1. Otsuka Holdings Co. Ltd.

2. Pfizer Inc.

3. Eli Lilly and Company

4. AstraZeneca plc.

5. Novartis AG

6. Bristol-Myers Squibb Company

7. GlaxoSmithKline plc.

8. Takeda Pharmaceutical Co. Ltd.

9. AbbVie Inc.

10. Johnson & Johnson