1.1 List of Tables 4
1.2 List of Figures 7

2 Introduction 8
2.1 Transcatheter Mitral Valve Implantation (TMVI) Overview 8

3 Products under Development 9
3.1 Transcatheter Mitral Valve Implantation (TMVI) - Pipeline Products by Stage of Development 9
3.2 Transcatheter Mitral Valve Implantation (TMVI) - Pipeline Products by Territory 10
3.3 Transcatheter Mitral Valve Implantation (TMVI) - Pipeline Products by Regulatory Path 11
3.4 Transcatheter Mitral Valve Implantation (TMVI) - Pipeline Products by Estimated Approval Date 12
3.5 Transcatheter Mitral Valve Implantation (TMVI) - Ongoing Clinical Trials 13

4 Transcatheter Mitral Valve Implantation (TMVI) - Pipeline Products under Development by Companies 14
4.1 Transcatheter Mitral Valve Implantation (TMVI) Companies - Pipeline Products by Stage of Development 14
4.2 Transcatheter Mitral Valve Implantation (TMVI) - Pipeline Products by Stage of Development 15

5 Transcatheter Mitral Valve Implantation (TMVI) Companies and Product Overview 17
5.1 4C Medical Technologies Inc Company Overview 17
5.1.1 4C Medical Technologies Inc Pipeline Products & Ongoing Clinical Trials Overview 17
5.2 Annulon Company Overview 20
5.2.1 Annulon Pipeline Products & Ongoing Clinical Trials Overview 20
5.3 CardioMech AS Company Overview 21
5.3.1 CardioMech AS Pipeline Products & Ongoing Clinical Trials Overview 21
5.4 Cardiovalve Ltd Company Overview 22
5.4.1 Cardiovalve Ltd Pipeline Products & Ongoing Clinical Trials Overview 22
5.5 Cephea Valve Technologies, Inc. Company Overview 26
5.5.1 Cephea Valve Technologies, Inc. Pipeline Products & Ongoing Clinical Trials Overview 26
5.6 Colibri Heart Valve LLC Company Overview 29
5.6.1 Colibri Heart Valve LLC Pipeline Products & Ongoing Clinical Trials Overview 29
5.7 Daidalos Solutions BV Company Overview 30
5.7.1 Daidalos Solutions BV Pipeline Products & Ongoing Clinical Trials Overview 30
5.8 Direct Flow Medical Inc (Ictive) Company Overview 31
5.8.1 Direct Flow Medical Inc (Ictive) Pipeline Products & Ongoing Clinical Trials Overview 31
5.9 Dura LLC Company Overview 32
5.9.1 Dura LLC Pipeline Products & Ongoing Clinical Trials Overview 32
5.10 Edwards Lifesciences Corp Company Overview 33
5.10.1 Edwards Lifesciences Corp Pipeline Products & Ongoing Clinical Trials Overview 33
5.11 Emory University Company Overview 46
5.11.1 Emory University Pipeline Products & Ongoing Clinical Trials Overview 46
5.12 Foldax Inc Company Overview 47
5.12.1 Foldax Inc Pipeline Products & Ongoing Clinical Trials Overview 47
5.13 HighLife SAS Company Overview 48
5.13.1 HighLife SAS Pipeline Products & Ongoing Clinical Trials Overview 48
5.14 LivaNova PLC Company Overview 51
5.14.1 LivaNova PLC Pipeline Products & Ongoing Clinical Trials Overview 51
5.15 Medtronic plc Company Overview 55
5.15.1 Medtronic plc Pipeline Products & Ongoing Clinical Trials Overview 55
5.16 Micro Interventiol Devices, Inc. Company Overview 60
5.16.1 Micro Interventiol Devices, Inc. Pipeline Products & Ongoing Clinical Trials Overview 60
5.17 MitrAssist Ltd. Company Overview 61
5.17.1 MitrAssist Ltd. Pipeline Products & Ongoing Clinical Trials Overview 61
5.18 MValve Technologies Ltd. Company Overview 62
5.18.1 MValve Technologies Ltd. Pipeline Products & Ongoing Clinical Trials Overview 62
5.19 viGate Cardiac Structures, Inc. Company Overview 65
5.19.1 viGate Cardiac Structures, Inc. Pipeline Products & Ongoing Clinical Trials Overview 65
5.20 Neovasc Inc Company Overview 68
5.20.1 Neovasc Inc Pipeline Products & Ongoing Clinical Trials Overview 68
5.21 Polares Medical SA Company Overview 72
5.21.1 Polares Medical SA Pipeline Products & Ongoing Clinical Trials Overview 72
5.22 Sino Medical Sciences Technology Inc Company Overview 73
5.22.1 Sino Medical Sciences Technology Inc Pipeline Products & Ongoing Clinical Trials Overview 73
5.23 Trinity College Dublin Company Overview 74
5.23.1 Trinity College Dublin Pipeline Products & Ongoing Clinical Trials Overview 74
5.24 University College London Company Overview 75
5.24.1 University College London Pipeline Products & Ongoing Clinical Trials Overview 75
5.25 Venus MedTech Company Overview 76
5.25.1 Venus MedTech Pipeline Products & Ongoing Clinical Trials Overview 76

6 Transcatheter Mitral Valve Implantation (TMVI)- Recent Developments 77
6.1 Nov 21, 2019: LivaNova to revamp heart valve division to affect 150 jobs 77
6.2 Nov 19, 2019: Medtronic reports second quarter fincial results for the year 2019 77
6.3 Oct 23, 2019: Edwards Lifesciences reports third quarter results 80
6.4 Oct 21, 2019: Sean Salmon med executive vice president and group president of Medtronic Diabetes 83
6.5 Oct 15, 2019: Neovasc announces Notice of US Patent Granted for TiaraTranscatheter Device for treatment of severe mitral regurgitation 84
6.6 Oct 10, 2019: CINDE announces Edwards Lifesciences invests $100 million to expand its operations in Costa Rica 84
6.7 Sep 30, 2019: AltaValve, 4C Medical’s Novel Transcatheter Mitral Regurgitation Device Highlighted at TCT 2019 86
6.8 Sep 27, 2019: Medtronic announces early feasibility Trial for Intrepid Transcatheter Mitral Valve Replacement System with Transfemoral Transseptal approach 86
6.9 Aug 28, 2019: Medtronic announces planned leadership succession 87
6.10 Aug 20, 2019: Medtronic reports first quarter fincial results for 2019 89
6.11 Jul 24, 2019: Former Medtronic Executive Sean Ginney med VP of Sales at Current Health 91
6.12 Jul 23, 2019: Edwards Lifesciences reports second quarter results for the year 2019 92
6.13 Jun 17, 2019: Tiara featured in presentation at 11th Annual TVT 2019 English 94
6.14 May 23, 2019: Medtronic announces fiscal year and fourth quarter 2019 fincial results 94
6.15 May 22, 2019: Edwards announces milestones for Transcatheter Mitral Program 97
6.16 May 20, 2019: Novel technique reduces obstruction risk in heart valve replacement 98
6.17 Apr 23, 2019: Edwards Lifesciences announces first quarter results 99
6.18 Apr 17, 2019: Neovasc announces resolution of last remaining active litigation 100
6.19 Mar 25, 2019: Medtronic launches Medtech Innovation Accelerator in Shanghai 101
6.20 Mar 21, 2019: Neovasc wins German court appeal; announces german court’s Decision to dismiss CardiAQ’s claim to co-inventorship of a European patent for Tiara 102
6.21 Mar 04, 2019: Neovasc’s Tiara Mitral Valve replacement technology featured in update presentation at the CRT 2019 Meeting 103
6.22 Feb 25, 2019: 4C Medical’s novel mitral regurgitation therapy to be highlighted at CRT 2019 Meeting 104
6.23 Feb 21, 2019: Edwards Lifesciences secures CE-Mark for Pascal system 104
6.24 Feb 21, 2019: Neovasc celebrates 5-year anniversary of Tiara patient as the longest surviving transcatheter mitral valve replacement in the world 105
6.25 Feb 20, 2019: Micro Interventiol Devices reaches settlement agreement with Neovasc 106
6.26 Jan 31, 2019: Edwards Lifesciences reports fincial results for the quarter ended December 31, 2018 106
6.27 Jan 29, 2019: Neovasc receives approval to proceed with phase 2 of TIARA-II study from clinical regulators in Germany and the UK 108
6.28 Jan 22, 2019: Neovasc Announces Dismissal of Claim brought by Edwards Lifesciences 109
6.29 Jan 15, 2019: Boston Scientific, Edwards Lifesciences agree to global litigation settlement 109
6.30 Jan 09, 2019: Medtronic Foundation Recognizes 12 Bakken Invitation Honorees for Driving Positive Change in Healthcare 109
7 Appendix 111
7.1 Methodology 111
7.2 About GlobalData 114
7.3 Contact Us 114
7.4 Disclaimer 114