Table of Contents 2
List of Tables 7
List of Figures 7
Lead Discovery Center GmbH Spshot 8
Lead Discovery Center GmbH Overview 8
Key Information 8
Key Facts 8
Lead Discovery Center GmbH - Research and Development Overview 9
Key Therapeutic Areas 9
Lead Discovery Center GmbH - Pipeline Review 13
Pipeline Products by Stage of Development 13
Pipeline Products - Monotherapy 14
Pipeline Products - Partnered Products 15
Partnered Products/Combition Treatment Modalities 16
Pipeline Products - Out-Licensed Products 17
Out-Licensed Products/Combition Treatment Modalities 18
Lead Discovery Center GmbH - Pipeline Products Glance 19
Lead Discovery Center GmbH - Early Stage Pipeline Products 19
Preclinical Products/Combition Treatment Modalities 19
Discovery Products/Combition Treatment Modalities 20
Lead Discovery Center GmbH - Drug Profiles 22
Small Molecule for Target RhoGEF12 for Cardiovascular Disease 22
Product Description 22
Mechanism of Action 22
R&D Progress 22
Small Molecule to Activate Beclin1 for Neurodegenerative Diseases and Viral Infections 23
Product Description 23
Mechanism of Action 23
R&D Progress 23
Small Molecule to Inhibit FKBP51 for Anxiety and Major Depressive Disorder 24
Product Description 24
Mechanism of Action 24
R&D Progress 24
Small Molecules to Antagonize RON Kise for Oncology 25
Product Description 25
Mechanism of Action 25
R&D Progress 25
Small Molecules to Inhibit Cyclophilin for Immunology and Respiratory Disorders 26
Product Description 26
Mechanism of Action 26
R&D Progress 26
englerin A 27
Product Description 27
Mechanism of Action 27
R&D Progress 27
Small Molecule 1 for Oncology 28
Product Description 28
Mechanism of Action 28
R&D Progress 28
Small Molecule 2 for Oncology 29
Product Description 29
Mechanism of Action 29
R&D Progress 29
Small Molecule 3 for Oncology 30
Product Description 30
Mechanism of Action 30
R&D Progress 30
Small Molecule 4 for Oncology 31
Product Description 31
Mechanism of Action 31
R&D Progress 31
Small Molecule for AMD, Inflammation and Oncology 32
Product Description 32
Mechanism of Action 32
R&D Progress 32
Small Molecule for Amyotrophic Lateral Sclerosis 33
Product Description 33
Mechanism of Action 33
R&D Progress 33
Small Molecule for Chlamydia Infections 34
Product Description 34
Mechanism of Action 34
R&D Progress 34
Small molecule for Multiple Sclerosis 35
Product Description 35
Mechanism of Action 35
R&D Progress 35
Small Molecule for Oncology 36
Product Description 36
Mechanism of Action 36
R&D Progress 36
Small Molecule to Activate TRIM32 for Neurodegenerative Diseases 37
Product Description 37
Mechanism of Action 37
R&D Progress 37
Small Molecule to Agonize P2Y6R for Type 2 Diabetes 38
Product Description 38
Mechanism of Action 38
R&D Progress 38
Small Molecule to Block TRPC4 and TRPC5 for Cardiovascular Disease and Epilepsy 39
Product Description 39
Mechanism of Action 39
R&D Progress 39
Small Molecule to Inhibit AML1/ETO for Acute Myeloid Leukemia 40
Product Description 40
Mechanism of Action 40
R&D Progress 40
Small Molecule to Inhibit CDK12 and CDK13 for Oncology 41
Product Description 41
Mechanism of Action 41
R&D Progress 41
Small Molecule to Inhibit Chemerin for Inflammation 42
Product Description 42
Mechanism of Action 42
R&D Progress 42
Small Molecule to Inhibit degS Serine Endoprotease for Bacterial Infections 43
Product Description 43
Mechanism of Action 43
R&D Progress 43
Small Molecule to Inhibit GLUT1 for Oncology 44
Product Description 44
Mechanism of Action 44
R&D Progress 44
Small Molecule to Inhibit GRK5 for Type 2 Diabetes 45
Product Description 45
Mechanism of Action 45
R&D Progress 45
Small Molecule to Inhibit MARK2 for Alzheimer’s Disease 46
Product Description 46
Mechanism of Action 46
R&D Progress 46
Small Molecule to Inhibit Plexin-B1/Sema4D for Multiple Sclerosis and Osteoporosis 47
Product Description 47
Mechanism of Action 47
R&D Progress 47
Small Molecule to Inhibit RabGGTase for Solid Tumors 48
Product Description 48
Mechanism of Action 48
R&D Progress 48
Small Molecule to Inhibit SFRP1 for Oncology 49
Product Description 49
Mechanism of Action 49
R&D Progress 49
Small Molecule to Inhibit Steroid Sulfatase for Oncology 50
Product Description 50
Mechanism of Action 50
R&D Progress 50
Small Molecule to Target Draxin for Oncology 51
Product Description 51
Mechanism of Action 51
R&D Progress 51
Small Molecule to Target Hedgehog Pathway for Oncology 52
Product Description 52
Mechanism of Action 52
R&D Progress 52
Small Molecule to Target K-Ras/PDE Delta for Oncology 53
Product Description 53
Mechanism of Action 53
R&D Progress 53
Small Molecule to Target Nrg1-ErbB4 Pathway for Schizophrenia and Cardiovascular Diseases 54
Product Description 54
Mechanism of Action 54
R&D Progress 54
Small Molecule to Target SLC6A15 for Major Depressive Disorder 55
Product Description 55
Mechanism of Action 55
R&D Progress 55
Small Molecules 1 for Oncology 56
Product Description 56
Mechanism of Action 56
R&D Progress 56
Small Molecules for Charcot-Marie-Tooth Disease Type I A 57
Product Description 57
Mechanism of Action 57
R&D Progress 57
Small Molecules for Influenza 58
Product Description 58
Mechanism of Action 58
R&D Progress 58
Small Molecules for Lung Cancer 59
Product Description 59
Mechanism of Action 59
R&D Progress 59
Small Molecules for Oncology 60
Product Description 60
Mechanism of Action 60
R&D Progress 60
Small Molecules to Activate GFAT for Alzheimer’s Disease 61
Product Description 61
Mechanism of Action 61
R&D Progress 61
Small Molecules to Agonize GPR81 for Atherosclerosis and Obesity 62
Product Description 62
Mechanism of Action 62
R&D Progress 62
Small Molecules to Inhibit LRRK2 for Parkinson’s Disease 63
Product Description 63
Mechanism of Action 63
R&D Progress 63
Small Molecules to Inhibit NET Formation for Sepsis and SLE 64
Product Description 64
Mechanism of Action 64
R&D Progress 64
Small Molecules to Target Notch Sigling Pathway for Oncology 65
Product Description 65
Mechanism of Action 65
R&D Progress 65
Small Molecules to Target SIRT7 for Cardiovacular Diseases, Metabolic Syndrome and Oncology 66
Product Description 66
Mechanism of Action 66
R&D Progress 66
Lead Discovery Center GmbH - Pipeline Alysis 67
Lead Discovery Center GmbH - Pipeline Products by Target 67
Lead Discovery Center GmbH - Pipeline Products by Molecule Type 69
Lead Discovery Center GmbH - Pipeline Products by Mechanism of Action 70
Lead Discovery Center GmbH - Recent Pipeline Updates 72
Lead Discovery Center GmbH - Dormant Projects 73
Lead Discovery Center GmbH - Locations And Subsidiaries 74
Head Office 74
Appendix 75
Methodology 75
Coverage 75
Secondary Research 75
Primary Research 75
Expert Panel Validation 75
Contact Us 75
Disclaimer 76