[184 Pages Report] The High-Throughput Screening Market size was estimated at USD 23.05 billion in 2023 and expected to reach USD 26.09 billion in 2024, at a CAGR 13.67% to reach USD 56.53 billion by 2030.

High throughput screening is a mode of scientific experimentation that comprises screening large compound libraries for activity against biological targets via automation, miniaturized assays, and large-scale data analysis. It involves the rapid testing and analysis of many samples, enabling researchers to evaluate various compounds’ effectiveness, selectivity, and potential toxicity. The primary applications of HTS are drug discovery and development in pharmaceutical and biotechnology companies, along with academic research laboratories. The rise in investment by governments and private organizations globally towards research and development activities fuels the growth of this market segment. Advances in computational biology enable researchers to analyze massive amounts of data generated by HTS systems more efficiently, which has significantly driven the market growth. However, high initial setup costs related to equipment procurement and maintenance and complexities related to data interpretation may hamper the market expansion. Expanding applications of HTS in different sectors, such as agrochemicals and environmental monitoring, will create a lucrative market opportunity in the forecasted period.

Product & Service: Proliferating use of software in the HTS process to manage vast amounts of raw data

Consumables are indispensable components of the HTS process, used in sample preparation and analysis to identify target compounds or biomolecules. Instruments used in HTS are essential for automating various aspects of the HTS workflow as they enable researchers to efficiently process large volumes of samples with minimal errors at rapid speeds. The services segment offers assay development, target validation, compound profiling, hit identification, and validation services tailored to client requirements. Softwares provide HTS workflows with robust solutions to manage vast raw data generated during experiments. Software solutions aid researchers in data acquisition, management, analysis, visualization, and reporting while ensuring compliance with regulatory guidelines.

Technology: Adoption of cell-based assay technologies to get biologically relevant data for the drug discovery process

Cell-based assays are vital for high-throughput screening that facilitates studying biological processes, drug discovery, and target identification. These assays employ living cells as test platforms to measure the efficacy or toxicity of compounds. 3D cell culture is a cost-effective screening platform for drug development and testing. The improved cell functionality and morphology of 3D cultures compared to 2D makes them a promising option for use in high throughput screening (HTS) and high content screening (HCS) applications. Scaffold-free techniques allow the cells to self-assemble to form non-adherent cell aggregates called spheroids. Spheroids mimic the solid tissues by secreting their extracellular matrix and displaying differential nutrient availability. Lab-on-a-chip technology integrates laboratory functions onto a single integrated circuit chip to enable rapid analysis with minimal sample volumes and reduced costs compared to traditional benchtop experiments. Label-free technology allows researchers to study biomolecular interactions without needing fluorescent or radioactive tags that can interfere with biological processes or produce false-positive results.

Screening Size: Utilization of 96-well format for increase in cell based studies

In high-throughput screening (HTS), various screening formats are utilized for diverse applications, such as drug discovery, biochemical assays, and cell-based assays. The 12-well format is suitable for conducting small-scale experiments that require larger volumes and more cells per well and is often utilized in cell culture studies and migration assays. The 1536-well format allows for the highest density of wells on a standard microplate footprint, enabling ultra-high-throughput screening (uHTS). This format is favored when working with limited sample volumes and expensive reagents due to the reduced well volume compared to other formats. Further, with a moderate number of wells and larger well size than higher-density formats, the 24-well format is ideal for primary cell culture experiments, organoid cultures, and studying larger organisms such as zebrafish embryos. The 384-well format is commonly used for medium- to high-throughput screening applications, such as compound profiling and high-content imaging. Additionally, the 384-well format balances sample volume and throughput, making it suitable for various assays. The 48-well format offers researchers increased throughput compared to the standard 6- or 12-well formats without sacrificing well size. This format is ideal for experiments requiring intermediate throughput levels or when transitioning from lower-density formats to higher-density ones. The 6-well format is widely used in basic research laboratories due to its large well size, which allows for easy handling and observation of cells under a microscope during various stages of cell culture. The 96-well format is a versatile and widely recognized standard for high-throughput screening applications. Its size makes it compatible with many liquid handling systems, making it suitable for various assays, such as ELISA, qPCR, and cell-based studies.

Application: Extensive utilization of the HTS process in drug discovery to identify compounds with pharmacological or biological activity

Biochemical screening uses a pure target protein of interest and estimates the binding of ligands or the inhibition of enzymatic action in vitro. These assays are typically performed in a competition structure where the compound under study must displace a known ligand or substrate. In the drug discovery process, HTS is used to identify small molecules that have the potential to modulate a target protein’s function, leading to therapeutic effects on disease-relevant pathways. These are starting points for medicinal chemical optimization during pharmacological probe or drug discovery and development. HTS technologies facilitate rapid data generation and analysis in life sciences research applications to uncover fundamental biological mechanisms or contribute to advancements in personalized medicine. Researchers use HTS for high-resolution imaging studies, gene expression profiling, or protein interaction analyses.

End User: Penetration of HTS technology in pharmaceutical & biotechnology companies for rapid development of novel therapeutics

Academic and research institutes typically require HTS systems for applications such as target identification, primary screening, and drug discovery and development. High throughput screening provides academic and research institutes the tools to accelerate their research, enhance productivity, and contribute significantly to the discoveries. Contract research organizations (CROs) used HTS to outsource drug discovery processes for pharmaceutical and biotechnology companies. CROs predominantly use HTS platforms for hit identification, lead optimization, and assay development projects. Pharmaceutical and biotechnology use HTS to focus on the rapid identification and development of novel therapeutic agents. These companies typically utilize HTS technology for lead generation, hit-to-lead optimization, and safety assessment studies. HTS is a critical tool that helps pharmaceutical and biotechnology companies streamline their research and development efforts, reduce costs, and bring new and innovative therapies to market more efficiently.

Regional Insights

The Americas experienced significant growth in high throughput screening market due to several government initiatives, patents for innovative technologies, and collaborative activities with industry partners to facilitate drug discovery through HTS. Within EU countries, HTS is being supported through initiatives funded by the European Commission research program towards advancing scientific breakthroughs and rising research and development activities by the key market vendors to optimize healthcare solutions. The Middle East and African region represents a growing market for HTS, driven mainly by investments in infrastructure development by governments seeking to improve local biotechnology capabilities. The Asia-Pacific region has observed a developing landscape due to government support by investing heavily in life sciences and pharmaceutical research and government-supported HTS advancement through funding programs such as the Japan Agency for Medical Research and Development (AMED). The rapidly growing pharmaceutical industry, fueled by strong government support in healthcare initiatives and innovation in drug discovery by providing access to HTS facilities at academic institutions, contributed to the market growth in the APAC region.

FPNV Positioning Matrix

The FPNV Positioning Matrix is pivotal in evaluating the High-Throughput Screening Market. It offers a comprehensive assessment of vendors, examining key metrics related to Business Strategy and Product Satisfaction. This in-depth analysis empowers users to make well-informed decisions aligned with their requirements. Based on the evaluation, the vendors are then categorized into four distinct quadrants representing varying levels of success: Forefront (F), Pathfinder (P), Niche (N), or Vital (V).

Market Share Analysis

The Market Share Analysis is a comprehensive tool that provides an insightful and in-depth examination of the current state of vendors in the High-Throughput Screening Market. By meticulously comparing and analyzing vendor contributions in terms of overall revenue, customer base, and other key metrics, we can offer companies a greater understanding of their performance and the challenges they face when competing for market share. Additionally, this analysis provides valuable insights into the competitive nature of the sector, including factors such as accumulation, fragmentation dominance, and amalgamation traits observed over the base year period studied. With this expanded level of detail, vendors can make more informed decisions and devise effective strategies to gain a competitive edge in the market.

Key Company Profiles

The report delves into recent significant developments in the High-Throughput Screening Market, highlighting leading vendors and their innovative profiles. These include Agilent Technologies, Inc., Aurora Biomed Inc., AXXAM S.p.A., Beckman Coulter, Inc., Bio-Rad Laboratories, Inc., BMG LABTECH GmbH, Charles River Laboratories International, Inc., Corning Incorporated, Danaher Corporation, DIANA Biotechnologies, a.s., Eurofins Scientific SE, F. Hoffmann-La Roche AG, Hamilton Company, IRBM S.p.A., Lonza Group AG, Luminex Corporation, Merck KGaA, Molecular Devices, LLC, NanoTemper Technologies GmbH, PerkinElmer, Inc., Promega Corporation, Reprocell Inc., SYGNATURE DISCOVERY LIMITED, Tecan Trading AG, and Thermo Fisher Scientific Inc..

Market Segmentation & Coverage

This research report categorizes the High-Throughput Screening Market to forecast the revenues and analyze trends in each of the following sub-markets:

  • Product & Service
    • Consumables
      • Laboratory Equipment
      • Reagents & Assay Kits
    • Instruments
      • Detection Systems
      • Liquid Handling Systems
    • Services
    • Software
  • Screening Size
    • 12-well Format
    • 1536-well Format
    • 24-well Format
    • 384-well Format
    • 48-well Format
    • 6-well Format
    • 96-well Format
  • Technology
    • Cell-Based Assays
      • 2D Cell Culture
      • 3D Cell Culture
        • Scaffold-Based Technology
          • Hydrogels
            • Alginate & Agarose
            • Animal-Derived Hydrogels
              • Collagen
              • Matrigel
            • Synthetic Hydrogels
          • Inert Matrix & Solid Scaffolds
          • Micropatterned Surfaces
        • Scaffold-Free Technology
          • Hanging-Drop Plates
          • Ultra-Low Binding Plates
      • Perfusion Cell Culture
      • Reporter-Based Assays
    • Lab-on-a-Chip Technology
    • Label-Free Technology
  • Application
    • Biochemical Screening
    • Drug Discovery
    • Life Sciences Research
  • End User
    • Academic & Research Institutes
    • Contract Research Organizations
    • Pharmaceutical & Biotechnology Companies

  • Region
    • Americas
      • Argentina
      • Brazil
      • Canada
      • Mexico
      • United States
        • California
        • Florida
        • Illinois
        • New York
        • Ohio
        • Pennsylvania
        • Texas
    • Asia-Pacific
      • Australia
      • China
      • India
      • Indonesia
      • Japan
      • Malaysia
      • Philippines
      • Singapore
      • South Korea
      • Taiwan
      • Thailand
      • Vietnam
    • Europe, Middle East & Africa
      • Denmark
      • Egypt
      • Finland
      • France
      • Germany
      • Israel
      • Italy
      • Netherlands
      • Nigeria
      • Norway
      • Poland
      • Qatar
      • Russia
      • Saudi Arabia
      • South Africa
      • Spain
      • Sweden
      • Switzerland
      • Turkey
      • United Arab Emirates
      • United Kingdom

The report offers valuable insights on the following aspects:

  1. Market Penetration: It presents comprehensive information on the market provided by key players.
  2. Market Development: It delves deep into lucrative emerging markets and analyzes the penetration across mature market segments.
  3. Market Diversification: It provides detailed information on new product launches, untapped geographic regions, recent developments, and investments.
  4. Competitive Assessment & Intelligence: It conducts an exhaustive assessment of market shares, strategies, products, certifications, regulatory approvals, patent landscape, and manufacturing capabilities of the leading players.
  5. Product Development & Innovation: It offers intelligent insights on future technologies, R&D activities, and breakthrough product developments.

The report addresses key questions such as:

  1. What is the market size and forecast of the High-Throughput Screening Market?
  2. Which products, segments, applications, and areas should one consider investing in over the forecast period in the High-Throughput Screening Market?
  3. What are the technology trends and regulatory frameworks in the High-Throughput Screening Market?
  4. What is the market share of the leading vendors in the High-Throughput Screening Market?
  5. Which modes and strategic moves are suitable for entering the High-Throughput Screening Market?