Obesity and diabetes are areas of growing concern across both, developed and developing countries. The rising geriatric population is likely to contribute to an increased prevalence of obesity and diabetes across the global landscape. Biomarker research is likely to facilitate the emergence of novel tools that may be useful for enhanced management of obesity, diabetes and related complications in the near future. There are several biomarkers that are currently being studied for predicting the risk and progression of several diseases such as type 2 diabetes, diabetic kidney disease, obesity and related disorders. Furthermore, companies are looking to leverage new biomarker-based platforms for early diagnosis and timely clinical management of obesity, diabetes and related complications. Biomarker-based research may also open novel paradigms for drug discovery and development obesity and diabetes disorders.