Introduction to Nucleic Acid Sample Preparation Market
The global nucleic acid sample preparation market is projected to reach $5,615.9 million by 2033 from $2,922.8 million in 2023, growing at a CAGR of 6.75% during the forecast period 2023-2033. The key factors driving the growth of the global nucleic acid sample preparation market include the growth in the number of genetic tests globally and an increase in demand for reliable next-generation sequencing (NGS) platforms in clinical laboratories.

Impact Analysis:

The nucleic acid sample preparation market has made an impact in the following ways:
Emergence of Advanced Stabilization Products: The rapid growth of genomic research has resulted in an increasing need for the storage of biologic samples, including DNA and RNA. Stabilization products enable researchers to transport and store biological samples for long periods with complete and rapid sample recovery at affordable costs. These products are used to retain biological materials at room temperature without degradation. These stabilization products ensure that the nucleic material, which has been carefully purified, remains safe and ready for further downstream applications, such as ensuring accurate gene expression analysis through qPCR or QRT-PCR. Research studies suggest that cell lysates created using lysis and stabilization buffers observed no shift in Ct value versus fresh samples, indicating that the nucleic acid was stable and intact while stored in these stabilization solutions.

Regulated vs. Multimodal Analysis: In order to cross-examine biological samples for changes in DNA and RNA efficiently, there have been considerable advances in NGS chemistries, platforms, and bioinformatics pipelines. Currently, the regulated approach requires the use of two separate workflows for library preparation from separate DNA and RNA isolates. The regulated analysis approach presents certain limitations, such as the large amounts of sample required for generating sufficient nucleic acid for multiple workflows, inefficient use of resources, and long turn-around times.

Nucleic Acid Sample Preparation Market Segmentation:

Segmentation 1: by Product

  • Consumables
  • Instruments



Consumables Segment to Continue Dominating the Nucleic Acid Sample Preparation Market (by Product)
Based on product, the nucleic acid sample preparation market has been led by consumables, which held a 67.83% share in 2022.

Segmentation 2: Consumables Market by Type

  • Kits
  • Reagents



Kits Segment to Continue Dominating the Nucleic Acid Sample Preparation Consumables Market by Type
Based on consumables market by type, the nucleic acid sample preparation market has been led by Kits, which held a 87.65% share in 2022.

Segmentation 3: Kits by Type

  • DNA/RNA Sample Isolation/Extraxtion/Purification
  • DNA/RNA Clean-Up and Concentration
  • DNA and RNA Quantification



DNA/RNA Sample Isolation/Extraxtion/Purification Segment to Continue Dominating the Nucleic Acid Sample Preparation Consumables Market Kits by Type
Based on nucleic acid sample preparation consumables market Kits by Type, the nucleic acid sample preparation market has been led by DNA/RNA Sample Isolation/Extraxtion/Purification, which held an 83.93% share in 2022.

Segmentation 4: Consumables Market by Analyte

  • DNA
  • RNA



DNA Segment to Continue Dominating the Nucleic Acid Sample Preparation Market (Consumables Market by Analyte)

Based on consumables market by analyte, the nucleic acid sample preparation market has been led by DNA, which held a 64.57% share in 2022.

Segmentation 5: by Technology

  • Consumable-Based Technology
    • Silica-Based
    • Magnetic Particle Technology
    • Other Technologies
  • Instrument-Based Technology
    • Automated Spin Column-Based
    • Magnetic Bead-Based
    • Automated Liquid Handling


Silica-Based Segment to Continue Dominating the Nucleic Acid Sample Preparation Consumable Market (by Consumable-Based Technology)

Based on consumable-based technology, the nucleic acid sample preparation consumable market has been led by silica-based technology, which held a 48.58% share in 2022.

Magnetic Bead-Based Segment to Continue Dominating the Nucleic Acid Sample Preparation Instrument Market (by Instrument-Based Technology)

Based on instrument-based technology, the nucleic acid sample preparation instrument market has been led by magnetic bead-based, which held a 58.72% share in 2022.

Segmentation 6: by Application

  • PCR
  • qPCR
  • NGS
  • Cloning
  • Microarray
  • Blotting Techniques
  • Other Applications



qPCR Segment to Hold its Dominance in the Nucleic Acid Sample Preparation Market (by Application)

Based on application, the nucleic acid sample preparation market has been led by qPCR, which held a 31.87% share in 2022.

Segmentation 7: by End User

  • Academic Research Institutes and Laboratories
  • Pharmaceutical and Biotechnology Companies
  • Contract Research Organizations (CROs)
  • Clinical Diagnostic Centers
  • Applied Testing (Forensic, Biobanks)



Academic Research Institutes and Laboratories Segment to Continue its Dominance in the Nucleic Acid Sample Preparation Market (by End User)

Based on end user, the nucleic acid sample preparation market has been led by academic research institutes and laboratories, which held a 45.95% share in 2022.

Segmentation 8: by Region

  • North America - U.S., Canada
  • Europe, Middle East and Africa (EMEA)
  • Asia-Pacific - China, Japan, and Rest-of-Asia-Pacific
  • Latin America (LATAM)



China dominated the Asia-Pacific nucleic acid sample preparation market in 2022. China has maintained itself as an attractive market for life sciences solution providers capable of tapping the strong demand for nucleic acid extraction products. Several companies, including Qiagen, Thermo Fisher Scientific, BioTeke, Promega, F. Hoffmann-La Roche AG, and Takara Bio, are the leading suppliers of nucleic acid extraction consumables in the country.

The Chinese government recognizes the potential of nucleic acid sample preparation and is actively promoting its development and manufacturing.

Recent Developments in the Nucleic Acid Sample Preparation Market

  • In November 2023, Qiagen N.V. introduced two groundbreaking additions to its sample technologies portfolio, i.e., the TissueLyser III that facilitates high-throughput disruption of diverse biological samples and the RNeasy PowerMax Soil Pro Kit that isolates high-purity RNA from challenging soil samples using advanced Inhibitor Removal Technology.
  • In July 2023, Qiagen announced the launch of the QIAseq Normalizer Kits that give researchers a fast, convenient, and cost-effective method to pool different DNA libraries for best-quality results from next-generation sequencing (NGS) runs.
  • In October 2023, PerkinElmer introduced the CHEF Magnetic Bead Cleanup System, providing automated nucleic acid purification through advanced magnetic bead technology. This novel system would help automate the nucleic acid purification process efficiently.
  • In May 2023, PerkinElmer (Revvity, Inc.) rebranded its diagnostics and life sciences business as Revvity. This strategic move marked a new identity and focus for the company’s ventures in these sectors.
  • In October 2022, PerkinElmer (Revvity, Inc.) and Element Biosciences, Inc. partnered to unveil innovative workflow solutions aimed at reducing the time and effort needed for the genomic analysis of samples, specifically leveraging the AVITI System, which is an emerging genomic sequencing platform.
  • In December 2023, Thermo Fisher Scientific Inc., the world leader in serving science, announced the launch of the Thermo Scientific KingFisher Apex Dx, an automated nucleic acid purification instrument, and Applied Biosystems MagMAX Dx Viral/Pathogen NA Isolation Kit for the isolation and purification of viral and bacterial pathogens from respiratory biological specimens.
  • In November 2023, Thermo Fisher Scientific unveiled the Ion Torrent Genexus System, providing high-throughput sequencing capabilities for a diverse range of NGS applications. This innovative system would cater to the demands of high-throughput NGS applications.
  • In August 2023, Zymo Research unveiled the Quick-DNA Microprep Kit, providing swift and high-purity genomic DNA isolation from diverse sample types. This newly introduced kit would address the need for rapid and efficient genomic DNA isolation.



Demand – Drivers and Limitations

Market Demand Drivers:
Growing Number of Genetic Tests: The growing adoption of genetic tests has ushered in a transformative era in healthcare, research, and personalized medicine. These tests, which encompass a wide range of applications, from diagnosing genetic disorders to uncovering ancestry information, have become increasingly popular among individuals and healthcare providers alike. As this adoption curve continues to climb, it will bring a significant rise and consistency in demand for nucleic acid sample preparation methods.

Increasing Demand for Reliable Next-Generation Sequencing (NGS) Platforms in Clinical Laboratories: The expanding utilization of next-generation sequencing (NGS) platforms within clinical laboratories is driving a substantial upswing in the demand for DNA/RNA sample preparation procedures. This increased demand can be primarily attributed to the critical role that NGS plays in advancing clinical diagnostics and personalized medicine. Moreover, NGS technologies have emerged as a crucial tool for revolutionizing the understanding of genomics and the molecular characteristics of various biological samples. It is gaining rapid acceptance in clinical practice due to its high throughput capabilities, allowing simultaneous analysis of numerous genes at both germline and somatic levels while using minimal starting material.

Increasing Prevalence of Infectious Diseases and Cancer Cases: The increasing prevalence of infectious diseases and cancer cases is driving a significant surge in the demand for nucleic acid sample preparation consumables and instruments. This growing demand is primarily due to the pivotal role that genetic analysis plays in the diagnosis, treatment, and monitoring of infectious diseases.

For instance, according to the International Agency for Research on Cancer (IARC), the global cancer burden was estimated at 24.3 million new cases in 2020, with a worldwide five-year prevalence estimated at 50.6 million.

Market Restraints:
High Cost of Automated Instruments: Nucleic acid isolation is one of the crucial steps in performing DNA and RNA extraction. Automation has been incorporated into nucleic acid isolation to ease the overall process of extraction and purification by reducing the time and errors associated with it. Although the price tag for various processes in which DNA extraction is applicable has been declining over the course of time, it has not reached a point where wide adoption in developing markets across the globe can be achieved. This high price tag is restricting the adoption of high-tech nucleic acid isolation platforms by hospitals/clinics, forensic centers, and academic/research institutes, among others, which are present in emerging markets all around the globe. Moreover, high capital investment is required to establish automated technology for sample preparation of genetic materials.

Rigid Regulatory Standards: Automated nucleic acid isolation has enhanced the overall nucleic acid sample preparation process by saving time, increasing throughput, and reducing human errors. As per the Food and Drug Administration (FDA), all test elements, such as software, reagents, consumables, and instrumentation, which are used in next-generation sequencing, should be well documented and specified. Additionally, it also states that the materials used for library preparation and laboratory equipment, such as automated liquid handlers, should also be well documented and specified. Moreover, with respect to the input and sample preparation, storage, processing, handling, and preservation should be well established and documented. There are some regulatory standards that are set by government regulatory bodies and need to be strictly followed while using automated sample preparation and nucleic acid isolation systems.

Market Opportunities:
Development and Utilization of More Biobanks in the Healthcare Segment: The healthcare industry is undergoing a transformative shift driven by advances in genomics, personalized medicine, and targeted therapies. The center of this evolution is the growing demand for DNA and RNA isolation, which is vital for understanding genetic underpinnings, diagnosing diseases, and developing tailored treatments. In this context, the development and utilization of more biobanks are indispensable, as they serve as the lifeblood of the nucleic acid sample preparation market, propelling healthcare forward. They provide a diverse range of genetic materials, enabling scientists to delve deep into the intricacies of human genetics. As more biobanks are established, the availability of genetic samples is amplified, thereby facilitating a deeper understanding of genetic variations and their impact on health.

Technological Advancements in DNA/RNA Sample Preparation Processes: Technological advancements in DNA/RNA sample preparation processes, including spin-column and automation in magnetic beads methods, have revolutionized molecular biology and genetics research. These innovations have made nucleic acid sample preparation more efficient, reliable, and scalable. For instance, technological advancements have led to the development of high-quality spin columns and membranes. These materials are designed to efficiently capture nucleic acids while removing impurities, ensuring pure and intact DNA/RNA samples.

How can this report add value to the Organization ?
Product/Innovation Strategy: The global nucleic acid sample preparation market has been extensively segmented based on various categories, such as product, technology, application, end user, and region. This can help readers get a clear overview of which segments account for the largest share and which ones are well-positioned to grow in the coming years.

Growth/Marketing Strategy: Product launches/product approvals accounted for the maximum number of key developments, i.e., nearly 66.04% of the total developments in the global nucleic acid sample preparation market were between January 2018 and December 2023.

Competitive Strategy: The global nucleic acid sample preparation market has numerous established players with product and service portfolios. Key players in the global nucleic acid sample preparation market analyzed and profiled in the study involve established players offering products and services of nucleic acid sample preparation.

Methodology

Key Considerations and Assumptions in Market Engineering and Validation

  • Detailed secondary research was performed to ensure maximum coverage of manufacturers/suppliers operational in a country.
  • Exact revenue information, up to a certain extent, was extracted for each company from secondary sources and databases. The revenues specific to the product, technology, application, end user, and region were then estimated for each market player based on fact-based proxy indicators as well as primary inputs.
  • The scope of this report has been carefully derived based on interactions with experts in different companies across the world. This report provides a market study of nucleic acid sample preparation.
  • The market contribution of the nucleic acid sample preparation anticipated to be launched in the future has been calculated based on historical analysis. This analysis has been supported by proxy factors such as the innovation scale of the companies, the status of funding, collaborations, customer base, and patent scenario.
  • The scope of availability of nucleic acid sample preparation in a particular region has been assessed based on a comprehensive analysis of companies’ prospects, regional end-user perception, and other factors impacting the launch of nucleic acid sample preparation in that region.
  • The base year considered for the calculation of the nucleic acid sample preparation market size is 2022. A historical year analysis has been done for the period FY2020-FY2021. The nucleic acid sample preparation market size has been estimated for FY2022 and projected for the period FY2023-FY2033.
  • Revenues of the companies have been referenced from their annual reports for FY2020- FY2022. For private companies, revenues have been estimated based on factors such as inputs obtained from primary research, funding history, product approval status, market collaborations, and operational history.
  • Regional distribution of the nucleic acid sample preparation market revenue has been estimated based on the companies in each region and the adoption rate of nucleic acid sample preparation. All the numbers have been adjusted to a single digit after the decimal for better presentation in the report. However, the real figures have been utilized for compound annual growth rate (CAGR) estimation. The CAGR has been calculated for the period 2023-2033.
  • The nucleic acid sample preparation market has been mapped based on the available nucleic acid sample preparation. All the key companies with significant offerings in this field have been considered and profiled in this report.
  • Nucleic acid sample preparation market strategies and developments of key players have been considered for the calculation of the potential of the nucleic acid sample preparation market in the forecast period.



Primary Research:
The primary sources involve industry experts in the nucleic acid sample preparation market, including the market players offering nucleic acid sample preparation solutions. Resources such as CXOs, vice presidents, product managers, directors, territory managers, and business development have been interviewed to obtain and verify both qualitative and quantitative aspects of nucleic acid sample preparation market research study.

The key data points taken from the primary sources include:

  • Validation and triangulation of all the numbers and graphs
  • Validation of the report’s segmentation and key qualitative findings for nucleic acid sample preparation
  • Understanding the competitive landscape and business model
  • Current and proposed production values of a product by market players
  • Validation of the numbers of the different segments of the market in focus
  • Percentage split of individual markets for regional analysis



Secondary Research

Open Sources

  • European Medicines Agency (EMA), American Chemical Society (ACS), Frontiers, World Health Organization (WHO), National Institute of Health (NIH), China Food and Drug Administration (CFDA), U.S. Food and Drug Administration (FDA), National Centre for Biotechnology Information (NCBI), and others
  • Annual reports, SEC filings, and investor presentations of the leading nucleic acid sample preparation market players
  • Company websites and detailed study of their portfolios
  • Gold standard magazines, journals, whitepapers, press releases, and news articles
  • Databases



The key data points taken from the secondary sources include:

  • Segmentation and percentage share estimates
  • Companies’ and countries’ understanding and data for nucleic acid sample preparation market value estimation.
  • Key industry/market trends of nucleic acid sample preparation market
  • Developments among top players of nucleic acid sample preparation market
  • Qualitative insights into various aspects of the nucleic acid sample preparation market, key trends, and emerging areas of innovation
  • Quantitative data for mathematical and statistical calculations



Key Market Players and Competition Synopsis
The companies profiled have been selected based on inputs gathered from primary experts and analyzing company coverage, type portfolio, and market penetration.

Some prominent names in the global nucleic acid sample preparation market include:

  • Agilent Technologies, Inc.
  • Autogen, Inc.
  • Bio-Rad Laboratories, Inc.
  • F. Hoffmann-La Roche AG
  • Merck KGaA
  • Macherey-Nagel GmbH & Co KG
  • New England Biolabs, Inc.
  • Norgen Biotek Corp.
  • Omega Bio-tek, Inc.
  • Revvity, Inc. (PerkinElmer, Inc.)
  • Promega Corporation
  • QIAGEN N.V.
  • Sage Science, Inc.
  • Tecan Group
  • Thermo Fisher Scientific Inc.
  • Zymo Research