Oligonucleotide Synthesis Market by Product and Service (Synthesizer, Custom Oligonucleotide Synthesis Service, Probes, Primers, Linkers and Adaptor, Reagents), Application (Research, Therapeutics, Diagnostics), and End User - Forecast to 2025
The global oligonucleotide synthesis market is expected to grow at a CAGR of 10.4% from 2019 to 2025 to reach $3.9 billion by 2025. The growth in oligonucleotide synthesis market is mainly attributed to the growing adoption of synthesized oligonucleotides in diagnostic and clinical applications, rising R&D expenditure and investment by government organizations and pharmaceutical and biotechnology companies, plummeting cost of sequencing, increasing public and private spending on genomics, and rising venture capital investments/funding. However, factors such as lack of regulations for therapeutic oligos and price erosion of synthesized oligonucleotides are likely to hinder the market growth. On the other hand, large scale synthesis of oligonucleotides and delivery of oligonucleotide drugs to specific target are recognized as the major hurdles to overcome.

The overall oligonucleotide synthesis market is primarily segmented by product & services [synthesized oligonucleotide (primers, probes, and linkers & adapters), oligonucleotide synthesis product (reagents & consumables, equipment), custom oligonucleotide synthesis services (Intermediate scale, large scale, and small scale oligonucleotides)], application [research (PCR, qPCR/RTqPCR, sequencing, genes synthesis, and, other research applications), diagnostics, therapeutics (RNAi oligonucleotide-based therapies, DNA/antisense oligonucleotide-based therapies, immunotherapy {CpG oligonucleotide-based therapies}, and nucleic acid aptamers), end user (pharmaceutical and biotechnology companies, academic research institutes, diagnostic laboratories, and others), and geography.

In 2019, oligonucleotide synthesis products segment is estimated to account for the largest share of the global oligonucleotide synthesis market. The large share of oligonucleotide synthesis products is mainly attributed to the wide use of synthesizers and consumables like PCR primers in PCR studies. The huge adoption of PCR technologies across research and diagnostic fields owing to their ease of use, high sensitivity, and cost effectiveness have attributed to the large share of the oligonucleotide synthesis products market.

On the basis of application, research applications segment accounted for the largest share of the overall oligonucleotide synthesis market in 2019. The major share of the research applications segment is mainly attributed to the rising adoption of oligonucleotides in drug discovery and development with the recent development in the gene synthesis and next generation sequencing areas. However, the use of oligonucleotides for diagnostic applications is likely to grow at the fastest CAGR during the forecast period. This is mainly due to developing applications of molecular diagnostics (MDx) and genetic testing.

An in-depth analysis of the geographical scenario of the oligonucleotide synthesis market provides detailed qualitative and quantitative insights about the five major geographies (North America, Europe, Asia-Pacific, Latin America, and the Middle East & Africa) along with the coverage of major countries in each region. North America commanded the largest share of the global oligonucleotide synthesis market in 2019, followed by Europe, Asia-Pacific, Latin America, and the Middle East & Africa.

The key players operating in the global oligonucleotide synthesis market are Integrated DNA Technologies, Inc. (U.S.) (Part of Danaher Corporation), Merck KGaA (Germany), Eurofins Scientific SE (Luxembourg), Thermo Fisher Scientific Inc. (U.S.), Agilent Technologies, Inc. (U.S.), GE Healthcare (U.S.), GeneDesign, Inc. (Japan) (Part of Ajinomoto Co., Inc.), Kaneka Eurogentec (Belgium) (Part of Kaneka Corporation), LGC Biosearch Technologies (U.S.), Bio-synthesis Inc. (U.S.), TriLink BioTechnologies, LLC (U.S.) (Part of Maravai LifeSciences), and ATDBio Ltd. (U.K.), among others.

Scope of the Report:

Oligonucleotide Synthesis Market, by Product & Services
  • Oligonucleotide Synthesis Products
  • ·Oligonucleotide Synthesis Equipment (Synthesizers)
  • ·Oligonucleotide Synthesis Reagents & Consumables
  • Synthesized Oligonucleotides (Pre-Designed Oligonucleotides)
  • ·Primers
  • ·Probes
  • ·Linkers & Adaptors
  • Custom Oligonucleotide Synthesis Services (Custom Oligonucleotides)
  • ·Large-Scale Oligonucleotide Synthesis
  • ·Intermediate-Scale Oligonucleotide Synthesis
  • ·Small-Scale Oligonucleotide Synthesis

Oligonucleotide Synthesis Market, by Application

  • Research
  • ·PCR
  • ·qPCR/RTqPCR
  • ·Sequencing
  • ·Gene Synthesis
  • ·Other Research Applications
  • Diagnostics
  • Therapeutics
  • ·RNAi Oligonucleotide-based Therapies
  • ·DNA/Antisense Oligonucleotide-based Therapies
  • ·Immunotherapy (CpG Oligonucleotide-based Therapies)
  • ·Nucleic Acid Aptamers

Oligonucleotide Synthesis Market, by End User

  • Pharmaceutical and Biotechnology Companies
  • Academic Research Institutes
  • Diagnostic Laboratories
  • Others

Oligonucleotide Synthesis Market, by Geography

  • North America
  • U.S.
  • Canada
  • Europe
  • Germany
  • France
  • U.K.
  • Italy
  • Spain
  • Rest of Europe (RoE)
  • Asia-Pacific (APAC)
  • Japan
  • China
  • India
  • Rest of Asia-Pacific (RoAPAC)
  • Latin America
  • Middle East & Africa