2.4 Neural Stem Cell Therapy
2.5 Mesenchymal Stem Cell Therapy
2.6 Hematopoietic Stem Cell Transplantation


3. Mechanism of Therapeutic Action in Cell Therapy


4. Manufacturing of Cell Therapies
4.1 Models for Manufacturing Cell Therapies
4.2 Facilities for Good Manufacturing Practice


5. Advantages of Cell Therapy Over Conventional Therapy
5.1 Anti-Aging with Cell Therapy
5.2 Addressing Other Diseases with Cell Therapy


6. Personalized Cell Therapy
6.1 Overview of Personalized Cell Therapy
6.2 Personalized Cell Therapy Using Epigenetic Tools
6.3 Personalized Cell Therapy through Mesenchymal Stem Cells
6.4 Treatment of Parkinson’s Disease through IPSCs
6.5 Case Study: Personalized Cell Therapy for Pulpitis Using Autologous Dental Pulp Stem Cells & Leukocyte Platelet Rich Fibrin



7. Cell Therapy Application by Therapeutic Areas
7.1 Cardiovascular Disease
7.2 Neurological Disorders
7.3 Inflammatory Diseases
7.4 Diabetes
7.5 Cancer


8. Global Cell Therapy Market Outlook
8.1 Current Market Scenario
8.2 Cell Therapy Market by Cell Source
8.2.1 Induced Pluripotent Stem Cell (IPSCs)
8.2.2 Bone Marrow
8.2.3 Umbilical Cord Blood Derived Cells
8.3 Global Cell Therapy Clinical Pipeline (Company,Indication, Region) Overview


9. US - Cell Therapy Dosage & Cost Analysis
9.1 Allocord
9.2 Laviv
9.3 Maci
9.4 Clevecord
9.5 Hemacord
9.6 Ducord
9.7 Provenge
9.8 HPC, Cord Blood (Clinimmune Labs, University of Colorado Cord Blood Bank)
9.9 HPC, Cord Blood (LifeSouth Community Blood Centers, Inc)
9.10 HPC, Cord Blood (Bloodworks)
9.11 HPC, Cord Blood (MD Anderson Cord Blood Bank)
9.12 Gintuit
9.13 Kymriah*
9.14 Yescarta*
9.15 Carticel


10. South Korea - Cell Therapy Dosage & Cost Analysis
10.1 Cartistem
10.2 Chondron
10.3 KeraHeal
10.4 Cellgram
10.5 Cure Skin Injection


11. Australia, Europe & Japan - Cell Therapy Dosage & Cost Analysis
11.1 Holoclar (Europe)
11.2 Yescarta (EU)
11.3 Kymriah (EU)
11.4 Temcell HS (Japan)
11.5 Chondrocytes-T-Ortho-ACI (Australia)


12. Cell Therapy Market Trends: Geographically
12.1 US
12.2 South Korea
12.3 Europe
12.4 Japan
12.5 China
12.6 Rest of the World
12.6.1 Africa
12.6.2 Middle East
12.6.3 South America


13. Advancements in Cell Therapy
13.1 Drug Based Therapies Advancements in Chronic Lymphocytic Leukemia
13.2 Advances in Cytomegalovirus Infection Prevention & Treatment
13.3 Stem Cell Therapy for the Treatment of Parkinson’s Disease
13.4 Stem Cell Therapy for the Treatment of Alzheimer’s Disease
13.5 Treatment of Rheumatoid Arthritis via Stem Cell Therapy
13.6 Role of Stem Cell Therapy in Treating Infertility
13.7 Stem Cells for Eye Diseases
13.8 Cell Therapy for Stroke and Angina Pectoris
13.9 Stem Cell Therapy in Improving Wrinkles & Acne Scars


14. Treg Cells – The Next Edge of Cell Therapy
14.1 Introduction to Treg Cell
14.2 Isolation & Expansion of Treg Cell
14.3 Mechanism of Action
14.4 Clinical Trials of Treg Cell Therapy
14.4.1 Adoptive Cell Therapy of Treg cells to Prevent GvHD
14.4.2 Adoptive Cell Therapy of Polyclonal & Alloantigen-specific Treg cells to Prevent Solid Organ Transplant Rejection
14.5 Treg Cell Therapy for the Treatmet of Autoinflammatory & Autoimmune Diseases
14.5.1 Inflammatory Bowel Disease
14.5.2 Systemic Lupus Erythematosus
14.5.3 Autoimmune Hepatitis
14.5.4 Pemphigus Vulgaris
14.5.5 Allergy and Asthma
14.6 Future Prospects of Treg Cell Therapy


15. Global Cell Therapy Market Dynamics
15.1 Market Drivers
15.2 Commercial Challenges


16. Global Cell Therapy Market Future Prospects


17. Marketed Cell Therapies Clinical Insight by Company & Indication
17.1 Tisagenlecleucel (Kymriah)
17.2 Axicabtagene Ciloleucel (Yescarta)
17.3 Allogeneic Cultured Keratinocytes And Fibroblasts (Gintuit)
17.4 Adipose Stem Cell Therapy (Adipocell (Anterogen), Cupistem & Queencell)
17.5 Tonogenchoncel-L (INVOSSA-K inj)
17.6 Mesenchymal Stem Cell Therapies (Stempeucel)
17.7 Remestemcel-L (Prochymal & TEMCELL HS Inj.)
17.8 Sipuleucel-T (Provenge)
17.9 Autologous Mesenchymal Stem Cell Therapy - Pharmicell
17.10 Autologous Cultured Chondrocytes (MACI)
17.11 Autologous Cultured Chondrocytes (Chondrotransplant DISC)
17.12 Autologous Corneal Epithelial Stem Cell Therapy (Holoclar)
17.13 Nalotimagene Carmaleucel (Zalmoxis)
17.14 Mesenchymal Stem Cell Therapy For Cartilage Repair (Cartistem)
17.15 Autologous Chondrocyte Implant - TETEC
17.16 Muscle-Derived Autologous Stem Cell Therapy (MyoCell)
17.17 Human Skin Replacement (CellSpray)
17.18 Leukocyte Cell Therapy (CureXcell)
17.19 Autologous Cultured Chondrocyte Implant (Carticel)
17.20 Azficel-T (Laviv)
17.21 Autologous Cultured Chondrocytes (CHONDRON)
17.22 Autologous Chondrocytes (BioCart)
17.23 Amniotic Cell Therapy (NuCel)
17.24 Dendritic Cell-Activated Cytokine-Induced Killer Cells - Shanghai Jia Fu Medical
17.25 Autologous Cultured Myoblasts And Fibroblasts (Urocell)


18. Global Cell Therapy Clinical Pipeline by Company, Indication & Phase
18.1 Research
18.2 Preclinical
18.3 Clinical
18.4 Phase-0
18.5 Phase-I
18.6 Phase-I/II
18.7 Phase-II
18.8 Phase-II/III
18.9 Phase-III
18.10 Preregistration
18.11 Registered


19. Competitive Landscape
19.1 Athersys Inc.
19.2 Baxter Healthcare Corporation
19.3 Bone Therapeutics
19.4 Celgene Corporation
19.5 Cell Medica
19.6 Cellerant Therapeutics
19.7 FibrocellScinence
19.8 Genzyme Corporation
19.9 Green Cross Cell
19.10 Histogenics Corporation
19.11 Intrexon Corporation
19.12 Intercytex
19.13 ISTO Biologics
19.14 Macrocure
19.15 Mesoblast
19.16 Molmed
19.17 Nuo Therapeutics Inc
19.18 OmniCyte
19.19 Opexa Therapeutics
19.20 Organogenesis
19.21 Pharmicell
19.22 TCA Cellular Therapy
19.23 Stem Cell Inc.
19.24 Teva Pharmaceuticals
19.25 Tigenix
19.26 Vericel Corporation



List of Figures


Figure 1-1: Cell Therapy Pathway
Figure 1-2: Evolution of Cell Therapy
Figure 2-1: Types of Cell Therapy
Figure 2-2: Steps in Allogeneic Cell Therapy
Figure 2-3: Steps in Autologous Cell Therapy
Figure 2-4: Steps in the Derivation of Human Embryonic Stem Cells
Figure 2-5: Cardinal Neural Stem Cell Properties
Figure 2-6: Mesenchymal Stem Cells Therapy Process
Figure 3-1: Cell Therapy Mechanism
Figure 4-1: Centralized Manufacturing Model
Figure 4-2: Near Patient Manufacturing Model
Figure 5-1: Major Steps in Cell Therapy
Figure 5-2: Global- Expected Aging Population of 60+ (Billion), 2015 & 2050
Figure 5-3: Advantages of Cell Therapy as a Rejuvenation Therapy
Figure 6-1: Advantages of Personalized Cell Therapy
Figure 6-2: Mesenchymal Stem Cells (MSCs) in Autism Spectrum Disorder (ASD) Treatment
Figure 6-3: Steps of iPSC Transplantation
Figure 7-1: Global - Mortality Caused by Non Communicable Disease (%), 2018
Figure 7-2: Cell Therapy for Cardiovascular Disease
Figure 7-3: Overview of Stem Cell Therapy in Cardiovascular Disease
Figure 7-4: Cell Therapy in Neurological Disorders
Figure 7-5: Cell Therapy in Treatment of Alzheimer’s disease
Figure 7-6: Cell Therapy in Diabetes
Figure 8-1: Cell Therapy- The Final Therapeutic Pillar of Healthcare
Figure 8-2: Global - Cell Therapy Market (US$ Billion), 2018 - 2026
Figure 8-3: Process for Conventional Drug Delivery
Figure 8-4: Process for Induced Pluripotent Stem Cell Based Drug Delivery
Figure 8-5: Global- Induced Pluripotent Stem Cell Therapy Market (US$ Million), 2018 - 2026
Figure 8-6: Steps involved in Bone Marrow Transplant
Figure 8-7: Global - Cell Therapies Clinical Pipeline by Phase (%), 2019 till 2026
Figure 8-8: Global - Cell Therapies Clinical Pipeline by Phase (Number), 2019 till 2026
Figure 8-9: Global - Cell Therapies Clinical Pipeline by Region (Number), 2019 till 2026
Figure 8-10: Global - Cell Therapies Clinical Pipeline by Region (Number), 2019 till 2026
Figure 8-11: Global - Cell Therapies Clinical Pipeline by Company (Number), 2019
Figure 8-12: Global - Cell Therapies Clinical Pipeline by Indication (Number), 2019
Figure 9-1: US – Allocord Infusion per Hour (Millilitres), Adult & Children
Figure 9-2: US – Laviv Average Injection Cost of Initial & Whole Session (US$), March’2019
Figure 9-3: US – Maci Cost Comparision over Mosaicplasty & Microfracture (US$)
Figure 9-4: US – Clevecord Dosage of Nucleated Cells per Killogram (Million) & Average Cost (US$)
Figure 9-5: US – Provenge Cost of Single Infusion vs Overall Cost (US$), July 2017
Figure 9-6: US – Kymriah Average Dosage of CAR positive viable T cells (Paediatric & Adults), August 2017
Figure 9-7: US – Kymriah Treatment Cost for Leukemia & Lymphomas (US$), July 2018
Figure 9-8: US – Yescarta Target Dose vs Maximum Dose of CAR-positive viable T cells, October 2017
Figure 9-9: US - Yescarta & Kymriah Overall Treatment Cost (US$), April 2018
Figure 9-10: US - Yescarta & Kymriah Estimated Payment Rate by Centers for Medicare and Medicaid Services (US$), April, 2018
Figure 9-11: US – Carticel Minimum & Maximum Cost (US$), October 2017
Figure 10-1: South Korea – Cartistem Dosage (Microlitres per cm2) & Cost (US$), October 2017
Figure 10-2: South Korea – Chondron Dosage (Millilitres per Vial) & Cost (US$), March 2019
Figure 10-3: South Korea - KeraHeal vs KeraHeal-Allo Dosage form (Miililitres Cell Suspension)
Figure 10-4: South Korea – Cellgram Dosage (Cells per 10 Millilitre) & Cost (US$), October 2017
Figure 11-1: Europe – Holoclar Minimum & Maximum Dosage (Cells per cm2) & Cost (US$), August’ 2017
Figure 11-2: European Union – Yescarta Dosage of CAR-positive viable T cells by Body Weight
Figure 11-3: European Union - Yescarta & Kymriah Treatment Cost for acute lymphoblastic leukaemia and diffuse large B-cell lymphoma (US$), August’ 2018
Figure 11-4: Japan - Temcell Dosage of Cells per Killogram Body Weight (Million)
Figure 11-5: Japan – Temcell Total Cost vs Cost per Bag (US$), October’ 2017
Figure 11-6: Australia - Ortho-ACI Constituents of Dulbecco’s Modified Eagle Medium (DMEM) nutrient mixture
Figure 11-7: Australia - Ortho-ACI Average Dose (Million Cells) & Cost of Treatment (US$)
Figure 12-1: Significance of Cell Therapy Market Technology
Figure 12-2: Drivers for Growth of Cell Therapy in Japan
Figure 12-3: Criteria Impacting Successful Cell Therapy
Figure 12-4: China Cell Therapy Market Strategy
Figure 12-5: Rest of the World – Cell Therapy Clinical Trial by Region (%), 2019
Figure 13-1: Signaling Pathway in Chronic Lymphocytic Leukemia
Figure 13-2: Advantages of Treating Rheumatoid arthritis with Umbilical Cord Mesenchymal Stem Cells
Figure 13-3: Stem Cell Therapy for the Treatment of Male Infertility
Figure 13-4: Cell Therapy for Ptients with Angina
Figure 13-5: Benefits of Stem Cell Therapy in Aesthetic Purposes
Figure 14-1: Working of CD4+ & CD25+ Regulatory T-Cell
Figure 14-2: Mechanism of Action of Treg Cell
Figure 14-3: Therapeutic Action of Treg Cell
Figure 14-4: Future Applications of Treg Cells
Figure 15-1: Global – Key Factors Driving the Cell Therapy Market
Figure 15-2: Global - Cell Therapy Market Challenges
Figure 16-1: Growth Opportunities for Cell Therapy
Figure 19-1: Bone Therapeutics Clinical Pipeline
Figure 19-2: Celgene Clinical Pipeline
Figure 19-3: Cell Medica Therapeutics Clinical Pipeline
Figure 19-4: Cellerant Therapeutics Clinical Pipeline
Figure 19-5: Fibrocell Science Clinical Pipeline
Figure 19-6: Intrexon Clinical Pipeline
Figure 19-7: Mesoblast Clinical Pipeline
Figure 19-8: Molmed Clinical Pipeline
Figure 19-9: Tigenix Clinical Pipeline
Figure 19-10: Vericel Corporation Clinical Pipeline

 

List of Tables


Table 2-1: Difference between Allogeneic & Autologous Cell Therapy
Table 5-1: Difference between Cell Therapy & Conventional Therapy
Table 13-1: Targeted Therapy in Patients with Chronic Lymphocytic Leukemia
Table 13-2: Targeted Therapy in Patients with Chronic Lymphocytic Leukemia
Table 13-3: Results of Phase I-II Trials of Adoptive Cell Therapy for Cytomegalovirus Infection in Allogeneic Hematopoietic Stem Cell Transplant
Table 14-1: Functions of Effector T-Cell & Treg Cell