The global market for Cell-Based Assays is projected to reach US$28.3 billion by the year 2024, driven by growing investments in new drug discovery projects; rising number of drug targets screened through genomics and proteomics; and robust demand for cell based therapies, small molecule drugs and biotherapeutics. Advantages of cell-based high-volume screening during drug discovery include timely identification of cell receptors that trigger adverse drug effects and drug-drug interactions (DDIs); reduced risk of late stage drug failures due to cytotoxicity issues; easy identification of complications associated with drug metabolism; better understanding of drug compounds and their interactions with cells and thereby better ability to enable researchers to modify chemical compound structures to develop more safer therapeutic agents; and lower drug development costs by effective elimination of expensive errors. By virtue of the advantages offered, especially reduced compound attrition in the late stages, cell-based assays are increasingly being used for lead profiling and for validating drug targets. The market will continue to benefit from continuous technology advancements aimed at managing the complexity of understanding the biology of living organisms and disease processes. 3D cell based assays are growing in prominence against the backdrop of growing acceptance of 3-D cell culture for its ability to more closely mimic the in-vivo extracellular environment. The market is therefore ripe for high fidelity, high value 3D cell-based assays tailored for drug discovery applications. The United States represents the single largest market worldwide, followed by Europe. Developing regions, including Asia-Pacific, Latin America, and the Middle East & Africa, are expected to emerge as fast growing markets supported by growing expenditure on R&D and a parallel increase in opportunity in pharma and academic applications.  

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Company and Industry News & Stories
  • BioIVT Takes Over Ascendance Biotechnology in a Move to Expand the Former’s Drug Safety Testing & Toxicology Portfolios
  • Agilent Acquires Luxcel Biosciences, a Developer of Real-Time Fluorescence Plate-Reader Based In Vitro Cell Assay Kits
  • Eurofins Completes the Acquisition of DiscoverX in a Bid to Strengthen Presence in Drug Discovery and Development Market
  • IntelliCyt Introduces Cy-Clone Plus Assay System for Ranking & Selection of Clones for Cell Line Development Using the iQue Screener PLUS Platform

Outlook in Key Market Segments
  • Through 2024, Drug Discovery will remain the largest end-use market, followed by ADME Testing.
  • ADME Testing end-use is projected to witness the fastest growth driven by enhanced accuracy and predictability in the synthesis of a large number of new molecules.

Product Definition & Scope
  • Cell-based assays are experiments conducted on live cells, and comprise of various types of assays for the quantification of cell morphology, proliferation, motility, toxicity, production of a compound, and cell death. Technological advancements facilitated the development of an array of cell culture types that could be effectively used for analyzing the role of cells in a biological process, their responses to stimuli, physiological changes in a diseased condition, and various other biochemical functions. Cell-based assays are being effectively used to understand the mechanism underlying receptor activation, receptor binding, ligand internalization, sub-cellular localization, and cell signaling. The demand for cell-based assays is largely being fuelled by the drug discovery industry.

Timeline for Analysis
  • Market Estimates and Forecasts for 2016-2024
  • Historic Review 2011-2015

Geographic Markets Analyzed
  • US, Japan, Europe (France, Germany, Italy, UK, Spain and Rest of Europe), and Rest of World

Market Segmentation & Classification
  • Applications:
    • Drug Discovery, ADME Testing, and Basic Research

Major Players
  • BD Biosciences
  • Beckman Coulter, Inc.
  • BioVision, Inc.
  • Cisbio Bioassays
  • Eurofins DiscoverX Corporation
  • Merck KgaA

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