Table of Content

Table of Contents
i. Market Guides.........................................13
iA. Situation Analysis & COVID Update.............................. 14
iB. Guide for Executives and Marketing Staf........................... 16
iC. Guide for Investment Analysts and Management Consultants............... 17
1. Introduction and Market Definiton.............................18
1.1 What is Single Cel Genomics? ................................ 19
1.2 SCG – Stil Early Days...................................... 21
1.3 Market Definiton ........................................ 2
1.3.1 Market Size......................................... 2
1.3.2 Curency .......................................... 2
1.3.3 Years............................................. 2
1.4 Methodology .......................................... 23
1.4.1 Authors ........................................... 23
1.4.2 Sources........................................... 23
1.5 Sizing the Genome – Not What You Think .......................... 23
1.5.1 Cost, Price and Genome Size, Pricing Practice..................... 24
1.6 GLOBAL LISTING OF HIGH THROUGHPUT SEQUENCING ESTABLISHMENTS INSTALED BASE –
Location & Contacts........................................ 25
2. Single Cel Genomics – Guide to Technology......................102
2.1 Isolating Single Cels ...................................... 103
2.1.1 FACS ............................................ 105
2.1.2 LCM ............................................. 108
2.1.3 Micromanipulators .................................... 109
2.1.4 Microfluidics........................................ 109
2.2 Amplifcation.......................................... 10
2.2.1 WTA – Whole Transcriptome Amplifcation....................... 10
2.2.2 WGA – Whole Genome Amplifcation.......................... 11
2.3 PCR ............................................... 11
2.4 NGS............................................... 12
2.5 Microaray........................................... 13
2.6 Digital Spatial Profilng (DSP) Technology.......................... 13
3. Industry Overview ......................................15
3.1 Players in a Dynamic Market................................. 16
3.1.1 Academic Research Lab ................................ 16
3.1.2 Genomic Instrumentation Supplier ........................... 17
3.1.3 Cel Separation and Viewing Instrumentation Supplier ................ 17
3.1.4 Cel Line and Reagent Supplier............................. 17
3.1.5 Pharmaceutical or Reagent Company ......................... 17
3.1.6 Audit Body ......................................... 18
3.1.7 Certifcation Body..................................... 18
4. Market Trends........................................120
4.1 Factors Driving Growth.................................... 121
4.1.1 Immuno-oncology..................................... 12
4.1.2 Research Range...................................... 123
4.1.3 Technology Maturity & Convergence.......................... 123
4.1.4 Declining Costs...................................... 124
4.2 Factors Limitng Growth.................................... 125
4.2.1 Competion........................................ 125
4.2.2 Instrument Integration................................... 125
4.2.3 Technology Shift ...................................... 126
4.2.4 Technology Limitations.................................. 126
4.3 Technology Development.................................. 127
4.3.1 Spatial Profilng ...................................... 127
4.3.2 Integration......................................... 127
4.3.3 Big Data .......................................... 128
4.3.4 Kits and Commodites................................... 128
5. Single Cel Genomics Recent Developments ......................129
5.1 Recent Developments – Importance and How to Use This Section............ 130
5.1.1 Importance of These Developments.......................... 130
5.1.2 How to Use This Section.................................. 130
Parse Biosciences Lowers Cost Bariers to Single-Cel Transcriptomics............ 130
Deepcel Advancing Tech for Single-Cel Genomics..................... 13
10x Genomics Outlines 2021 Growth Plans ........................... 137
Single-Cel Genomics Firm Analytical Biosciences Inks Deal with BioMap .......... 139
IsoPlexis Features Cheaper, More Flexible Single-Cel Proteomic Systems .......... 139
DNTR-Seq Combines WGS, Transcriptomics in Single Cels .................. 142
BitBiome Builds Single-Cel Bacterial Sequencing Busines................... 145
S2 Genomics Signs Distribution Agreements for Asia-Pacifc................. 147
Single-Cel COVID-19 Study Investigates Immune Hyperactivation.............. 148
Levitas Bio to Launch Magnetic Levitation Cel Separation Platform............. 150
Single-Cel and Spatial Genomics ................................ 153
Single-Cel Genomics....................................... 154
Namocel, Takara Bio, HepaTx Partner on Single-Cel Genomics............... 15
Vizgen Launches With $14M Series A Financing ........................ 156
SeqWel Raises $9M in Series B Round.............................. 156
MGI Tech Introduces Portable Sequencer, Single-Cel Prep Device ............. 157
Celsius Therapeutics to Use Single-Cel Platform in Immuno-Oncology............ 159
10x Genomics Expects $271M In Proceeds........................... 160
Celsius Therapeutics, Jansen Biotech Form Biomarker Discovery Aliance ......... 161
Bio-Rad, 10x Genomics Claim Single-Cel Patent Fight Victories on Diferent Fronts.... 162
Bio-Rad Launches its Single Cel scATAC-Seq Solution..................... 164
10x Genomics Acquires Spatial Transcriptomics........................ 165
Takara Bio strengthens its IP positon on single cel RNA-seq ................. 16
Mision Bio Launches Tapestri® for Targeted Single-Cel DNA Custom Panels........ 167
SingulOmics Detects Somatic Single Nucleotide Variations in Single Cels......... 169
1CELBIO and OMI to validate Single Cel Analysis for Personalized Medicine ....... 170
Sony MA90 Cel Sorter Nominated............................... 173
UNC Cure Center and Cel Microsystems Receive NIH Contract for Single Cel HIV
Diagnostic Asay ......................................... 174
Bio-Rad’s dd-PCR tests for leukemia cleared .......................... 174
IncelDx's Single Cel Immuno-Oncology/PD-L1 Technology used in new Cancer Asay .. 175
Cytena GmbH land EUR 3M in Series A ............................. 176
NanoString Announces Launch of CAR-T Panel ........................ 17
Dolomite Bio launches high throughput single nuclei profilng on Nadia platform ..... 178
Silcon Biosystems Develops New Asay for Circulating Multiple Myeloma Cels...... 179
6. Profiles of Key Single Cel Genomics Companies ....................181
10x Genomics........................................... 182
1CelBio............................................... 183
Agilent ............................................... 184
Beckman Coulter ......................................... 186
Becton Dickinson......................................... 187
Bio-Rad............................................... 189
Bitbiome .............................................. 191
Bruker................................................ 192
Cel Microsystems ......................................... 194
Celsee Diagnostics........................................ 196
CelSorter.............................................. 197
Cytena ............................................... 198
CytoTrack.............................................. 19
Dolomite Bio............................................ 20
Fluidigm ............................................... 201
Fluxion Biosciences........................................ 202
Ilumina ............................................... 203
IncelDx............................................... 204
Labcyte............................................... 205
Leica Microsystems ........................................ 206
Miltenyi Biotec........................................... 207
Mision Bio ............................................. 208
Oxford Nanopore Technologies................................. 209
NanoString ............................................. 21
Perkin Elmer............................................. 213
Qiagen ............................................... 215
Readcoor.............................................. 217
S2 Genomics............................................ 20
Silcon Biosystems......................................... 21
Singulomics ............................................. 23
Sony ................................................. 25
Takara Bio.............................................. 26
Thermo Fisher ........................................... 28
Watchmaker Genomics ..................................... 230
7. Single Cel Genomics Global Market Size.........................231
7.1 Global Market Overview by Country............................ 232
7.1.1 Table – Global Market by Country............................ 232
7.1.2 Chart – Global Market by Country ........................... 23
7.2 Global Market Size by Technology - Overview....................... 234
7.2.1 Table – Global Market by Technology ......................... 234
7.2.2 Chart – Global Market by Technology – Base/Final Year Comparison ....... 235
7.2.3 Chart – Global Market by Technology – Base Year .................. 236
7.2.4 Chart – Global Market by Technology – Final Year.................. 237
7.2.5 Chart – Global Market by Technology – Share by Year................ 238
7.2.6 Chart – Global Market by Technology – Segment Growth .............. 239
7.3 Global Market End User - Overview............................. 240
7.3.1 Table – Global Market End User ............................. 240
7.3.2 Chart – Global Market End User – Base/Final Year Comparison ........... 241
7.3.3 Chart – Global Market End User – Base Year ...................... 242
7.3.4 Chart – Global Market End User – Final Year...................... 243
7.3.5 Chart – Global Market End User – Share by Year ................... 24
7.3.6 Chart – Global Market End User – Segment Growth.................. 245
8. Global Market by Technology...............................246
8.1 PCR Market .......................................... 247
8.1.1 Table - PCR Market by Country............................. 247
8.1.2 Chart - PCR Market by Country ............................. 248
8.2 qPCR Market.......................................... 249
8.2.1 Table - qPCR Market by Country ............................ 249
8.2.2 Chart - qPCR Market Growth .............................. 250
8.3 NGS Market.......................................... 251
8.3.1 Table – NGS Market by Country............................. 251
8.3.2 Chart – NGS Market Growth............................... 252
8.4 Microaray Market....................................... 253
8.4.1 Table - Microaray Market by Country ......................... 253
8.4.2 Chart - Microaray Market Growth ........................... 254
8.5 Other Technology Market................................... 25
8.5.1 Table - Other Technology Market by Country ..................... 25
8.5.2 Chart - Other Technology Market Growth....................... 256
9. Single Cel Genomics Market by End User........................257
9.1 Research Market ....................................... 258
9.1.1 Table - Research Market by Country.......................... 258
9.1.2 Chart - Research Market Growth............................ 259
9.2 BioPharma Market....................................... 260
9.2.1 Table - BioPharma Market by Country ......................... 260
9.2.2 Chart - BioPharma Market Growth ........................... 261
9.3 Clinical Market......................................... 262
9.3.1 Table - Clinical Market by Country ........................... 262
9.3.2 Chart - Clinical Market Growth ............................. 263
9.4 Other End User Market .................................... 264
9.4.1 Table - Other End User Market by Country....................... 264
9.4.2 Chart - Other End User Market Growth ......................... 265
10. Appendices........................................26
10.1 FDA Cancer Drug Approvals by Year........................... 267
10.2 Clinical Trials Started 2010 to 2016............................. 268
10.3 Prevalence of Cancer Treatments............................. 269


 

Table of Tables
Table 1 Global List of Gene Sequencing Facilties......................... 26
Table 2 Cel Isolation Overview ................................... 105
Table 3 Market Players by Type.................................. 16
Table 4 Five Factors Driving Growth................................ 121
Table 5 Three Factors Limitng Growth ............................... 125
Table 6 Single Cel Genomics Global Market by Country/Region ............... 232
Table 7 Single Cel Genomics Global Market by Technology .................. 234
Table 8 Global Market End User .................................. 240
Table 9 PCR Market by Country .................................. 247
Table 10 qPCR Market by Country................................. 249
Table 1 NGS Market by Country .................................. 251
Table 12 Microaray Market by Country .............................. 253
Table 13 Other Technology Market by Country.......................... 25
Table 14 Research Market by Country .............................. 258
Table 15 BioPharma Market by Country.............................. 260
Table 16 Clinical Market by Country................................ 262
Table 17 Other End User Market by Country ........................... 264

Table of Figures
Figure 1 Size of Diferent Genomes ................................. 24
Figure 2 flourescence Activated Sorter .............................. 107
Figure 3 Market Size by Country .................................. 23
Figure 4 Global Market by Technology - Base vs. Final Year .................. 235
Figure 5 Technology Market Base Year .............................. 236
Figure 6 Technology Market Final Year.............................. 237
Figure 7 Technology Share by Year ................................ 238
Figure 8 Technology Segment Growth .............................. 239
Figure 9 End User - Base vs. Final Year............................... 241
Figure 10 End User Market Base Year............................... 242
Figure 1 End User Market Final Year ............................... 243
Figure 12 End User Share by Year .................................. 24
Figure 13 End User Segment Growth................................ 245
Figure 14 Chart – PCR Market Growth ............................... 248
Figure 15 Chart qPCR Market Growth ............................... 250
Figure 16 Chart – NGS Market Growth............................... 252
Figure 17 Chart – Microaray Market Growth........................... 254
Figure 18 Chart – Other Technology Market Growth ....................... 256
Figure 19 Chart - Research Market Growth............................ 259
Figure 20 Chart – BioPharma Market Growth........................... 261
Figure 21 Chart – Clinical Market Growth............................. 263
Figure 2 Chart – Other End User Market Growth......................... 265
Figure 23 FDA Cancer Drug Approvals by Year.......................... 267
Figure 24 Clinical Trials for Immunotherapy by Year ....................... 268
Figure 25 Pie Chart of Prevalence of Cancer Treatments .................... 269