TABLE OF CONTENTS

1 INTRODUCTION 27
1.1 OBJECTIVES OF THE STUDY 27
1.2 MARKET DEFINITION 27
1.2.1 MARKETS COVERED 28
1.2.2 YEARS CONSIDERED FOR THE STUDY 30
1.3 CURRENCY 31
1.4 LIMITATIONS 31
1.5 STAKEHOLDERS 31
2 RESEARCH METHODOLOGY 32
2.1 RESEARCH DATA 32
2.1.1 SECONDARY DATA 34
2.1.1.1 Key data from secondary sources 34
2.1.2 PRIMARY DATA 35
2.1.2.1 Key data from primary sources 36
2.1.2.2 Breakdown of primaries 36
2.2 MARKET SIZE ESTIMATION 37
2.2.1 PRODUCT-BASED MARKET ESTIMATION 38
2.2.2 APPLICATION-BASED MARKET SIZE ESTIMATION 39
2.2.3 PRIMARY RESEARCH VALIDATION 40
2.3 MARKET DATA VALIDATION AND TRIANGULATION 41
2.4 RESEARCH LIMITATIONS & ASSUMPTIONS 42
2.4.1 LIMITATIONS 42
2.5 ASSUMPTIONS FOR THE STUDY 42
3 EXECUTIVE SUMMARY 43
4 PREMIUM INSIGHTS 48
4.1 LIFE SCIENCE INSTRUMENTATION: MARKET OVERVIEW 48
4.2 LIFE SCIENCE INSTRUMENTATION MARKET, BY TECHNOLOGY, 2019 VS 2025 49
4.3 LIFE SCIENCE INSTRUMENTATION MARKET, BY END USER, 2019 VS 2025 50
4.4 GEOGRAPHICAL SNAPSHOT OF THE LIFE SCIENCE INSTRUMENTATION MARKET, 2019 51
5 MARKET OVERVIEW 52
5.1 INTRODUCTION 52
5.2 MARKET DYNAMICS 52
5.2.1 DRIVERS 53
5.2.1.1 Increasing investments in pharmaceutical R&D 53
5.2.1.2 Growing food safety concerns 53
5.2.1.3 Increasing public–private investments in life science research 54
5.2.1.4 Rising incidence of target infectious diseases and genetic disorders 55
5.2.1.5 Advancements in NGS platforms 55
5.2.1.6 Declining costs of genome sequencing 56
5.2.1.7 Growing use of capillary electrophoresis with mass spectroscopy 56
5.2.1.8 Growing adoption of flow cytometry techniques in research and academia 56
5.2.1.9 Rising incidence of hospital-acquired infections 57
5.2.1.10 Increasing outsourcing of sterilization services 58
5.2.2 RESTRAINTS 58
5.2.2.1 High cost of instruments 58
5.2.2.2 Dearth of skilled professionals 59
5.2.2.3 Technical limitations associated with qPCR and dPCR techniques 59
5.2.2.4 High cost of advanced microscopes 59
5.2.3 OPPORTUNITIES 60
5.2.3.1 Growth opportunities in emerging countries 60
5.2.3.1.1 Growing demand for analytical instruments and focus of key market players on emerging countries 60
5.2.3.1.2 Growth of the pharmaceutical and biotechnology industries 61
5.2.3.2 Application of NGS in precision medicine and molecular diagnostics 62
5.2.3.3 Widening application scope of analytical instruments 62
5.2.3.4 Increased demand for personalized medicine 62
5.2.4 CHALLENGES 63
5.2.4.1 Inadequate infrastructure for research in emerging countries 63
5.2.4.2 Ethical issues regarding the privacy of generated data from instrument software 63
5.2.4.3 Pricing pressure faced by prominent players in emerging markets 63
5.3 INDUSTRY TRENDS 63
5.3.1 RISING FOCUS ON NGS INSTRUMENT MINIATURIZATION 63
5.3.2 INCREASING ADOPTION OF HYPHENATED TECHNOLOGIES 64
5.3.3 TIE-UPS BETWEEN ANALYTICAL INSTRUMENT MANUFACTURERS AND RESEARCH LABORATORIES/ACADEMIC INSTITUTIONS 64
5.3.4 MARKET CONSOLIDATION 65
6 LIFE SCIENCE INSTRUMENTATION MARKET, BY TECHNOLOGY 66
6.1 INTRODUCTION 67
6.2 SPECTROSCOPY 68
6.2.1 MASS SPECTROMETERS 69
6.2.1.1 Mass spectrometers are increasingly being used for analytical applications in laboratories 69
6.2.2 MOLECULAR SPECTROMETERS 70
6.2.2.1 Wide application scope of molecular spectrometers to drive the market growth 70

6.2.3 ATOMIC SPECTROMETERS 71
6.2.3.1 Presence of stringent safety regulations has increased use of atomic spectroscopy technologies 71
6.3 CHROMATOGRAPHY 72
6.3.1 LIQUID CHROMATOGRAPHY (LC) SYSTEMS 74
6.3.1.1 Liquid chromatography is the most widely used analytical tool in the pharmaceuticals industry due to its flexibility in separation of many compounds 74
6.3.2 GAS CHROMATOGRAPHY (GC) SYSTEMS 75
6.3.2.1 High requirements for running GC systems are limiting their adoption 75
6.3.3 SUPERCRITICAL FLUID CHROMATOGRAPHY (SFC) SYSTEMS 77
6.3.3.1 SFC system exhibits properties such as low viscosity and high diffusivity and is ideal for use as a mobile phase in chromatography 77
6.3.4 THIN-LAYER CHROMATOGRAPHY (TLC) SYSTEMS 78
6.3.4.1 Ability of TLC to separate several samples concurrently within a relatively short analytical run provides it an edge over other chromatography techniques 78
6.4 PCR 79
6.4.1 QPCR 80
6.4.1.1 Growing adoption of qPCR among researchers and healthcare professionals is expected to boost the growth of qPCR market 80
6.4.2 DPCR 81
6.4.2.1 Ongoing technological developments in the field and significant adoption rate of dPCR products among key end users will impact the market growth 81
6.5 IMMUNOASSAYS 82
6.5.1 HIGH SENSITIVITY AND SPECIFICITY OF IMMUNOASSAY TESTS PROVIDE ACCURATE AND FASTER RESULTS 82
6.6 LYOPHILIZATION 84
6.6.1 TRAY-STYLE FREEZE DRYERS 85
6.6.1.1 Increasing use of contract manufacturing & contract lyophilization services in the pharmaceutical industry and growing commercialization of labile drugs 85
6.6.2 MANIFOLD FREEZE DRYERS 86
6.6.2.1 Increase in government funding for academic research and surge in research activities in the field of lyophilization 86
6.6.3 SHELL (ROTARY) FREEZE DRYERS 87
6.6.3.1 Increasing research for the development of food ingredients and biologic molecules is expected to boost their demand 87
6.7 LIQUID HANDLING 88
6.7.1 ELECTRONIC HANDLING SYSTEMS MARKET 90
6.7.1.1 High accuracy and reproducibility of electronic handling systems promote its use in the pharmaceutical and biotechnology industries 90
6.7.2 AUTOMATED HANDLING SYSTEMS MARKET 90
6.7.2.1 High cost of automated handling systems and time-consuming set-up may hinder the adoption of these systems 90

6.7.3 MANUAL HANDLING SYSTEMS MARKET 91
6.7.3.1 These devices are mostly used to manually dispense a selected quantity of reagents, samples, or other liquids to a designated container 91
6.8 CLINICAL CHEMISTRY ANALYZERS 92
6.8.1 LARGE OPERATIONAL CYCLES OF THE DEVICE MAY REDUCE DEMAND AS FREQUENT PURCHASES ARE NOT POSSIBLE 92
6.9 MICROSCOPY 94
6.9.1 OPTICAL MICROSCOPES MARKET 96
6.9.1.1 Low costs, ease of use, and low maintenance costs are the major factors driving the growth of the segment 96
6.9.2 ELECTRON MICROSCOPES MARKET 97
6.9.2.1 Increasing R&D and easy availability of funds to support adoption of electron microscopes 97
6.9.3 SCANNING PROBE MICROSCOPY MARKET 98
6.9.3.1 High growth in the atomic force microscopes segment to aid market growth for scanning probe microscopy 98
6.9.4 OTHER MICROSCOPES MARKET 99
6.10 FLOW CYTOMETRY 100
6.10.1 CELL ANALYZERS MARKET 101
6.10.1.1 Technological advancements in cell analyzers resulting in new product launches 101
6.10.2 CELL SORTERS 102
6.10.2.1 The development cost effective cell sorters can enhance its use outside of the core laboratories 102
6.11 NEXT-GENERATION SEQUENCING (NGS) 103
6.11.1 THE INCREASING AVAILABILITY OF CHEAPER SEQUENCING PLATFORMS WILL DRIVE THE MARKET GROWTH 103
6.12 CENTRIFUGES 105
6.12.1 MICROCENTRIFUGES MARKET 106
6.12.1.1 Increasing prevalence of diseases such as diabetes has increased the use of microcentrifuges 106
6.12.2 MULTIPURPOSE CENTRIFUGES MARKET 107
6.12.2.1 Increasing research on cell cultures due to the growing prevalence of diseases will fuel the growth of the market 107
6.12.3 MINICENTRIFUGES MARKET 108
6.12.3.1 Small size and smooth operation are factors increasing their adoption 108
6.12.4 ULTRACENTRIFUGES MARKET 109
6.12.4.1 Risks associated with the use of ultracentrifuges may hamper the growth in the segment 109
6.13 ELECTROPHORESIS 109
6.13.1 GEL ELECTROPHORESIS SYSTEMS MARKET 111
6.13.1.1 Increasing demand for gel electrophoresis in proteomics research and personalized medicine to fuel the growth of the segment 111
6.13.2 CAPILLARY ELECTROPHORESIS (CE) SYSTEMS MARKET 112
6.13.2.1 Numerous analytical benefits offered by CE systems is the key factor driving the market growth 112
6.14 CELL COUNTING 113
6.14.1 AUTOMATED CELL COUNTERS MARKET 115
6.14.1.1 Growing focus on research related to life-threatening diseases is expected to be the major growth driver 115
6.14.2 HEMOCYTOMETERS AND MANUAL CELL COUNTERS MARKET 116
6.14.2.1 Manual cell counters are rapidly being replaced by advanced automated cell counting instruments 116
6.15 OTHER TECHNOLOGIES 117
6.15.1 LABORATORY FREEZERS 120
6.15.1.1 Freezers 121
6.15.1.2 Refrigerators 121
6.15.1.2.1 Blood bank refrigerators 121
6.15.1.2.2 Chromatography refrigerators 121
6.15.1.2.3 Explosion-proof refrigerators 121
6.15.1.2.4 Flammable material refrigerators 122
6.15.1.2.5 Laboratory refrigerators 122
6.15.1.2.6 Pharmacy refrigerators 122
6.15.1.3 Cryopreservation systems 122
6.15.2 HEAT STERILIZATION 123
6.15.2.1 Moist heat/steam sterilization Instruments 124
6.15.2.2 Dry heat sterilization instrumentation 125
6.15.3 MICROPLATE SYSTEMS 126
6.15.3.1 Microplate readers 127
6.15.3.2 Microplate dispensers 127
6.15.3.3 Microplate washers 128
6.15.4 LABORATORY BALANCES 128
6.15.5 COLORIMETERS 128
6.15.6 INCUBATORS 129
6.15.7 FUME HOODS 130
6.15.8 ROBOTIC SYSTEMS 131
6.15.8.1 Robotic arms 132
6.15.8.2 Track robot systems 132
6.15.9 PH METERS 132
6.15.10 CONDUCTIVITY AND RESISTIVITY METERS 133
6.15.11 DISSOLVED CO2 AND O2 METERS 134
6.15.12 TITRATORS 135
6.15.13 GAS ANALYZERS 135
6.15.14 TOC ANALYZERS 136
6.15.15 THERMAL ANALYZERS 137
6.15.16 SHAKERS/ROTATORS AND STIRRERS 138
7 LIFE SCIENCE INSTRUMENTATION MARKET, BY APPLICATION 139
7.1 INTRODUCTION 140
7.2 RESEARCH APPLICATIONS 140
7.2.1 INCREASING RESEARCH ON GENOMICS AND FOR DRUG DEVELOPMENT IS EXPECTED TO DRIVE THE MARKET GROWTH 140
7.3 CLINICAL & DIAGNOSTIC APPLICATIONS 142
7.3.1 INCREASING PREVALENCE OF INFECTIOUS DISEASES ACROSS THE GLOBE WILL LEAD TO INCREASE IN THE NUMBER OF DIAGNOSTIC TESTS PERFORMED 142
7.4 OTHER APPLICATIONS 143
7.4.1 HIGH ACCURACY AND EFFICIENCY HAVE INCREASED THE USE OF ANALYTICAL TECHNOLOGIES IN SEVERAL INDUSTRIES/SECTORS 143
8 LIFE SCIENCE INSTRUMENTATION MARKET, BY END USER 145
8.1 INTRODUCTION 146
8.2 HOSPITALS AND DIAGNOSTIC LABORATORIES 146
8.2.1 GROWING ADOPTION OF MOLECULAR DIAGNOSTICS IS ONE OF THE IMPORTANT FACTORS RESPONSIBLE FOR INCREASING USE OF LIFE SCIENCE TECHNOLOGIES IN HOSPITALS AND DIAGNOSTIC LABS 146
8.3 PHARMACEUTICAL AND BIOTECHNOLOGY COMPANIES 147
8.3.1 INCREASING FOCUS OF PHARMA & BIOTECH COMPANIES ON EXTENDING THEIR PRODUCT PIPELINE WILL BOOST THE MARKET GROWTH 147
8.4 ACADEMIC AND RESEARCH INSTITUTES 148
8.4.1 EMPHASIS ON PRACTICAL APPLICATIONS RATHER THAN THEORETICAL KNOWLEDGE HAS INCREASED THE USE OF HIGH-END INSTRUMENTS IN ACADEMIC INSTITUTIONS 148
8.5 AGRICULTURE & FOOD INDUSTRIES 149
8.5.1 ANALYSIS OF FOOD PRODUCTS FOR MAINTAINING QUALITY & SAFETY, DEFINING STANDARDS, AND AUTHENTICITY WILL INCREASE THE ADOPTION OF LIFE SCIENCE INSTRUMENTS 149
8.6 ENVIRONMENTAL TESTING LABS 150
8.6.1 CONCERNS REGARDING ENVIRONMENTAL POLLUTION AND IMPOSITION OF REGULATIONS BY GOVERNMENT BODIES WILL INCREASE ADOPTION OF ANALYTICAL TOOLS IN THIS SEGMENT 150
8.7 CLINICAL RESEARCH ORGANIZATIONS 151
8.7.1 INCREASING FUNDING FOR R&D TO CROS WILL FUEL MARKET GROWTH 151
8.8 OTHER END USERS 152
8.8.1 LABORATORY AUTOMATION & TECHNOLOGICAL INTEGRATION BY VARIOUS END USERS WILL DRIVE THE MARKET GROWTH 152

9 LIFE SCIENCE INSTRUMENTATION MARKET, BY REGION 154
9.1 INTRODUCTION 155
9.2 NORTH AMERICA 155
9.2.1 US 162
9.2.1.1 Large presence of major pharmaceutical and biotechnology companies in the country will be key factor for country-level market growth 162
9.2.2 CANADA 164
9.2.2.1 Increasing funding for genomic and clinical research is expected to increase adoption of life science instrumentation technologies in the country 164
9.3 EUROPE 166
9.3.1 GERMANY 172
9.3.1.1 Favorable reimbursement and insurance scenario in the country for various diagnostic tests is supporting the market growth 172
9.3.2 UK 174
9.3.2.1 Rising number of research activities and academia–industry partnerships will drive growth of the UK market 174
9.3.3 FRANCE 175
9.3.3.1 Increasing investments in infrastructure development pertaining to life science R&D is expected to increase the adoption of new life science instrumentation technologies in the country 175
9.3.4 SPAIN 177
9.3.4.1 Growing focus on cancer research and advanced R&D structure will support the growth of the country-level market 177
9.3.5 ITALY 178
9.3.5.1 Advancements in biotechnology and increasing R&D investments by pharmaceutical companies are expected to fuel the demand for mass spectrometry instruments in Italy 178
9.3.6 REST OF EUROPE (ROE) 180
9.3.6.1 Increasing demand for life science instrumentation technologies in the Eastern European region is expected to fuel the market growth 180
9.4 ASIA PACIFIC 181
9.4.1 JAPAN 188
9.4.1.1 Growing adoption of technologically advanced products will increase adoption of life science instruments 188
9.4.2 CHINA 190
9.4.2.1 Increasing production and export of pharmaceuticals will favor the growth of the market for life science instruments 190
9.4.3 INDIA 191
9.4.3.1 Increasing healthcare expenditure in the country is expected to drive the market 191
9.4.4 AUSTRALIA 193
9.4.4.1 Personalized medical care, cancer diagnostics, and agricultural research are driving the growth of the country-level market 193
9.4.5 SOUTH KOREA 195
9.4.5.1 Growing awareness as well as broad applications of life science technologies in the country are expected to boost market growth 195
9.4.6 REST OF ASIA PACIFIC (ROAPAC) 196
9.4.6.1 Growing healthcare spending, developing healthcare infrastructure, and growing middle-class population in these countries will increase adoption of life science instrumentation 196
9.5 LATIN AMERICA 198
9.5.1 BRAZIL 204
9.5.1.1 Increasing research activities and minimal trade barriers for laboratory equipment and medical devices is expected to drive the market 204
9.5.2 MEXICO 206
9.5.2.1 Presence of favorable business environment for market players is expected to attract investment from major market players in the country 206
9.5.3 REST OF LATIN AMERICA (ROLA) 207
9.5.3.1 Focus of market players on regional expansion, government initiatives to increase R&D, and rising incidence of cancer and HIV/AIDS in the region will boost the market 207
9.6 MIDDLE EAST & AFRICA 208
10 COMPETITIVE LANDSCAPE 216
10.1 OVERVIEW 216
10.2 MARKET RANK ANALYSIS, 2018 218
10.3 COMPETITIVE SCENARIO 219
10.3.1 PRODUCT LAUNCHES AND APPROVALS 219
10.3.2 ACQUISITIONS 219
10.3.3 PARTNERSHIPS, COLLABORATIONS, AND AGREEMENTS 220
10.4 COMPETITIVE LEADERSHIP MAPPING (OVERALL MARKET) 221
10.5 COMPETITIVE LEADERSHIP MAPPING: MAJOR MARKET PLAYERS (2018) 221
10.5.1 VISIONARY LEADERS 221
10.5.2 INNOVATORS 221
10.5.3 DYNAMIC DIFFERENTIATORS 221
10.5.4 EMERGING COMPANIES 222

11 COMPANY PROFILES 223
(Business Overview, Products Offered, Recent Developments, MnM View)*
11.1 AGILENT TECHNOLOGIES, INC. 223
11.2 BECTON, DICKINSON AND COMPANY 231
11.3 BIO-RAD LABORATORIES, INC. 234
11.4 BRUKER CORPORATION 238
11.5 DANAHER CORPORATION 241
11.6 EPPENDORF AG 247
11.7 GE HEALTHCARE 250
11.8 HITACHI HIGH-TECHNOLOGIES CORPORATION 253
11.9 HORIBA LTD. 258
11.10 MERCK KGAA 262
11.11 PERKINELMER, INC. 265
11.12 QIAGEN N.V. 271
11.13 SHIMADZU CORPORATION 273
11.14 THERMO FISHER SCIENTIFIC, INC. 279
11.15 WATERS CORPORATION 288
11.16 OTHER COMPANIES 292
11.16.1 BIOMERIEUX S.A. 292
11.16.2 CARL ZEISS AG 293
11.16.3 JEOL LTD. 294
11.16.4 TECAN GROUP LTD. 295
11.16.5 SIGMA LABORZENTRIFUGEN GMBH 295
*Business Overview, Products Offered, Recent Developments, MnM View might not be captured in case of unlisted companies.
12 APPENDIX 296
12.1 DISCUSSION GUIDE 296
12.2 KNOWLEDGE STORE: MARKETSANDMARKETS’ SUBSCRIPTION PORTAL 302
12.3 AVAILABLE CUSTOMIZATIONS 304
12.4 RELATED REPORTS 304
12.5 AUTHOR DETAILS 306